Receptors, Cytoplasmic and Nuclear
"Receptors, Cytoplasmic and Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Descriptor ID |
D018160
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MeSH Number(s) |
D12.776.826
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Concept/Terms |
Receptors, Cytoplasmic and Nuclear- Receptors, Cytoplasmic and Nuclear
- Receptors, Cytosol and Nuclear
- Cytosolic and Nuclear Receptors
- Receptors, Nuclear and Cytoplasmic
- Cytoplasmic and Nuclear Receptors
- Cytosol and Nuclear Receptors
- Nuclear and Cytoplasmic Receptors
- Receptors, Cytosolic and Nuclear
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Below are MeSH descriptors whose meaning is more general than "Receptors, Cytoplasmic and Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Cytoplasmic and Nuclear".
This graph shows the total number of publications written about "Receptors, Cytoplasmic and Nuclear" by people in this website by year, and whether "Receptors, Cytoplasmic and Nuclear" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 | 2004 | 1 | 0 | 1 | 2005 | 1 | 0 | 1 | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Cytoplasmic and Nuclear" by people in Profiles.
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Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARa-Dependent Manner. Toxicol Sci. 2017 Dec 01; 160(2):351-360.
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Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD. Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicol Sci. 2016 06; 151(2):403-18.
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Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X. Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1a-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology. 2014 Apr; 146(4):1006-16.
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Bi C, Leeder JS, Vyhlidal CA. A comparative study on computational two-block motif detection: algorithms and applications. Mol Pharm. 2008 Jan-Feb; 5(1):3-16.
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Vyhlidal CA, Gaedigk R, Leeder JS. Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. Drug Metab Dispos. 2006 Jan; 34(1):131-7.
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Vyhlidal CA, Rogan PK, Leeder JS. Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation. J Biol Chem. 2004 Nov 05; 279(45):46779-86.
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Lane RH, Maclennan NK, Daood MJ, Hsu JL, Janke SM, Pham TD, Puri AR, Watchko JF. IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner. Pediatr Res. 2003 Jun; 53(6):994-1000.
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Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10939-43.
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