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Institution

J. Steven Leeder, PharmD, PhD

TitleDeputy Director, Children's Research Institute
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-6688-0504 Additional info
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    Other Positions
    TitleAssociate Chair-Research
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleMarion Merrell Dow Endowed Chair in Pediatric Precision Therapeutics
    InstitutionChildren's Mercy Kansas City
    DepartmentChildren's Research Institute

    TitleClinical Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics

    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics and Pharmacology

    TitleAdjunct Professor of Pharmacology, Toxicology and Therapeutics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPharmacology, Toxicology and Therapeutics

    TitleAdjunct Professor of Pharmaceutical Chemistry
    InstitutionUniversity of Kansas
    DepartmentPharmaceutical Chemistry


    Collapse Biography 
    Collapse education and training
    University of Minnesota, Minneapolis, MNPharmD1982
    University of Toronto, Toronto, Ontario, CanadaPhD1989
    The Hospital for Sick Children, Toronto, Ontario, Canada Fellowship1989Clinical Pharmacology
    Collapse awards and honors
    2021Clarivate Highly Cited Researcher – 2021, Pharmacology and Toxicology , Clarivate PLC
    2020Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics, Pediatric Pharmacy Association
    2019Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics
    2019Ingram’s 2019 Heroes in Healthcare, Ingram's Magazine
    2008Ninth Annual Charlotte Promersberger-Johnston Lectureship, Children’s Hospital of Wisconsin, Milwaukee, WI

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve.

    Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI.

    Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages.

    Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.
    Collapse research activities and funding
    R01HD081299     (PRASAD, BHAGWAT)Apr 1, 2015 - Jul 31, 2026
    NIH
    Ontogeny of drug transport
    Role: Co-Investigator
    P50HD090258     (LEEDER, JAMES STEVEN)Sep 23, 2016 - Jun 30, 2021
    NIH
    Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
    Role: Principal Investigator
    KL2TR002367     (WAGNER)Sep 1, 2017 - Dec 31, 2019
    NIH/NCRR
    Clinical and Translational Mentored Career Development Award
    Role: Primary Mentor
    2UL1TR002366     (CASTRO, MARIO; LEEDER JAMES STEVEN)Sep 7, 2017 - Jun 30, 2027
    NIH/NCATS
    Frontiers Clinical and Translational Science Institute at the University of Kansas
    Role: Co-Principal Investigator
    R01GM129783     (GOLDMAN, JENNIFER LYNN)Aug 1, 2018 - Jun 30, 2023
    NIH
    Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
    Role: Co-Investigator
    K23HD091362     (LEWIS, TAMORAH R.)Sep 25, 2018 - Aug 31, 2022
    NIH/NICHD
    Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
    Role: Co-Investigator
    R13TR003029     (LEEDER, JAMES STEVEN)Jul 15, 2019 - Jul 14, 2020
    NIH
    2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
    Role: Principal Investigator
    K23DK115827     (SHAKHNOVICH, VALENTINA)Jan 10, 2020 - Dec 31, 2024
    NIH
    Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
    Role: Primary Mentor
    1T32HD069038-11     (WAGNER, JONATHON)Mar 1, 2022
    NICHD
    Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
    Role: Co-Investigator, Senior Mentor

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wagner JB, Abdel-Rahman S, Raghuveer G, Gaedigk A, Boone EC, Gaedigk R, Staggs VS, Reed GA, Zhang N, Leeder JS. SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia. Genes (Basel). 2024 Jan 15; 15(1). PMID: 38254988.
      View in: PubMed
    2. Cheng S, Al-Kofahi M, Leeder JS, Brown JT. Population Pharmacokinetic Analysis of Atomoxetine and its Metabolites in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. Clin Pharmacol Ther. 2023 Dec 20. PMID: 38117180.
      View in: PubMed
    3. Zubiaur P, Leeder JS, Abad-Santos F, Gaedigk A. Response to "What is the Current Clinical Impact of the CYP2C:TG Haplotype?" Clin Pharmacol Ther. 2024 Feb; 115(2):184. PMID: 37970726.
      View in: PubMed
    4. Stancil SL, Pearce RE, Staggs VS, Leeder JS. Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver. Drug Metab Dispos. 2023 Dec; 51(12):1578-1582. PMID: 37735064.
      View in: PubMed
    5. Zubiaur P, Soria-Chacartegui P, Boone EC, Prasad B, Dinh J, Wang WY, Zugbi S, Rodr?guez-Lopez A, Gonz?lez-Iglesias E, Leeder JS, Abad-Santos F, Gaedigk A. Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity. Clin Pharmacol Ther. 2023 Nov; 114(5):1033-1042. PMID: 37528442.
      View in: PubMed
    6. Gelineau-Morel R, Smyser C, Leeder JS. Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach. Neurology. 2023 10 24; 101(17):752-759. PMID: 37463749.
      View in: PubMed
    7. Bousman CA, Stevenson JM, Ramsey LB, Sangkuhl K, Hicks JK, Strawn JR, Singh AB, Rua?o G, Mueller DJ, Tsermpini EE, Brown JT, Bell GC, Leeder JS, Gaedigk A, Scott SA, Klein TE, Caudle KE, Bishop JR. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clin Pharmacol Ther. 2023 07; 114(1):51-68. PMID: 37032427.
      View in: PubMed
    8. Krzyzanski W, Stockard B, Gaedigk A, Scott A, Nolte W, Gibson K, Leeder JS, Lewis T. Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life. CPT Pharmacometrics Syst Pharmacol. 2023 01; 12(1):110-121. PMID: 36309972.
      View in: PubMed
    9. Leeder JS, Gaedigk A, Wright KJ, Staggs VS, Soden SE, Lin YS, Pearce RE. A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence. Clin Transl Sci. 2022 Oct; 15(10):2514-2527. PMID: 35997001.
      View in: PubMed
    10. Behrle AC, Douglas J, Leeder JS, van Haandel L. Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic acid (SSDA) as a Urinary Biomarker of Cytochrome P450 2D6 (CYP2D6) Activity. Drug Metab Dispos. 2022 Jul 25. PMID: 35878926.
      View in: PubMed
    11. Chu X, Prasad B, Neuhoff S, Yoshida K, Leeder JS, Mukherjee D, Taskar K, Varma MVS, Zhang X, Yang X, Galetin A. Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clin Pharmacol Ther. 2022 09; 112(3):501-526. PMID: 35561140.
      View in: PubMed
    12. Cohen ASA, Farrow EG, Abdelmoity AT, Alaimo JT, Amudhavalli SM, Anderson JT, Bansal L, Bartik L, Baybayan P, Belden B, Berrios CD, Biswell RL, Buczkowicz P, Buske O, Chakraborty S, Cheung WA, Coffman KA, Cooper AM, Cross LA, Curran T, Dang TTT, Elfrink MM, Engleman KL, Fecske ED, Fieser C, Fitzgerald K, Fleming EA, Gadea RN, Gannon JL, Gelineau-Morel RN, Gibson M, Goldstein J, Grundberg E, Halpin K, Harvey BS, Heese BA, Hein W, Herd SM, Hughes SS, Ilyas M, Jacobson J, Jenkins JL, Jiang S, Johnston JJ, Keeler K, Korlach J, Kussmann J, Lambert C, Lawson C, Le Pichon JB, Leeder JS, Little VC, Louiselle DA, Lypka M, McDonald BD, Miller N, Modrcin A, Nair A, Neal SH, Oermann CM, Pacicca DM, Pawar K, Posey NL, Price N, Puckett LMB, Quezada JF, Raje N, Rowell WJ, Rush ET, Sampath V, Saunders CJ, Schwager C, Schwend RM, Shaffer E, Smail C, Soden S, Strenk ME, Sullivan BR, Sweeney BR, Tam-Williams JB, Walter AM, Welsh H, Wenger AM, Willig LK, Yan Y, Younger ST, Zhou D, Zion TN, Thiffault I, Pastinen T. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genet Med. 2022 06; 24(6):1336-1348. PMID: 35305867.
      View in: PubMed
    13. Hosey CM, Halpin K, Shakhnovich V, Bi C, Sweeney B, Yan Y, Leeder JS. Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models. Clin Transl Sci. 2022 04; 15(4):912-922. PMID: 35297172.
      View in: PubMed
    14. Ahire D, Basit A, Christopher LJ, Iyer R, Leeder JS, Prasad B. Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans. Drug Metab Dispos. 2022 03; 50(3):191-196. PMID: 34949674.
      View in: PubMed
    15. Leeder JS. Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future. J Pediatr Pharmacol Ther. 2022; 27(1):4-11. PMID: 35002553.
      View in: PubMed
    16. Dinh JC, Boone EC, Staggs VS, Pearce RE, Wang WY, Gaedigk R, Leeder JS, Gaedigk A. The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity. Clin Pharmacol Ther. 2022 03; 111(3):646-654. PMID: 34716917.
      View in: PubMed
    17. Stancil SL, Nolte W, Pearce RE, Staggs VS, Leeder JS. The Impact of Age and Genetics on Naltrexone Biotransformation. Drug Metab Dispos. 2022 02; 50(2):168-173. PMID: 34728519.
      View in: PubMed
    18. Leeder JS, Dinh JC, Gaedigk A, Staggs VS, Prasad B, Pearce RE. Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver. Drug Metab Dispos. 2022 01; 50(1):24-32. PMID: 34686522.
      View in: PubMed
    19. Hertz DL, Ramsey LB, Gopalakrishnan M, Leeder JS, Van Driest SL. Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics. Clin Pharmacol Ther. 2021 09; 110(3):589-594. PMID: 34043820.
      View in: PubMed
    20. Hosey-Cojocari C, Chan SS, Friesen CS, Robinson A, Williams V, Swanson E, O'Toole D, Radford J, Mardis N, Johnson TN, Leeder JS, Shakhnovich V. Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study. Clin Transl Sci. 2021 09; 14(5):2008-2016. PMID: 33982422.
      View in: PubMed
    21. Chapron BD, Chapron A, Leeder JS. Recent advances in the ontogeny of drug disposition. Br J Clin Pharmacol. 2022 10; 88(10):4267-4284. PMID: 33733546.
      View in: PubMed
    22. Crews KR, Monte AA, Huddart R, Caudle KE, Kharasch ED, Gaedigk A, Dunnenberger HM, Leeder JS, Callaghan JT, Samer CF, Klein TE, Haidar CE, Van Driest SL, Ruano G, Sangkuhl K, Cavallari LH, M?ller DJ, Prows CA, Nagy M, Somogyi AA, Skaar TC. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021 10; 110(4):888-896. PMID: 33387367.
      View in: PubMed
    23. Thakur A, Parvez MM, Leeder JS, Prasad B. Ontogeny of Drug-Metabolizing Enzymes. Methods Mol Biol. 2021; 2342:551-593. PMID: 34272706.
      View in: PubMed
    24. Sharma S, Kho AT, Chhabra D, Haley K, Vyhlidal C, Gaedigk R, Leeder JS, Tantisira KG, Raby B, Weiss ST. Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk. Healthcare (Basel). 2020 Dec 04; 8(4). PMID: 33291534.
      View in: PubMed
    25. Wilson CM, Li Q, Gaedigk R, Bi C, de Wildt SN, Leeder JS, Fridley BL. Ontogeny Related Changes in the Pediatric Liver Metabolome. Front Pediatr. 2020; 8:549. PMID: 33117761.
      View in: PubMed
    26. Wagner JB, Ruggiero M, Leeder JS, Hagenbuch B. Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport. Drug Metab Dispos. 2020 11; 48(11):1192-1198. PMID: 32892153.
      View in: PubMed
    27. Chapron BD, Dinh JC, Toren PC, Gaedigk A, Leeder JS. The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites. Drug Metab Dispos. 2020 11; 48(11):1113-1120. PMID: 32847865.
      View in: PubMed
    28. Boone EC, Wang WY, Gaedigk R, Cherner M, B?rard A, Leeder JS, Miller NA, Gaedigk A. Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions. Front Pharmacol. 2020; 11:486. PMID: 32457600.
      View in: PubMed
    29. Wagner JB, Abdel-Rahman S, Gaedigk A, Gaedigk R, Raghuveer G, Staggs VS, Van Haandel L, Leeder JS. Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia. Clin Transl Sci. 2020 05; 13(3):628-637. PMID: 31981411.
      View in: PubMed
    30. Zhang H, Basit A, Wolford C, Chen KF, Gaedigk A, Lin YS, Leeder JS, Prasad B. Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years. Clin Pharmacol Ther. 2020 05; 107(5):1149-1158. PMID: 31900930.
      View in: PubMed
    31. van Groen BD, Bi C, Gaedigk R, Staggs VS, Tibboel D, de Wildt SN, Leeder JS. Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver. Clin Transl Sci. 2020 05; 13(3):509-519. PMID: 31917523.
      View in: PubMed
    32. Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A. A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy. Clin Pharmacol Ther. 2020 01; 107(1):50-52. PMID: 31664715.
      View in: PubMed
    33. Maulik D, van Haandel L, Allsworth J, Chaisanguanthum KS, Yeast JD, Leeder JS. The effect of race and supplementation on maternal and umbilical cord plasma folates. J Matern Fetal Neonatal Med. 2021 Sep; 34(18):3057-3065. PMID: 31630592.
      View in: PubMed
    34. Leeder JS. Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data. Clin Pharmacol Ther. 2019 11; 106(5):939-941. PMID: 31509232.
      View in: PubMed
    35. Li CY, Hosey-Cojocari C, Basit A, Unadkat JD, Leeder JS, Prasad B. Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples. AAPS J. 2019 07 11; 21(5):88. PMID: 31297641.
      View in: PubMed
    36. Ogungbenro K, Wagner JB, Abdel-Rahman S, Leeder JS, Galetin A. A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents. Eur J Clin Pharmacol. 2019 Sep; 75(9):1227-1235. PMID: 31172248.
      View in: PubMed
    37. Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B. Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism. Drug Metab Dispos. 2019 08; 47(8):818-831. PMID: 31101678.
      View in: PubMed
    38. Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clin Pharmacol Ther. 2019 07; 106(1):94-102. PMID: 30801677.
      View in: PubMed
    39. Beck JN, Suppes SL, Smith CR, Lee BR, Leeder JS, VanDoren M, Newland JG, Goldman JL. Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children. J Pediatric Infect Dis Soc. 2019 Mar 28; 8(1):66-68. PMID: 29165624.
      View in: PubMed
    40. Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969. PMID: 30706508.
      View in: PubMed
    41. Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS. Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia. Clin Pharmacol Ther. 2019 06; 105(6):1501-1512. PMID: 30549267.
      View in: PubMed
    42. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 03; 12(2):140-150. PMID: 30516322.
      View in: PubMed
    43. McLaughlin MJ, Abdel-Rahman S, Leeder JS. Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy. Curr Phys Med Rehabil Rep. 2019 Mar; 7(1):40-45. PMID: 31579558.
      View in: PubMed
    44. McLaughlin MJ, Abdel-Rahman SM, Leeder JS. Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy. Curr Phys Med Rehab Rep. 2019.
    45. Lewis T, Leeder JS. Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier? Pharmacogenomics. 2018 11; 19(16):1231-1233. PMID: 30334480.
      View in: PubMed
    46. Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL. Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity. Pediatr Obes. 2019 01; 14(1). PMID: 30257076.
      View in: PubMed
    47. van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN. Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants. Eur J Pharm Sci. 2018 Nov 01; 124:217-227. PMID: 30171984.
      View in: PubMed
    48. Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B. Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver. Clin Pharmacol Ther. 2019 01; 105(1):131-141. PMID: 29737521.
      View in: PubMed
    49. Lewis T, Van Haandel L, Scott A, Leeder JS. Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing. Pediatr Res. 2018 09; 84(3):325-327. PMID: 29967531.
      View in: PubMed
    50. Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice. Am J Pathol. 2018 07; 188(7):1640-1652. PMID: 29684358.
      View in: PubMed
    51. Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS. Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics. J Pers Med. 2018 Apr 17; 8(2). PMID: 29673183.
      View in: PubMed
    52. Huddart R, Leeder JS, Altman RB, Klein TE. PharmGKB summary: clobazam pathway, pharmacokinetics. Pharmacogenet Genomics. 2018 04; 28(4):110-115. PMID: 29517622.
      View in: PubMed
    53. Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV. Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects. Clin Pharmacol Ther. 2018 05; 103(5):778-786. PMID: 29460415.
      View in: PubMed
    54. Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex. Drug Metab Dispos. 2018 06; 46(6):888-896. PMID: 29602798.
      View in: PubMed
    55. Meier R, Bi C, Gaedigk R, Heruth DP, Ye SQ, Leeder JS, Fridley BL. Ontogeny-related pharmacogene changes in the pediatric liver transcriptome. Pharmacogenet Genomics. 2018 03; 28(3):86-94. PMID: 29360682.
      View in: PubMed
    56. Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS. Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics. J Clin Pharmacol. 2018 06; 58(6):823-833. PMID: 29469964.
      View in: PubMed
    57. Petrikin JE, Cakici JA, Clark MM, Willig LK, Sweeney NM, Farrow EG, Saunders CJ, Thiffault I, Miller NA, Zellmer L, Herd SM, Holmes AM, Batalov S, Veeraraghavan N, Smith LD, Dimmock DP, Leeder JS, Kingsmore SF. The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants. NPJ Genom Med. 2018; 3:6. PMID: 29449963.
      View in: PubMed
    58. Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther. 2018 04; 365(1):96-106. PMID: 29420256.
      View in: PubMed
    59. Patel P, Leeder JS, Piquette-Miller M, Dupuis LL. Response to 'Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives'. Br J Clin Pharmacol. 2018 03; 84(3):604. PMID: 29315725.
      View in: PubMed
    60. Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE. The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database. Clin Pharmacol Ther. 2018 03; 103(3):399-401. PMID: 29134625.
      View in: PubMed
    61. Manolio TA, Hutter CM, Avigan M, Cibotti R, Davis RL, Denny JC, Grenade L, Wheatley LM, Carrington MN, Chantratita W, Chung WH, Dalton AD, Hung SI, Lee MTM, Leeder JS, Lertora JJL, Mahasirimongkol S, McLeod HL, Mockenhaupt M, Pacanowski M, Phillips EJ, Pinheiro S, Pirmohamed M, Sung C, Suwankesawong W, Trepanier L, Tumminia SJ, Veenstra D, Yuliwulandari R, Shear NH. Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis. Clin Pharmacol Ther. 2018 03; 103(3):390-394. PMID: 29105735.
      View in: PubMed
    62. Mirzakhani H, De Vivo I, Leeder JS, Gaedigk R, Vyhlidal CA, Weiss ST, Tantisira K. Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length. Eur J Obstet Gynecol Reprod Biol. 2017 Nov; 218:27-32. PMID: 28926727.
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    180. Grossman I, Sullivan PF, Walley N, Liu Y, Dawson JR, Gumbs C, Gaedigk A, Leeder JS, McEvoy JP, Weale ME, Goldstein DB. Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study. Genet Med. 2008 Oct; 10(10):720-9. PMID: 18813134.
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    183. Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS. Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metab Dispos. 2008 Aug; 36(8):1637-49. PMID: 18463198.
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    186. Bi C, Leeder JS, Vyhlidal CA. A comparative study on computational two-block motif detection: algorithms and applications. Mol Pharm. 2008 Jan-Feb; 5(1):3-16. PMID: 18076137.
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    245. Abdel-Rahman SM, Marcucci K, Boge T, Gotschall RR, Kearns GL, Leeder JS. Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine. Drug Metab Dispos. 1999 Jul; 27(7):770-5. PMID: 10383919.
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    246. de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin Pharmacokinet. 1999 Jun; 36(6):439-52. PMID: 10427468.
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    247. Abdel-Rahman SM, Gotschall RR, Kauffman RE, Leeder JS, Kearns GL. Investigation of terbinafine as a CYP2D6 inhibitor in vivo. Clin Pharmacol Ther. 1999 May; 65(5):465-72. PMID: 10340911.
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    248. Kearns GL, Leeder JS, Wasserman GS. Reply. J Pediatr. 1998 Nov; 133(5):713-714. PMID: 9822536.
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    249. Kashuba AD, Nafziger AN, Kearns GL, Leeder JS, Shirey CS, Gotschall R, Gaedigk A, Bertino JS. Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping. Pharmacogenetics. 1998 Oct; 8(5):403-10. PMID: 9825832.
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    250. Kashuba AD, Nafziger AN, Kearns GL, Leeder JS, Gotschall R, Rocci ML, Kulawy RW, Beck DJ, Bertino JS. Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping. Clin Pharmacol Ther. 1998 Sep; 64(3):257-68. PMID: 9757149.
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    251. Gaedigk A, Tyndale RF, Jurima-Romet M, Sellers EM, Grant DM, Leeder JS. NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations. Pharmacogenetics. 1998 Aug; 8(4):305-13. PMID: 9731717.
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    252. Henne KR, Gaedigk A, Gupta G, Leeder JS, Rettie AE. Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype. J Chromatogr B Biomed Sci Appl. 1998 Jun 12; 710(1-2):143-8. PMID: 9686881.
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    253. Leeder JS, Lu X, Timsit Y, Gaedigk A. Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions. Pharmacogenetics. 1998 Jun; 8(3):211-25. PMID: 9682267.
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    254. Gardner I, Leeder JS, Chin T, Zahid N, Uetrecht JP. A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo. Mol Pharmacol. 1998 Jun; 53(6):999-1008. PMID: 9614201.
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    255. Kashuba AD, Bertino JS, Kearns GL, Leeder JS, James AW, Gotschall R, Nafziger AN. Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping. Clin Pharmacol Ther. 1998 May; 63(5):540-51. PMID: 9630827.
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    256. Kearns GL, Leeder JS, Wasserman GS. Acetaminophen overdose with therapeutic intent. J Pediatr. 1998 Jan; 132(1):5-8. PMID: 9469992.
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    257. Leeder JS. Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs. Epilepsia. 1998; 39 Suppl 7:S8-16. PMID: 9798756.
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    258. Bradford LD, Gaedigk A, Leeder JS. High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998; 34(4):797-804. PMID: 10513455.
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    259. Gaedigk A, Leeder JS, Grant DM. Tissue-specific expression and alternative splicing of human microsomal epoxide hydrolase. DNA Cell Biol. 1997 Nov; 16(11):1257-66. PMID: 9406998.
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    260. Cribb AE, Pohl LR, Spielberg SP, Leeder JS. Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins. J Pharmacol Exp Ther. 1997 Aug; 282(2):1064-71. PMID: 9262376.
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    261. Leeder JS, Kearns GL. Pharmacogenetics in pediatrics. Implications for practice. Pediatr Clin North Am. 1997 Feb; 44(1):55-77. PMID: 9057784.
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    262. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature. 1996 Feb 15; 379(6566):645-8. PMID: 8628398.
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    263. Leeder JS, Gaedigk A, Lu X, Cook VA. Epitope mapping studies with human anti-cytochrome P450 3A antibodies. Mol Pharmacol. 1996 Feb; 49(2):234-43. PMID: 8632755.
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    264. Leeder JS and Okey AB. In: Handbook of Experimental Pharmacology Volume 121: Drug-Induced Hepatotoxicity. Cameron RG, Feuer G and de la Iglesia F, Eds. Cytochromes P450 and Liver Injury. Springer, Berlin. 1996; 119-153.
    265. Leeder JS:. Developmental aspects of drug metabolism in children. Drug Inform J. 1996; 30:1135-1143.
    266. Taddio A, Shennan AT, Stevens B, Leeder JS, Koren G. Safety of lidocaine-prilocaine cream in the treatment of preterm neonates. J Pediatr. 1995 Dec; 127(6):1002-5. PMID: 8523173.
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    267. Rajasenan RS, Riley RJ, Leeder JS. Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies. Toxicol Appl Pharmacol. 1995 Nov; 135(1):89-99. PMID: 7482543.
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    268. Taddio A, Ito S, Einarson TR, Leeder JS, Koren G. Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk. Reprod Toxicol. 1995 Mar-Apr; 9(2):153-7. PMID: 7795325.
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    269. Riley RJ, Leeder JS. In vitro analysis of metabolic predisposition to drug hypersensitivity reactions. Clin Exp Immunol. 1995 Jan; 99(1):1-6. PMID: 7813099.
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    270. Leeder JS, Cook VA and Riley RJ:. Anti-cytochrome P450 antibodies in patients with aromatic anticonvulsant-induced hypersensitivity reactions. in Cytochrome P450 Biochemistry, Biophysics and Molecular Biology, Lechner MC, ed. John Libbey Eurotext, Paris,. 1994; 197-200.
    271. Leeder JS and Spielberg SP. In: Maternal-Fetal Toxicology. A Clinician's Guide, 2nd edition Koren G, Ed. Teratogenicity and Litigation. 1994; 771-782.
    272. Donjon CM, Morkowski H, Cheung RK, Leeder JS, Dosch HM. Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence. J Immunol. 1993 Dec 01; 151(11):5948-54. PMID: 8245439.
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    273. Riley RJ, Spielberg SP, Leeder JS. A comparative study of the toxicity of chemically reactive xenobiotics towards adherent cell cultures: selective attenuation of menadione toxicity by buthionine sulphoximine pretreatment. J Pharm Pharmacol. 1993 Apr; 45(4):263-7. PMID: 8098365.
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    274. Riley RJ, Smith G, Wolf CR, Cook VA, Leeder JS. Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s) Biochem Biophys Res Commun. 1993 Feb 26; 191(1):32-40. PMID: 8447835.
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    275. Leeder JS, Riley RJ, Cook VA, Spielberg SP. Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions. J Pharmacol Exp Ther. 1992 Oct; 263(1):360-7. PMID: 1403797.
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    276. Chang H, Leeder JS, Cook VA, Patterson B, Dosch M, Minden MD and Messner HA:. Growth of human lymphoma cells in SCID mice. Leukemia and Lymphoma. 1992; 8:129-136.
    277. Cribb AE, Miller M, Leeder JS, Hill J, Spielberg SP. Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity. Drug Metab Dispos. 1991 Sep-Oct; 19(5):900-6. PMID: 1686233.
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    278. Dosch HM, Cochrane DM, Cook VA, Leeder JS, Cheung RK. Exogenous but not endogenous EBV induces lymphomas in beige/nude/xid mice carrying human lymphoid xenografts. Int Immunol. 1991 Jul; 3(7):731-5. PMID: 1655005.
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    279. Derewlany LO, Leeder JS, Kumar R, Radde IC, Knie B, Koren G. The transport of digoxin across the perfused human placental lobule. J Pharmacol Exp Ther. 1991 Mar; 256(3):1107-11. PMID: 2005575.
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    280. Leeder JS, Nakhooda A, Spielberg SP, Dosch HM. Cellular toxicity of sulfamethoxazole reactive metabolites--II. Inhibition of natural killer activity in human peripheral blood mononuclear cells. Biochem Pharmacol. 1991 Feb 15; 41(4):575-83. PMID: 1997006.
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    281. Leeder JS, Dosch HM, Spielberg SP. Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death. Biochem Pharmacol. 1991 Feb 15; 41(4):567-74. PMID: 1997005.
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    282. Riley RJ, Leeder JS, Dosch HM, Spielberg SP. Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology. Anal Biochem. 1990 Dec; 191(2):253-61. PMID: 2085171.
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    283. Koren G, Tesoro A, Leeder JS, Bentur Y and Olivieri N:. Studies of the stability of deferoxamine in aqueous solution. Can J Hosp Pharm. 1990; 43:57-60.
    284. Cribb AE, Leeder JS, Spielberg SP. Use of a microplate reader in an assay of glutathione reductase using 5,5'-dithiobis(2-nitrobenzoic acid). Anal Biochem. 1989 Nov 15; 183(1):195-6. PMID: 2619044.
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    285. Bentur Y, Koren G, Klein J, Tesoro A, Leeder JS. Pharmacokinetics of deferoxamine with and without iron load. Vet Hum Toxicol. 1989 Apr; 31(2):156-7. PMID: 2929124.
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    286. Leeder JS, Dosch HM, Harper PA, Lam P, Spielberg SP. Fluorescence-based viability assay for studies of reactive drug intermediates. Anal Biochem. 1989 Mar; 177(2):364-72. PMID: 2729556.
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    287. Tesoro A, Leeder JS, Bentur Y, Klein J, Freedman M, Koren G. A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids. Ther Drug Monit. 1989; 11(4):463-70. PMID: 2741196.
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    288. Leeder JS and Spielberg SP. In: Maternal-Fetal Toxicology. Koren G, Ed. Teratogenicity and Litigation. 1989; 415-425.
    289. Einarson TR, Leeder JS, Koren G. A method for meta-analysis of epidemiological studies. Drug Intell Clin Pharm. 1988 Oct; 22(10):813-24. PMID: 3229352.
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    290. Leeder JS, Cannon M, Nakhooda A, Spielberg SP. Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system. J Pharmacol Exp Ther. 1988 Jun; 245(3):956-62. PMID: 3385648.
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    291. Leeder JS and Gold R. In: Antimicrobial Therapy in Infants and Children. Koren G, Gold R and Prober C, Ed. Cephalosporins. Marcel Dekker, New York. 1988; 173-235.
    292. Mahon WA, Leeder JS, Brill-Edwards MM, Correia J, MacLeod SM. Comparative bioavailability study of three sustained release quinidine formulations. Clin Pharmacokinet. 1987 Aug; 13(2):118-24. PMID: 3621768.
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    293. Holland FJ, Fishman L, Costigan DC, Luna L, Leeder S. Pharmacokinetic characteristics of the gonadotropin-releasing hormone analog D-Ser(TBU)-6EA-10luteinizing hormone-releasing hormone (buserelin) after subcutaneous and intranasal administration in children with central precocious puberty. J Clin Endocrinol Metab. 1986 Nov; 63(5):1065-70. PMID: 3093518.
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    294. Leeder JS, Robertson C, Correia J, Isles AF, Levison H, Macleod SM. Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children. Ann Allergy. 1986 Feb; 56(2):133-7. PMID: 3946845.
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    295. Leeder JS, Isles AF, Robertson CF, Correia J, Levison H and MacLeod SM. In: Childhood Asthma and Sustained Release Theophylline. MacLeod SM and Szefler S, Eds. Assessment of beaded sustained release theophylline preparations. Excerpta Medica, Amsterdam. 1986; 114-126.
    296. Koren G, Lavi S, Greenwald M, Roifman C, Leeder JS, Gelfand EW, MacLeod SM. Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child. Clin Pharmacokinet. 1985 Jul-Aug; 10(4):371-5. PMID: 3899453.
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    297. Koren G, Leeder S, Harding E, Jacques D, MacLeod SM. Optimization of gentamicin therapy in very low birth weight infants. Pediatr Pharmacol (New York). 1985; 5(1):79-87. PMID: 3991255.
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    298. Leeder JS, Spino M, Isles AF, Tesoro AM, Gold R, MacLeod SM. Ceftazidime disposition in acute and stable cystic fibrosis. Clin Pharmacol Ther. 1984 Sep; 36(3):355-62. PMID: 6432400.
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    299. Peterson CD, Leeder JS, Sterner S. Glucagon therapy for beta-blocker overdose. Drug Intell Clin Pharm. 1984 May; 18(5):394-8. PMID: 6144498.
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    300. Leeder JS and MacLeod SM: . Acetaminophen overdose. Med North Amer. 1984; 2:1462-1464.
    301. Leeder JS: Minor side effects of OCs - . evaluation and management. On Cont Pract. 1984; 3(11):34-38.
    302. St. Pierre MV, Leeder JS, Spino M, Isles A and MacLeod SM:. Circadian variation in theophylline absorption. Ann Rev Chronopharmacol. 1984; 1:81-84.
    303. Isles AF, Leeder JS, Spino M and MacLeod SM. Bioavailability of Somophylline-CRT capsules. Br J Clin Pract. 1984; 35:68-70.
    304. Leeder JS, Tesoro AM, Bertho-Gebara CE and MacLeod SM. Comparative bioavailability of ranitidine tablets and suspension. Can J Hosp Pharm. 1984; 37:92-94.
    305. Leeder JS, Spielberg SP, MacLeod SM. Bendectin: the wrong way to regulate drug availability. Can Med Assoc J. 1983 Nov 15; 129(10):1085-7. PMID: 6627167.
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    306. Leeder JS, Spino M, Tesoro AM, MacLeod SM. High-pressure liquid chromatographic analysis of ceftazidime in serum and urine. Antimicrob Agents Chemother. 1983 Nov; 24(5):720-4. PMID: 6362554.
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