 Cytochrome P-450 CYP2C8
"Cytochrome P-450 CYP2C8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
| Descriptor ID |
D065727
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| MeSH Number(s) |
D08.244.453.040.590 D08.811.682.690.708.170.040.590 D12.776.422.220.453.040.590
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| Concept/Terms |
Cytochrome P-450 CYP2C8- Cytochrome P-450 CYP2C8
- CYP2C8, Cytochrome P-450
- Cytochrome P 450 CYP2C8
- P-450 CYP2C8, Cytochrome
- S-Mephenytoin 4-Hydroxylase
- 4-Hydroxylase, S-Mephenytoin
- S Mephenytoin 4 Hydroxylase
- Cytochrome P450 MP-20
- Cytochrome P450 MP 20
- P450 MP-20, Cytochrome
- Cytochrome P450, Family 2, Subfamily C, Polypeptide 8
- CYP2C8
- CYPIIC8
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2C8".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2C8".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2C8" by people in this website by year, and whether "Cytochrome P-450 CYP2C8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2C8" by people in Profiles.
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Gaedigk A, Boone EC, Scherer SE, Lee SB, Numanagic I, Sahinalp C, Smith JD, McGee S, Radhakrishnan A, Qin X, Wang WY, Farrow EG, Gonzaludo N, Halpern AL, Nickerson DA, Miller NA, Pratt VM, Kalman LV. CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project. J Mol Diagn. 2022 04; 24(4):337-350.
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Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos. 2006 Jan; 34(1):191-7.
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