 Baclofen
"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
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| MeSH Number(s) |
D02.241.081.114.500.350.100
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| Concept/Terms |
Baclofen- Baclofen
- PCP-GABA
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- Baclophen
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
Baclospas- Baclospas
- Ashbourne Brand of Baclofen
- Baclofen Ashbourne Brand
Clofen- Clofen
- Alphapharm Brand of Baclofen
- Baclofen Alphapharm Brand
Apo-Baclofen- Apo-Baclofen
- Apo Baclofen
- ApoBaclofen
- Apotex Brand of Baclofen
- Baclofen Apotex Brand
PMS-Baclofen- PMS-Baclofen
- PMS Baclofen
- PMSBaclofen
- Pharmascience Brand of Baclofen
- Baclofen Pharmascience Brand
Ba-34,647- Ba-34,647
- Ba34,647
- CIBA-34,647-BA
- CIBA34,647BA
- Ba-34647
- Ba34647
Baclofen AWD- Baclofen AWD
- AWD, Baclofen
- ASTA Medica Brand of Baclofen
Lebic- Lebic
- Isis Brand of Baclofen
- Baclofen Isis Brand
Lioresal- Lioresal
- Novartis Brand of Baclofen
- Baclofen Novartis Brand
- Medtronic Brand of Baclofen
- Baclofen Medtronic Brand
- Ciba-Geigy Brand of Baclofen
- Baclofen Ciba-Geigy Brand
- Ciba Geigy Brand of Baclofen
- Liorésal
Nu-Baclo- Nu-Baclo
- Nu Baclo
- NuBaclo
- Nu-Pharm Brand of Baclofen
- Baclofen Nu-Pharm Brand
- Nu Pharm Brand of Baclofen
Baclofène-Irex- Baclofène-Irex
- Baclofène Irex
- BaclofèneIrex
- Irex Brand of Baclofen
- Baclofen Irex Brand
Atrofen- Atrofen
- Athena Brand of Baclofen
- Baclofen Athena Brand
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Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2020 | 2 | 0 | 2 | | 2023 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Baclofen" by people in Profiles.
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McLaughlin MJ, Fisher MT. A critical evaluation of oral baclofen in pediatric patients with cerebral palsy. J Pediatr Rehabil Med. 2023; 16(1):3-9.
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McLaughlin MJ, Ratnasingam D, McGhee E. Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy. Am J Phys Med Rehabil. 2020 05; 99(5):441-443.
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He Q, Chhonker YS, McLaughlin MJ, Murry DJ. Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 08; 25(2).
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Weinstein SM, McLaughlin M. Ask the Authors. PM R. 2018 03; 10(3):243-244.
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McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS. Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy. PM R. 2018 03; 10(3):235-243.
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He Y, Brunstrom-Hernandez JE, Thio LL, Lackey S, Gaebler-Spira D, Kuroda MM, Stashinko E, Hoon AH, Vargus-Adams J, Stevenson RD, Lowenhaupt S, McLaughlin JF, Christensen A, Dosa NP, Butler M, Schwabe A, Lopez C, Roge D, Kennedy D, Tilton A, Krach LE, Lewandowski A, Dai H, Gaedigk A, Leeder JS, Jusko WJ. Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. J Pediatr. 2014 May; 164(5):1181-1188.e8.
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