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research overview Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the Director of the Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

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Concept Abnormalities, Drug-Induced
Concept Acetaminophen
Concept Acetyltransferases
Concept Adrenal Cortex Hormones
Concept Adrenergic beta-Antagonists
Concept Alcohol Dehydrogenase
Concept Aldehyde Dehydrogenase
Concept Alkynes
Concept Amines
Concept Aminobiphenyl Compounds
Concept Amitriptyline
Concept Central Nervous System Stimulants
Concept Analgesics, Opioid
Concept Androgens
Concept Anti-Arrhythmia Agents
Concept Anti-Infective Agents, Local
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Anti-Ulcer Agents
Concept Antibodies
Concept Anticoagulants
Concept Anticonvulsants
Concept Antidepressive Agents
Concept Antidepressive Agents, Tricyclic
Concept Antiemetics
Concept Antifibrinolytic Agents
Concept Epitopes
Concept Antimalarials
Concept Antimetabolites
Concept Antitussive Agents
Concept Antiviral Agents
Concept Aryl Hydrocarbon Hydroxylases
Concept Arylamine N-Acetyltransferase
Concept Autoantigens
Concept Baclofen
Concept Base Sequence
Concept Benzimidazoles
Concept Binding Sites
Concept Binding Sites, Antibody
Concept Caffeine
Concept Carbamazepine
Concept Carbon Dioxide
Concept Carbon Isotopes
Concept Carboxy-Lyases
Concept Carboxylic Ester Hydrolases
Concept Carcinogens
Concept Carrier Proteins
Concept Catechol O-Methyltransferase
Concept Catecholamines
Concept Clotrimazole
Concept Codeine
Concept Contraceptives, Oral
Concept Crystallization
Concept Cyclopropanes
Concept Cytochrome P-450 Enzyme System
Concept Debrisoquin
Concept Dehydroepiandrosterone
Concept Dextromethorphan
Concept Dextrorphan
Concept Disulfides
Concept DNA
Concept DNA, Fungal
Concept DNA, Ribosomal
Concept Dopamine
Concept Dose-Response Relationship, Drug
Concept Drug Administration Schedule
Concept Drug Combinations
Concept Drug Hypersensitivity
Concept Drug Interactions
Concept Drug Labeling
Concept Drug Resistance
Concept Pharmaceutical Preparations
Concept Enzyme Inhibitors
Concept Epoxide Hydrolases
Concept Ethanolamines
Concept Ethinyl Estradiol
Concept Exons
Concept Fatty Acids, Monounsaturated
Concept Fluorenes
Concept Fluoxetine
Concept Fungal Proteins
Concept Haptens
Concept Heterocyclic Compounds
Concept Amine Oxidase (Copper-Containing)
Concept Histamine
Concept HLA Antigens
Concept Mixed Function Oxygenases
Concept Hypnotics and Sedatives
Concept Immunosuppressive Agents
Concept Indoles
Concept Insulin-Like Growth Factor I
Concept Introns
Concept Isoenzymes
Concept Luciferases
Concept Membrane Proteins
Concept Methamphetamine
Concept Metoprolol
Concept Midazolam
Concept Morphine
Concept Muscle Relaxants, Central
Concept NADPH-Ferrihemoprotein Reductase
Concept Neoplasm Proteins
Concept Nitrophenols
Concept Norgestrel
Concept Nuclear Proteins
Concept Omeprazole
Concept Oxidoreductases, N-Demethylating
Concept Oxygenases
Concept Aminosalicylic Acid
Concept Peptide Fragments
Concept Phenylethyl Alcohol
Concept Phenols
Concept Phenytoin
Concept Phosphoadenosine Phosphosulfate
Concept Phosphodiesterase Inhibitors
Concept Pimozide
Concept Plasmids
Concept Drug Prescriptions
Concept Primaquine
Concept Promoter Regions, Genetic
Concept Propafenone
Concept Propylamines
Concept Proteins
Concept Pyrimidinones
Concept Pyrophosphatases
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Reference Standards
Concept Ribonucleosides
Concept Rifampin
Concept RNA
Concept RNA, Fungal
Concept RNA, Messenger
Concept RNA, Ribosomal
Concept Growth Hormone
Concept Sparteine
Concept Stereoisomerism
Concept Steroid Hydroxylases
Concept Sulfamethazine
Concept Sulfates
Concept Tamoxifen
Concept Testosterone
Concept Thromboxane-A Synthase
Concept Tramadol
Concept Antipsychotic Agents
Concept Anti-Anxiety Agents
Concept Tumor Necrosis Factor-alpha
Concept Glucuronosyltransferase
Concept Vancomycin
Concept Vitamin K
Concept Vitamins
Concept Warfarin
Concept Xanthine Oxidase
Concept Zidovudine
Concept HLA-B Antigens
Concept Sulfotransferases
Concept Arylsulfotransferase
Concept Deoxyribonucleases, Type II Site-Specific
Concept Xenobiotics
Concept Citalopram
Concept RNA Probes
Concept Gene Library
Concept Minor Histocompatibility Antigens
Concept Interleukin-6
Concept Tacrolimus
Concept Bupropion
Concept NAD(P)H Dehydrogenase (Quinone)
Concept Fluvoxamine
Concept Cyclooxygenase Inhibitors
Concept Drug Monitoring
Concept Pravastatin
Concept Ondansetron
Concept HIV Protease Inhibitors
Concept Serotonin Uptake Inhibitors
Concept Paroxetine
Concept Alternative Splicing
Concept Receptors, Opioid, mu
Concept DNA Primers
Concept DNA, Complementary
Concept Gene Expression Regulation, Developmental
Concept Antidepressive Agents, Second-Generation
Concept Excitatory Amino Acid Antagonists
Concept Analgesics, Non-Narcotic
Concept Adrenergic Uptake Inhibitors
Concept Antineoplastic Agents, Hormonal
Concept Risperidone
Concept Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept Anti-HIV Agents
Concept Human Growth Hormone
Concept Cytochrome P-450 CYP1A2
Concept Cytochrome P-450 CYP2D6
Concept Cytochrome P-450 CYP2E1
Concept Ritonavir
Concept Intramolecular Oxidoreductases
Concept Simvastatin
Concept Tandem Repeat Sequences
Concept Natriuretic Peptide, Brain
Concept Sertraline
Concept 3' Untranslated Regions
Concept Glucuronides
Concept DNA, Intergenic
Concept Amino Acid Transport Systems
Concept Amino Acid Transport System A
Concept Multidrug Resistance-Associated Proteins
Concept Organic Cation Transporter 1
Concept Organic Anion Transporters, Sodium-Independent
Concept Drosophila Proteins
Concept MicroRNAs
Concept Steroid 16-alpha-Hydroxylase
Concept Carboxylesterase
Concept Benzoxazines
Concept Cytochrome P-450 CYP3A
Concept Hepatocyte Nuclear Factor 4
Concept Oseltamivir
Concept 2-Pyridinylmethylsulfinylbenzimidazoles
Concept Proton Pump Inhibitors
Concept Drug Dosage Calculations
Concept Prescription Drugs
Concept Serotonin 5-HT3 Receptor Agonists
Concept Lopinavir
Concept Sulfonylurea Receptors
Concept Vitamin K Epoxide Reductases
Concept Drug-Related Side Effects and Adverse Reactions
Concept Cytochrome P-450 Enzyme Inhibitors
Concept Cytochrome P-450 CYP2A6
Concept Cytochrome P-450 CYP2D6 Inhibitors
Concept Cytochrome P-450 CYP2B6 Inducers
Concept Cytochrome P-450 CYP2B6
Concept Cytochrome P-450 CYP2C8
Concept Cytochrome P-450 CYP2C9
Concept Cytochrome P-450 CYP2C19
Academic Article Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Academic Article Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
Academic Article Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Academic Article Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
Academic Article Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Academic Article Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Academic Article Variability in drug metabolizing enzyme activity in HIV-infected patients.
Academic Article Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.
Academic Article Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Academic Article In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4a expression.
Academic Article Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
Academic Article Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.
Academic Article Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article Regulation of microRNA expression by rifampin in human hepatocytes.
Academic Article Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article CYP450 genotype and pharmacogenetic association studies: a critical appraisal.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes.
Academic Article Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article Interethnic differences of drug-metabolizing enzymes.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article Pharmacogenetics: Chasing Perfection.
Grant PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
Grant Regulation of drug metabolizing enzymes by miRNAs
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Regulation of drug metabolizing enzymes by miRNAs
Academic Article CRC Press/Taylor & Francis Group, Ye, S.Q. (ed.)
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.
Academic Article The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital.
Academic Article Review and Consensus on Pharmacogenomic Testing in Psychiatry.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy.

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