 Metronidazole
"Metronidazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
| Descriptor ID |
D008795
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| MeSH Number(s) |
D02.640.672.500 D03.383.129.308.658.500
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| Concept/Terms |
Metronidazole- Metronidazole
- 2-Methyl-5-nitroimidazole-1-ethanol
- 2 Methyl 5 nitroimidazole 1 ethanol
Metronidazole Hydrochloride- Metronidazole Hydrochloride
- Hydrochloride, Metronidazole
- Metronidazole Monohydrochloride
- Monohydrochloride, Metronidazole
Metronidazole Phosphate- Metronidazole Phosphate
- Phosphate, Metronidazole
- Metronidazole Phosphoester
- Phosphoester, Metronidazole
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Below are MeSH descriptors whose meaning is more general than "Metronidazole".
Below are MeSH descriptors whose meaning is more specific than "Metronidazole".
This graph shows the total number of publications written about "Metronidazole" by people in this website by year, and whether "Metronidazole" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metronidazole" by people in Profiles.
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Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969.
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Stancil SL, van Haandel L, Abdel-Rahman S, Pearce RE. Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15; 1092:272-278.
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Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK, Kearns GL, Cohen-Wolkowiez M. Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. J Clin Pharmacol. 2017 02; 57(2):230-234.
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St Peter SD, Shah SR, Adibe OO, Sharp SW, Reading B, Cully B, Holcomb GW, Rivard DC. Saline vs Tissue Plasminogen Activator Irrigations after Drain Placement for Appendicitis-Associated Abscess: A Prospective Randomized Trial. J Am Coll Surg. 2015 Aug; 221(2):390-6.
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Desai AA, Alemayehu H, Holcomb GW, St Peter SD. Safety of a new protocol decreasing antibiotic utilization after laparoscopic appendectomy for perforated appendicitis in children: A prospective observational study. J Pediatr Surg. 2015 Jun; 50(6):912-4.
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Knott EM, Thomas P, Sharp NE, Gasior AC, St Peter SD. Reduced use of computed tomography in patients treated with interval appendectomy after implementing a protocol from a prospective, randomized trial. Pediatr Surg Int. 2013 Dec; 29(12):1293-6.
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Pearce RE, Cohen-Wolkowiez M, Sampson MR, Kearns GL. The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep; 41(9):1686-94.
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Wang X, Nanovskaya TN, Zhan Y, Abdel-Rahman SM, Jasek M, Hankins GD, Ahmed MS. Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. J Matern Fetal Neonatal Med. 2011 Mar; 24(3):444-8.
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Fraser JD, Aguayo P, Leys CM, Keckler SJ, Newland JG, Sharp SW, Murphy JP, Snyder CL, Sharp RJ, Andrews WS, Holcomb GW, Ostlie DJ, St Peter SD. A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial. J Pediatr Surg. 2010 Jun; 45(6):1198-202.
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St Peter SD, Tsao K, Spilde TL, Holcomb GW, Sharp SW, Murphy JP, Snyder CL, Sharp RJ, Andrews WS, Ostlie DJ. Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. J Pediatr Surg. 2008 Jun; 43(6):981-5.
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