 Cytochrome P-450 CYP1A2
"Cytochrome P-450 CYP1A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
| Descriptor ID |
D019388
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| MeSH Number(s) |
D08.244.453.040.443 D08.811.682.690.708.170.040.443 D12.776.422.220.453.040.443
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| Concept/Terms |
Cytochrome P-450 CYP1A2- Cytochrome P-450 CYP1A2
- CYP1A2, Cytochrome P-450
- Cytochrome P 450 CYP1A2
- CYP 1A2
- CYP1A2
- Phenacetin O-Dealkylase
- O-Dealkylase, Phenacetin
- Phenacetin O Dealkylase
- Cytochrome P-450 LM4
- Cytochrome P 450 LM4
- P-450 LM4, Cytochrome
- Cytochrome P-450d
- Cytochrome P 450d
- Cytochrome P450 1A2
- Caffeine Demethylase
- Demethylase, Caffeine
- Cytochrome P-450 LM(4)
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP1A2".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP1A2".
This graph shows the total number of publications written about "Cytochrome P-450 CYP1A2" by people in this website by year, and whether "Cytochrome P-450 CYP1A2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2006 | 0 | 2 | 2 | | 2008 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cytochrome P-450 CYP1A2" by people in Profiles.
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Kennedy MJ, Davis DA, Smith N, Gaedigk A, Pearce RE, Kearns GL. Reduced activities of cytochrome P450 1A2 and xanthine oxidase in children with growth hormone deficiency. Clin Pharmacol Ther. 2008 Dec; 84(6):674-8.
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Kennedy MJ, Davis DA, Smith N, Gaedigk A, Pearce RE, Kearns GL. Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement. Clin Ther. 2008 Sep; 30(9):1687-99.
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Blake MJ, Abdel-Rahman SM, Pearce RE, Leeder JS, Kearns GL. Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res. 2006 Dec; 60(6):717-23.
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Ma JD, Nafziger AN, Villano SA, Gaedigk A, Bertino JS. Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults. Antimicrob Agents Chemother. 2006 Apr; 50(4):1130-5.
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Kennedy MJ, Abdel-Rahman SM, Kashuba AD, Leeder JS. Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. J Clin Pharmacol. 2004 Jul; 44(7):708-14.
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Kennedy MJ, Scripture CD, Kashuba AD, Scott CS, Gaedigk A, Kearns GL. Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis. Clin Pharmacol Ther. 2004 Mar; 75(3):163-71.
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Chainuvati S, Nafziger AN, Leeder JS, Gaedigk A, Kearns GL, Sellers E, Zhang Y, Kashuba AD, Rowland E, Bertino JS. Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail". Clin Pharmacol Ther. 2003 Nov; 74(5):437-47.
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Leeder JS. Pharmacogenetics and pharmacogenomics. Pediatr Clin North Am. 2001 Jun; 48(3):765-81.
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Streetman DS, Bleakley JF, Kim JS, Nafziger AN, Leeder JS, Gaedigk A, Gotschall R, Kearns GL, Bertino JS. Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail". Clin Pharmacol Ther. 2000 Oct; 68(4):375-83.
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Kashuba AD, Bertino JS, Kearns GL, Leeder JS, James AW, Gotschall R, Nafziger AN. Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping. Clin Pharmacol Ther. 1998 May; 63(5):540-51.
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