 Arylamine N-Acetyltransferase
"Arylamine N-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.
| Descriptor ID |
D001191
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| MeSH Number(s) |
D08.811.913.050.134.138
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| Concept/Terms |
Arylamine N-Acetyltransferase- Arylamine N-Acetyltransferase
- Arylamine N Acetyltransferase
- N-Acetyltransferase, Arylamine
- Arylamine Acetyltransferases
- Acetyltransferases, Arylamine
- Arylamine Acetylases
- Acetylases, Arylamine
- Acetyl-CoA Arylamine N-Acetyltransferase
- Acetyl CoA Arylamine N Acetyltransferase
- Arylamine N-Acetyltransferase, Acetyl-CoA
- N-Acetyltransferase, Acetyl-CoA Arylamine
- Arylamine Acetylase
- Acetylase, Arylamine
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Below are MeSH descriptors whose meaning is more general than "Arylamine N-Acetyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Arylamine N-Acetyltransferase".
This graph shows the total number of publications written about "Arylamine N-Acetyltransferase" by people in this website by year, and whether "Arylamine N-Acetyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 |
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Below are the most recent publications written about "Arylamine N-Acetyltransferase" by people in Profiles.
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Goode EL, White KL, Vierkant RA, Phelan CM, Cunningham JM, Schildkraut JM, Berchuck A, Larson MC, Fridley BL, Olson JE, Webb PM, Chen X, Beesley J, Chenevix-Trench G, Sellers TA. Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. Mol Carcinog. 2011 May; 50(5):397-402.
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Jones AE, Brown KC, Werner RE, Gotzkowsky K, Gaedigk A, Blake M, Hein DW, van der Horst C, Kashuba AD. Variability in drug metabolizing enzyme activity in HIV-infected patients. Eur J Clin Pharmacol. 2010 May; 66(5):475-85.
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Kennedy MJ, Davis DA, Smith N, Gaedigk A, Pearce RE, Kearns GL. Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement. Clin Ther. 2008 Sep; 30(9):1687-99.
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Sugamori KS, Brenneman D, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R, Grant DM. Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse. Drug Metab Dispos. 2007 Jul; 35(7):1064-70.
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Ma JD, Nafziger AN, Villano SA, Gaedigk A, Bertino JS. Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults. Antimicrob Agents Chemother. 2006 Apr; 50(4):1130-5.
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Shelepova T, Nafziger AN, Victory J, Kashuba AD, Rowland E, Zhang Y, Sellers E, Kearns G, Leeder JS, Gaedigk A, Bertino JS. Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail. J Clin Pharmacol. 2005 Dec; 45(12):1413-21.
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Choi BH, Chae HD, Park TJ, Oh J, Lim J, Kang SS, Ha H, Kim KT. Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase. J Neurochem. 2004 Jul; 90(2):442-54.
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Kennedy MJ, Abdel-Rahman SM, Kashuba AD, Leeder JS. Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. J Clin Pharmacol. 2004 Jul; 44(7):708-14.
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Kennedy MJ, Scripture CD, Kashuba AD, Scott CS, Gaedigk A, Kearns GL. Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis. Clin Pharmacol Ther. 2004 Mar; 75(3):163-71.
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Sugamori KS, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R, Grant DM. Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice. Mol Pharmacol. 2003 Jul; 64(1):170-9.
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