 Indomethacin
"Indomethacin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
| Descriptor ID |
D007213
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| MeSH Number(s) |
D03.438.473.420
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Indomethacin".
Below are MeSH descriptors whose meaning is more specific than "Indomethacin".
This graph shows the total number of publications written about "Indomethacin" by people in this website by year, and whether "Indomethacin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Indomethacin" by people in Profiles.
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Krzyzanski W, Stockard B, Gaedigk A, Scott A, Nolte W, Gibson K, Leeder JS, Lewis T. Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life. CPT Pharmacometrics Syst Pharmacol. 2023 01; 12(1):110-121.
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Lewis T, Van Haandel L, Scott A, Leeder JS. Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing. Pediatr Res. 2018 09; 84(3):325-327.
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Lewis TR, Shelton EL, Van Driest SL, Kannankeril PJ, Reese J. Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment. Semin Fetal Neonatal Med. 2018 08; 23(4):232-238.
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Rytting E, Nanovskaya TN, Wang X, Vernikovskaya DI, Clark SM, Cochran M, Abdel-Rahman SM, Venkataramanan R, Caritis SN, Hankins GD, Ahmed MS. Pharmacokinetics of indomethacin in pregnancy. Clin Pharmacokinet. 2014 Jun; 53(6):545-51.
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de Wildt SN, Kearns GL, Hop WC, Murry DJ, Abdel-Rahman SM, van den Anker JN. Pharmacokinetics and metabolism of intravenous midazolam in preterm infants. Clin Pharmacol Ther. 2001 Dec; 70(6):525-31.
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Hendrickson RJ, Cappadona C, Yankah EN, Sitzmann JV, Cahill PA, Redmond EM. Sustained pulsatile flow regulates endothelial nitric oxide synthase and cyclooxygenase expression in co-cultured vascular endothelial and smooth muscle cells. J Mol Cell Cardiol. 1999 Mar; 31(3):619-29.
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