Phenobarbital
"Phenobarbital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
| Descriptor ID |
D010634
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| MeSH Number(s) |
D03.383.742.698.253.650
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| Concept/Terms |
Phenobarbital- Phenobarbital
- Phenobarbitone
- Phenylethylbarbituric Acid
- Acid, Phenylethylbarbituric
- Phenemal
- Phenylbarbital
Phenobarbital Sodium- Phenobarbital Sodium
- Sodium, Phenobarbital
- Phenobarbital, Monosodium Salt
- Monosodium Salt Phenobarbital
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Below are MeSH descriptors whose meaning is more general than "Phenobarbital".
Below are MeSH descriptors whose meaning is more specific than "Phenobarbital".
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Below are the most recent publications written about "Phenobarbital" by people in Profiles.
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Lewis T, Kuye S, Sherman A. Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit. BMC Pediatr. 2018 06 20; 18(1):197.
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Riley RJ, Smith G, Wolf CR, Cook VA, Leeder JS. Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s) Biochem Biophys Res Commun. 1993 Feb 26; 191(1):32-40.
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Koren G, Lavi S, Greenwald M, Roifman C, Leeder JS, Gelfand EW, MacLeod SM. Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child. Clin Pharmacokinet. 1985 Jul-Aug; 10(4):371-5.