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keywords Adverse Drug Reactions
keywords Developmental Pharmacogenomics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Dr. Leeder’s research focuses on characterizing the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

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Concept Abnormalities, Drug-Induced
Concept Acetaminophen
Concept Acetylcysteine
Concept Acetyltransferases
Concept Acute-Phase Proteins
Concept Adenosine Triphosphate
Concept Adrenal Cortex Hormones
Concept Adrenergic beta-Antagonists
Concept Alcohol Dehydrogenase
Concept Ethanol
Concept Aldehyde Dehydrogenase
Concept Aminoimidazole Carboxamide
Concept Central Nervous System Stimulants
Concept Analgesics
Concept Analgesics, Opioid
Concept Androgens
Concept Androstadienes
Concept Aniline Compounds
Concept Antibodies, Anti-Idiotypic
Concept Anti-Infective Agents
Concept Anti-Infective Agents, Local
Concept Anti-Infective Agents, Urinary
Concept Anti-Inflammatory Agents
Concept Anti-Ulcer Agents
Concept Anti-Bacterial Agents
Concept Antibiotics, Antineoplastic
Concept Antibodies
Concept Antibodies, Monoclonal
Concept Anticoagulants
Concept Anticonvulsants
Concept Antidepressive Agents
Concept Antiemetics
Concept Antifungal Agents
Concept Epitopes
Concept Antigens
Concept Antimetabolites
Concept Antimetabolites, Antineoplastic
Concept Antineoplastic Agents
Concept Antioxidants
Concept Antitussive Agents
Concept Aryl Hydrocarbon Hydroxylases
Concept Arylamine N-Acetyltransferase
Concept Autoantibodies
Concept Autoantigens
Concept Baclofen
Concept Base Sequence
Concept Beclomethasone
Concept Benzhydryl Compounds
Concept Benzodiazepines
Concept Binding Sites
Concept Binding Sites, Antibody
Concept Bronchodilator Agents
Concept Buserelin
Concept Caffeine
Concept Calcium
Concept Carbamazepine
Concept Carbon Dioxide
Concept Carbon Isotopes
Concept Carboxylic Acids
Concept Carboxylic Ester Hydrolases
Concept Carrier Proteins
Concept Catechol O-Methyltransferase
Concept Ceftazidime
Concept Cephalosporins
Concept Child Development
Concept Ciprofloxacin
Concept Cisplatin
Concept Clotrimazole
Concept Clozapine
Concept Codeine
Concept Contraceptive Agents
Concept Contraceptives, Oral
Concept Cotinine
Concept Cytochrome P-450 Enzyme System
Concept Cytosine
Concept Debrisoquin
Concept Deferoxamine
Concept Dehydroepiandrosterone
Concept Delayed-Action Preparations
Concept Drug Eruptions
Concept Deuterium
Concept Dexamethasone
Concept Dextromethorphan
Concept Dextrorphan
Concept Dibenzazepines
Concept Dicyclomine
Concept Digoxin
Concept Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Concept Disulfides
Concept Dithionitrobenzoic Acid
Concept DNA
Concept DNA, Fungal
Concept DNA, Viral
Concept Dosage Forms
Concept Dose-Response Relationship, Drug
Concept Doxylamine
Concept Drug Administration Routes
Concept Drug Administration Schedule
Concept Drug Combinations
Concept Drug Evaluation
Concept Drug Hypersensitivity
Concept Drug Industry
Concept Drug Interactions
Concept Drug Labeling
Concept Drug Evaluation, Preclinical
Concept Drug Therapy
Concept Drug Therapy, Combination
Concept Pharmaceutical Preparations
Concept Nonprescription Drugs
Concept Environmental Pollutants
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Concept Enzymes
Concept Epoxide Hydrolases
Concept Erythromycin
Concept Esterases
Concept Ethanolamines
Concept Ethinyl Estradiol
Concept Exons
Concept Expectorants
Concept Factor V
Concept Fatty Acids, Unsaturated
Concept Ferredoxin-NADP Reductase
Concept Embryonic and Fetal Development
Concept Fluoresceins
Concept Fluorescent Dyes
Concept Fluoxetine
Concept Folic Acid
Concept Folic Acid Antagonists
Concept Gentamicins
Concept Glucagon
Concept Glucose
Concept Glucuronates
Concept Glutathione
Concept Glutathione Reductase
Concept Glutathione Transferase
Concept Haptens
Concept Heat-Shock Proteins
Concept Histamine
Concept Histamine Antagonists
Concept HLA Antigens
Concept Mixed Function Oxygenases
Concept Hypnotics and Sedatives
Concept Hypochlorous Acid
Concept Immunoglobulin G
Concept Imines
Concept Immune Sera
Concept Immunosuppressive Agents
Concept Indoles
Concept Indomethacin
Concept Introns
Concept Ionophores
Concept Ions
Concept Iron
Concept Isoenzymes
Concept Isoflavones
Concept Isomerases
Concept Ketoconazole
Concept Peptidyl-Dipeptidase A
Concept Lactones
Concept Legislation, Drug
Concept Lidocaine
Concept Cholesterol, LDL
Concept Luciferases
Concept Membrane Glycoproteins
Concept Methionine Sulfoximine
Concept Methotrexate
Concept Methylamines
Concept Methyltransferases
Concept Metoprolol
Concept Metronidazole
Concept Microfilament Proteins
Concept Midazolam
Concept Mitogens
Concept Morphine
Concept Morpholines
Concept Muscle Relaxants, Central
Concept Peroxidase
Concept NAD
Concept NADP
Concept NADPH-Ferrihemoprotein Reductase
Concept Naltrexone
Concept Naphthalenes
Concept Narcotic Antagonists
Concept Neoplasm Proteins
Concept Nicotine
Concept Nitriles
Concept Nitrobenzoates
Concept Norgestrel
Concept Omeprazole
Concept Oxidoreductases
Concept Oxidoreductases, N-Demethylating
Concept Oximes
Concept Oxycodone
Concept Oxygenases
Concept Peptide Fragments
Concept Phenethylamines
Concept Phenobarbital
Concept Phenols
Concept Phenytoin
Concept Phosphodiesterase Inhibitors
Concept Pimozide
Concept Pirenzepine
Concept Plasmids
Concept Polyglutamic Acid
Concept Prilocaine
Concept Promoter Regions, Genetic
Concept Propylamines
Concept Protein-Tyrosine Kinases
Concept Proteins
Concept Proto-Oncogene Proteins
Concept Pteroylpolyglutamic Acids
Concept Pulmonary Surfactants
Concept Pyridines
Concept Pyridoxine
Concept Quinidine
Concept Receptors, Steroid
Concept Receptors, Virus
Concept Recombinant Proteins
Concept Ribonucleotides
Concept RNA
Concept RNA, Messenger
Concept Stereoisomerism
Concept Steroid Hydroxylases
Concept Sulfamethoxazole
Concept Sulfates
Concept Sulfonamides
Concept Teratogens
Concept Testosterone
Concept Tetrahydrofolates
Concept Tetrazolium Salts
Concept Theophylline
Concept Thiazoles
Concept Thromboxane-A Synthase
Concept Tobramycin
Concept Tramadol
Concept Antipsychotic Agents
Concept Anti-Anxiety Agents
Concept Transcription Factors
Concept Transferases
Concept Triglycerides
Concept Trimethoprim
Concept Biomarkers, Tumor
Concept Glucuronosyltransferase
Concept United States Food and Drug Administration
Concept Valproic Acid
Concept Nasal Decongestants
Concept Vitamin D
Concept Vitamin K
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Concept Warfarin
Concept Xanthenes
Concept Xanthine Oxidase
Concept Drug Design
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Concept Sulfotransferases
Concept Arylsulfotransferase
Concept Xenobiotics
Concept Citalopram
Concept Drugs, Investigational
Concept Trimethoprim, Sulfamethoxazole Drug Combination
Concept Gene Library
Concept Mifepristone
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Concept Cytokines
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Concept Drug Delivery Systems
Concept Drug Costs
Concept Tacrolimus
Concept Bupropion
Concept NAD(P)H Dehydrogenase (Quinone)
Concept Fluvoxamine
Concept Program Development
Concept Adverse Drug Reaction Reporting Systems
Concept Pravastatin
Concept Serotonin Uptake Inhibitors
Concept Paroxetine
Concept Investigational New Drug Application
Concept Alternative Splicing
Concept Receptors, Opioid, mu
Concept DNA Primers
Concept DNA, Complementary
Concept Receptors, Cytoplasmic and Nuclear
Concept Antirheumatic Agents
Concept Gene Expression Regulation, Developmental
Concept Antidepressive Agents, Second-Generation
Concept Excitatory Amino Acid Antagonists
Concept Antimanic Agents
Concept Analgesics, Non-Narcotic
Concept Adrenergic Uptake Inhibitors
Concept Molecular Chaperones
Concept CpG Islands
Concept Anti-Allergic Agents
Concept Anti-Asthmatic Agents
Concept Anthracyclines
Concept Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept Buthionine Sulfoximine
Concept Lactic Acid
Concept Cytochrome P-450 CYP1A1
Concept Cytochrome P-450 CYP1A2
Concept Cytochrome P-450 CYP2D6
Concept Cytochrome P-450 CYP2E1
Concept Protein Disulfide-Isomerases
Concept Intramolecular Oxidoreductases
Concept Simvastatin
Concept Protective Agents
Concept Tyrphostins
Concept Protein Isoforms
Concept Tandem Repeat Sequences
Concept Cisapride
Concept Response Elements
Concept Sertraline
Concept Glucuronides
Concept DNA, Ribosomal Spacer
Concept Tacrolimus Binding Proteins
Concept RNA Splice Sites
Concept Mitochondrial Proteins
Concept E-Box Elements
Concept Membrane Transport Proteins
Concept Organic Anion Transporters
Concept Multidrug Resistance-Associated Proteins
Concept Organic Cation Transporter 1
Concept Organic Anion Transporters, Sodium-Independent
Concept Soybean Proteins
Concept Steroid 16-alpha-Hydroxylase
Concept Adolescent Development
Concept Methylenetetrahydrofolate Reductase (NADPH2)
Concept Carboxylesterase
Concept Fetal Development
Concept Retinoid X Receptors
Concept Phytoestrogens
Concept Betaine-Homocysteine S-Methyltransferase
Concept Wnt Proteins
Concept Toll-Like Receptors
Concept Toll-Like Receptor 2
Concept Toll-Like Receptor 4
Concept Aquaporin 1
Concept Aquaporin 2
Concept Cytochrome P-450 CYP3A
Concept Hepatocyte Nuclear Factor 4
Concept CCAAT-Enhancer-Binding Protein-delta
Concept Oseltamivir
Concept Janus Kinase 2
Concept 2-Pyridinylmethylsulfinylbenzimidazoles
Concept Proton Pump Inhibitors
Concept Nicotinamide Phosphoribosyltransferase
Concept Drug Dosage Calculations
Concept Lipocalins
Concept Prescription Drugs
Concept Antipyretics
Concept Drug Overdose
Concept Sulfonylurea Receptors
Concept Vitamin K Epoxide Reductases
Concept Drug-Related Side Effects and Adverse Reactions
Concept Cytochrome P-450 Enzyme Inhibitors
Concept Cytochrome P-450 CYP1A2 Inhibitors
Concept Cytochrome P-450 CYP1B1
Concept Cytochrome P-450 CYP2A6
Concept Cytochrome P-450 CYP2D6 Inhibitors
Concept Cytochrome P-450 CYP3A Inhibitors
Concept Cytochrome P-450 CYP2C9 Inducers
Concept Cytochrome P-450 CYP2B6
Concept Cytochrome P-450 CYP2C9
Concept Cytochrome P-450 CYP2C19
Academic Article Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article Fluorescence-based viability assay for studies of reactive drug intermediates.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article A method for meta-analysis of epidemiological studies.
Academic Article Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Academic Article Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Academic Article Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article Bendectin: the wrong way to regulate drug availability.
Academic Article Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article Biotransformation of fluticasone: in vitro characterization.
Academic Article Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article Application of pharmacogenomic strategies to the study of drug-induced birth defects.
Academic Article CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Academic Article Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Transcriptomic analysis of human lung development.
Academic Article Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.
Academic Article Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.
Academic Article Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article Drug metabolism for the paediatrician.
Academic Article VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article Individualizing the use of medications in children: making Goldilocks happy.
Academic Article Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Academic Article Acetaminophen overdose with therapeutic intent.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Over-the-Counter Medications: Update on Cough and Cold Preparations.
Academic Article In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Academic Article Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
Academic Article Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death.
Academic Article Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article Cytochrome P450 3A: ontogeny and drug disposition.
Academic Article Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article In vitro analysis of metabolic predisposition to drug hypersensitivity reactions.
Academic Article Aprepitant and fosaprepitant drug interactions: a systematic review.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Glucagon therapy for beta-blocker overdose.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article Considerations for Implementing Precision Therapeutics for Children.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article Optimization of gentamicin therapy in very low birth weight infants.
Academic Article Developmental aspects of drug metabolism in children
Academic Article Ontogeny of drug-metabolizing enzymes and its influence on the pathogenesis of adverse drug reactions in children
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article In: Handbook of Experimental Pharmacology Volume 121: Drug-Induced Hepatotoxicity. Cameron RG, Feuer G and de la Iglesia F, Eds
Academic Article In: Metabolic Drug Interactions, Levy RH, Thummel KE, Trager WF, Hansten PD and Eichelbaum M, eds
Academic Article In: Antiepileptic Drugs, 5th Edition, Levy RH et al, (Eds.)
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article In: Drug-Induced Liver Toxicity, 2nd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Drug-Induced Liver Toxicity, 3rd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant Clinical and Translational Mentored Career Development Award
Grant Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.
Academic Article Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Academic Article Recent advances in the ontogeny of drug disposition.
Academic Article Ontogeny of Drug-Metabolizing Enzymes.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article The Impact of Age and Genetics on Naltrexone Biotransformation.
Academic Article Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Academic Article Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Grant Ontogeny of drug transport
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children

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