 Trimethoprim
"Trimethoprim" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
| Descriptor ID |
D014295
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| MeSH Number(s) |
D03.383.742.906
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trimethoprim".
Below are MeSH descriptors whose meaning is more specific than "Trimethoprim".
This graph shows the total number of publications written about "Trimethoprim" by people in this website by year, and whether "Trimethoprim" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trimethoprim" by people in Profiles.
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Feldman K, Suppes SL, Goldman JL. Clarification of adverse drug reactions by a pharmacovigilance team results in increased antibiotic re-prescribing at a freestanding United States children's hospital. PLoS One. 2024; 19(1):e0295410.
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Tessman RT, Nolte W, Toren P, Gibson K, Vu L, Goldman J. Simultaneous quantification of trimethoprim metabolites in pediatric plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 May 15; 1198:123232.
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Goldman JL, van Haandel L. Trimethoprim: The overlooked component of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions. Pharmacoepidemiol Drug Saf. 2018 08; 27(8):949-951.
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Goldman JL, Koen YM, Rogers SA, Li K, Leeder JS, Hanzlik RP. Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes. Drug Metab Dispos. 2016 10; 44(10):1603-7.
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Goldman JL, Leeder JS, Van Haandel L, Pearce RE. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep; 43(9):1372-80.
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van Haandel L, Goldman JL, Pearce RE, Leeder JS. Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children. Chem Res Toxicol. 2014 Feb 17; 27(2):211-8.
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