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Last Name
Institution

Tomoo Iwakuma

Concepts (354)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Tumor Suppressor Protein p53
32
2024
41
9.230
Why?
Neoplasms
15
2024
128
3.950
Why?
Bone Neoplasms
10
2019
23
3.330
Why?
Animals
52
2024
729
3.120
Why?
Osteosarcoma
11
2020
19
3.020
Why?
Mutation
13
2024
212
2.450
Why?
Mice
39
2023
348
2.330
Why?
HSP40 Heat-Shock Proteins
3
2021
5
2.140
Why?
Carrier Proteins
7
2015
35
2.090
Why?
Proto-Oncogene Proteins c-mdm2
13
2024
14
1.860
Why?
Humans
52
2024
6896
1.680
Why?
Cell Movement
8
2016
71
1.490
Why?
Mutant Proteins
4
2021
6
1.480
Why?
Signal Transduction
11
2021
132
1.400
Why?
Lung Neoplasms
5
2016
23
1.310
Why?
Neoplasm Metastasis
9
2021
19
1.300
Why?
Cell Line, Tumor
18
2024
99
1.300
Why?
Liver Neoplasms
6
2020
15
1.300
Why?
Apoptosis
12
2023
52
1.260
Why?
Gene Expression Regulation, Neoplastic
8
2019
59
1.190
Why?
Membrane Proteins
3
2021
54
1.170
Why?
Receptor, Adenosine A3
2
2017
2
1.150
Why?
Actinin
3
2015
3
1.020
Why?
Cell Transformation, Neoplastic
7
2021
16
0.960
Why?
Carcinogenesis
3
2021
9
0.900
Why?
Biomarkers, Tumor
3
2021
65
0.890
Why?
RNA, Small Interfering
6
2017
22
0.800
Why?
Mevalonic Acid
2
2017
2
0.750
Why?
Disease Models, Animal
7
2021
71
0.750
Why?
Pancreatic Neoplasms
5
2020
13
0.730
Why?
Carcinoma, Squamous Cell
1
2020
4
0.730
Why?
Skin Neoplasms
1
2020
11
0.720
Why?
Lipid Metabolism
2
2017
9
0.720
Why?
MicroRNAs
1
2020
27
0.710
Why?
Proto-Oncogene Proteins
5
2011
18
0.690
Why?
Sarcoma
1
2019
6
0.680
Why?
Soft Tissue Neoplasms
1
2019
6
0.680
Why?
Cell Cycle Checkpoints
2
2019
4
0.670
Why?
Tumor Suppressor Proteins
3
2020
15
0.620
Why?
Mutation, Missense
1
2018
28
0.620
Why?
NF-kappa B
2
2016
14
0.590
Why?
Cell Death
1
2016
4
0.570
Why?
Nuclear Proteins
4
2010
52
0.570
Why?
Membrane Glycoproteins
1
2016
14
0.560
Why?
Cell Proliferation
9
2020
58
0.560
Why?
Oncogenes
2
2021
3
0.540
Why?
Peptide Hydrolases
2
2012
2
0.530
Why?
Multiprotein Complexes
2
2012
4
0.520
Why?
Injections
1
2015
5
0.520
Why?
Femur
1
2015
10
0.520
Why?
Carcinoma, Hepatocellular
2
2015
4
0.520
Why?
RNA, Messenger
7
2024
115
0.480
Why?
Gene Knockdown Techniques
5
2021
13
0.450
Why?
Receptor, ErbB-2
1
2012
4
0.430
Why?
Proto-Oncogene Proteins c-akt
1
2012
8
0.430
Why?
Disease Progression
3
2021
111
0.430
Why?
Genes, p53
3
2010
5
0.430
Why?
Neoplasm Invasiveness
4
2020
29
0.410
Why?
Pseudopodia
1
2012
6
0.410
Why?
Li-Fraumeni Syndrome
3
2009
3
0.410
Why?
Male
13
2023
3337
0.380
Why?
Chromosome Segregation
1
2011
2
0.380
Why?
Mitosis
1
2011
2
0.380
Why?
Antigens, Surface
1
2010
2
0.360
Why?
Proto-Oncogene Proteins c-kit
1
2010
5
0.360
Why?
Carcinoma, Pancreatic Ductal
2
2020
3
0.360
Why?
Mice, Knockout
8
2023
59
0.350
Why?
Mice, Nude
4
2017
10
0.340
Why?
Female
13
2021
3525
0.330
Why?
Proteinase Inhibitory Proteins, Secretory
2
2020
2
0.330
Why?
Intracellular Signaling Peptides and Proteins
2
2019
21
0.320
Why?
Serine
2
2004
2
0.310
Why?
Gene Expression
4
2021
67
0.310
Why?
Ubiquitination
4
2019
7
0.290
Why?
Protein Isoforms
2
2017
16
0.290
Why?
Protein Processing, Post-Translational
3
2014
6
0.270
Why?
Phosphoric Monoester Hydrolases
2
2023
2
0.270
Why?
Gene Silencing
3
2019
13
0.260
Why?
Tumor Cells, Cultured
5
2017
25
0.260
Why?
Xenograft Model Antitumor Assays
4
2019
15
0.260
Why?
Multigene Family
1
2005
8
0.260
Why?
Genetic Vectors
3
1999
9
0.260
Why?
DNA
3
2023
41
0.250
Why?
O(6)-Methylguanine-DNA Methyltransferase
3
2023
3
0.250
Why?
Down-Regulation
3
2016
15
0.250
Why?
Heterografts
2
2021
3
0.240
Why?
Ubiquitin-Protein Ligases
3
2011
11
0.240
Why?
Asia
1
2024
10
0.240
Why?
Proteolysis
2
2021
3
0.240
Why?
RNA Interference
2
2016
16
0.240
Why?
Kisspeptins
2
2014
2
0.230
Why?
Polyphosphates
1
2023
1
0.230
Why?
Glucagon-Like Peptide 1
1
2023
2
0.230
Why?
Neoplasm Staging
2
2021
33
0.230
Why?
Neoplasm Proteins
2
2016
31
0.230
Why?
Reverse Transcriptase Polymerase Chain Reaction
3
2016
71
0.230
Why?
Glioblastoma
1
2023
17
0.230
Why?
Diabetes Mellitus, Type 2
1
2023
39
0.220
Why?
Protein Binding
3
2019
31
0.220
Why?
Adaptor Proteins, Signal Transducing
2
2021
41
0.210
Why?
Aged
3
2023
378
0.200
Why?
cdc42 GTP-Binding Protein
1
2021
1
0.200
Why?
rac1 GTP-Binding Protein
1
2021
2
0.200
Why?
Unfolded Protein Response
1
2021
3
0.200
Why?
Disease Susceptibility
1
2021
11
0.200
Why?
Desmosomes
1
2021
1
0.200
Why?
Arrhythmogenic Right Ventricular Dysplasia
1
2021
3
0.190
Why?
Proteome
1
2021
3
0.190
Why?
Adult
3
2017
1181
0.190
Why?
DNA Damage
3
2012
9
0.190
Why?
Mice, Inbred C57BL
6
2012
92
0.190
Why?
Immunity, Innate
1
2021
16
0.190
Why?
ATP-Binding Cassette Transporters
2
2011
4
0.190
Why?
Aurora Kinase A
1
2020
3
0.180
Why?
Middle Aged
3
2019
608
0.180
Why?
STAT5 Transcription Factor
1
2020
6
0.180
Why?
Pimozide
1
2020
4
0.180
Why?
Mice, Transgenic
6
2011
35
0.180
Why?
DNA Repair
2
2009
3
0.170
Why?
Neoplasms, Experimental
2
2008
2
0.170
Why?
Terminal Repeat Sequences
1
1999
1
0.170
Why?
Jumonji Domain-Containing Histone Demethylases
1
2019
3
0.170
Why?
Lentivirus
1
1999
4
0.170
Why?
Blotting, Western
3
2016
17
0.170
Why?
Electron Transport Complex III
1
2019
1
0.170
Why?
Antineoplastic Agents
2
2018
55
0.160
Why?
Phenotype
4
2008
257
0.160
Why?
Drug Repositioning
1
2018
3
0.160
Why?
Amino Acid Substitution
1
2018
12
0.160
Why?
Drug Screening Assays, Antitumor
1
2018
7
0.160
Why?
Gluconeogenesis
1
2017
1
0.150
Why?
AMP-Activated Protein Kinases
1
2017
2
0.150
Why?
Liver
2
2017
126
0.150
Why?
Doxorubicin
3
2010
15
0.150
Why?
Methyltransferases
1
1997
9
0.150
Why?
Energy Metabolism
1
2017
26
0.150
Why?
DNA, Complementary
1
2017
9
0.150
Why?
Drug Resistance, Neoplasm
2
2023
26
0.150
Why?
Necrosis
1
2016
2
0.140
Why?
Pyroptosis
1
2016
4
0.140
Why?
Autophagy
1
2016
2
0.140
Why?
Promoter Regions, Genetic
4
2019
49
0.140
Why?
Neoplastic Stem Cells
2
2020
11
0.140
Why?
Up-Regulation
2
2019
25
0.140
Why?
Genome, Human
1
2017
86
0.140
Why?
Fibroblasts
3
2004
26
0.140
Why?
Lung
1
2016
65
0.140
Why?
Imidazoles
1
2016
2
0.130
Why?
Genes, Dominant
1
2016
5
0.130
Why?
Immunoenzyme Techniques
1
2016
9
0.130
Why?
Cell Adhesion
1
2016
9
0.130
Why?
Piperazines
1
2016
3
0.130
Why?
Alleles
2
2016
214
0.130
Why?
Real-Time Polymerase Chain Reaction
1
2016
41
0.130
Why?
Genome-Wide Association Study
1
2016
190
0.130
Why?
Tissue Fixation
1
2015
2
0.130
Why?
Transplantation, Heterologous
1
2015
6
0.130
Why?
Histone Deacetylase Inhibitors
1
2015
4
0.130
Why?
Neoplasm Transplantation
1
2015
8
0.130
Why?
HIV-1
3
1999
26
0.120
Why?
Ultraviolet Rays
2
2004
5
0.120
Why?
Furin
1
2014
1
0.120
Why?
Breast Neoplasms
2
2011
38
0.120
Why?
Mitochondria
1
2013
11
0.120
Why?
Stomach Neoplasms
2
2011
7
0.110
Why?
Antibiotics, Antineoplastic
2
2010
7
0.110
Why?
DNA Repair Enzymes
2
2023
2
0.100
Why?
Young Adult
1
2015
647
0.100
Why?
Mice, Inbred NOD
1
2012
7
0.100
Why?
Actins
1
2012
5
0.100
Why?
Cell Nucleus
1
2012
7
0.100
Why?
Mice, SCID
1
2012
13
0.100
Why?
Thymocytes
1
2012
1
0.100
Why?
Receptors, Interleukin-7
1
2012
2
0.100
Why?
Telomere
1
2012
3
0.100
Why?
Models, Biological
2
2019
65
0.100
Why?
Blotting, Southern
2
2011
2
0.100
Why?
Protein Multimerization
1
2011
3
0.100
Why?
Embryonic Development
1
2011
13
0.100
Why?
Cell Cycle
3
2007
18
0.100
Why?
Interleukin-17
1
2011
1
0.100
Why?
Autoimmunity
1
2011
4
0.100
Why?
STAT3 Transcription Factor
1
2011
7
0.100
Why?
Metaphase
1
2011
1
0.100
Why?
Kinetochores
1
2011
1
0.100
Why?
Mad2 Proteins
1
2011
1
0.100
Why?
Gene Expression Regulation, Developmental
1
2011
51
0.100
Why?
Aneuploidy
1
2011
4
0.100
Why?
Repressor Proteins
1
2011
12
0.090
Why?
Aldehyde Dehydrogenase
1
2011
3
0.090
Why?
Cell Separation
1
2011
7
0.090
Why?
Calcium-Binding Proteins
1
2011
10
0.090
Why?
Cell Cycle Proteins
1
2011
18
0.090
Why?
Rats
4
2023
106
0.090
Why?
Cells, Cultured
5
2010
84
0.090
Why?
Prostatic Neoplasms
1
2011
34
0.090
Why?
Receptors, CXCR4
1
2010
5
0.090
Why?
Genes, myc
1
2010
1
0.090
Why?
Lymphoma, B-Cell
1
2010
1
0.090
Why?
B-Lymphocytes
1
2010
24
0.090
Why?
Transcription Factors
2
2024
52
0.090
Why?
DNA-(Apurinic or Apyrimidinic Site) Lyase
1
2009
1
0.080
Why?
Transcription, Genetic
2
2008
44
0.080
Why?
Genes, p16
1
2008
1
0.080
Why?
Adolescent
1
2015
2197
0.080
Why?
Cell Survival
2
2018
20
0.080
Why?
DNA-Binding Proteins
3
2012
39
0.080
Why?
High-Throughput Screening Assays
2
2018
4
0.080
Why?
Protein Structure, Tertiary
1
2007
14
0.070
Why?
Gene Expression Regulation
2
2004
101
0.070
Why?
Pregnancy
1
2007
216
0.070
Why?
Glucose
2
2017
22
0.070
Why?
Child
1
2015
3364
0.070
Why?
Survival Analysis
2
2019
50
0.060
Why?
Cell Line
2
2017
81
0.060
Why?
Fetal Death
1
2004
3
0.060
Why?
Point Mutation
1
2004
7
0.060
Why?
Mutagenesis, Site-Directed
1
2004
19
0.060
Why?
Deoxyguanosine
1
2023
1
0.060
Why?
Nucleosides
1
2023
1
0.060
Why?
Antineoplastic Agents, Alkylating
1
2023
1
0.060
Why?
Caspases
1
2023
2
0.060
Why?
Enteroendocrine Cells
1
2023
1
0.060
Why?
Hepatocyte Nuclear Factor 3-alpha
1
2023
1
0.060
Why?
Rats, Wistar
1
2023
2
0.060
Why?
Nucleotides
1
2023
2
0.060
Why?
Deoxyguanine Nucleotides
1
2023
2
0.050
Why?
S Phase
1
2023
3
0.050
Why?
Mutagenesis
2
1999
5
0.050
Why?
Trans-Activators
2
2004
14
0.050
Why?
Survival Rate
2
2017
83
0.050
Why?
Polymerase Chain Reaction
2
1999
84
0.050
Why?
Nucleotidyltransferases
1
2021
1
0.050
Why?
Cytosol
1
2021
14
0.050
Why?
G1 Phase Cell Cycle Checkpoints
1
2020
1
0.040
Why?
Small Ubiquitin-Related Modifier Proteins
1
1999
1
0.040
Why?
RNA Helicases
1
1999
2
0.040
Why?
Virus Integration
1
1999
1
0.040
Why?
Cytomegalovirus
1
1999
2
0.040
Why?
Immediate-Early Proteins
1
1999
2
0.040
Why?
Proviruses
1
1999
2
0.040
Why?
Transduction, Genetic
1
1999
3
0.040
Why?
Datasets as Topic
1
2019
7
0.040
Why?
Plasmids
1
1999
5
0.040
Why?
Transfection
1
1999
22
0.040
Why?
Cattle
1
1999
24
0.040
Why?
Human Growth Hormone
1
1999
15
0.040
Why?
DNA, Viral
1
1999
13
0.040
Why?
Enhancer Elements, Genetic
1
1999
19
0.040
Why?
RNA, Viral
1
1999
13
0.040
Why?
RNA Splicing
1
1999
14
0.040
Why?
Genetic Therapy
1
1999
7
0.040
Why?
Indans
1
1999
1
0.040
Why?
Thromboxane A2
1
1999
1
0.040
Why?
Immunohistochemistry
1
2019
48
0.040
Why?
DNA Methylation
1
2019
115
0.040
Why?
Phosphorylation
2
2011
22
0.040
Why?
Drug Synergism
1
2018
7
0.040
Why?
Small Molecule Libraries
1
2018
5
0.040
Why?
Dogs
1
2018
17
0.040
Why?
Alkylation
1
1998
1
0.040
Why?
Methylnitrosourea
1
1998
1
0.040
Why?
Mutagens
1
1998
1
0.040
Why?
Trimethylsilyl Compounds
1
1998
1
0.040
Why?
Gene Targeting
1
1998
5
0.040
Why?
Genes, Tumor Suppressor
2
2010
4
0.040
Why?
Dose-Response Relationship, Drug
1
2018
94
0.040
Why?
Imidazoline Receptors
1
2017
1
0.040
Why?
Mice, Mutant Strains
1
2017
7
0.040
Why?
Oxidation-Reduction
1
2017
9
0.040
Why?
Dimethylnitrosamine
1
1997
1
0.040
Why?
Nanoparticles
1
2017
1
0.040
Why?
DNA Primers
2
2011
30
0.040
Why?
Sex Factors
1
1997
68
0.040
Why?
Neoplasm Grading
1
2017
19
0.040
Why?
DNA, Antisense
1
1997
1
0.040
Why?
Neuroectodermal Tumors, Primitive
1
1997
1
0.040
Why?
Ribonucleoproteins
1
1997
2
0.040
Why?
Sarcoma, Ewing
1
1997
7
0.040
Why?
Aged, 80 and over
1
2017
151
0.040
Why?
Tumor Burden
1
2016
3
0.030
Why?
Prognosis
1
2017
211
0.030
Why?
Follow-Up Studies
1
2017
304
0.030
Why?
Glycolysis
1
2013
4
0.030
Why?
Lactic Acid
1
2013
3
0.030
Why?
Extracellular Space
1
2013
5
0.030
Why?
Hydrogen-Ion Concentration
1
2013
19
0.030
Why?
Telomere-Binding Proteins
1
2012
2
0.030
Why?
Interleukin-7
1
2012
2
0.030
Why?
Chromosomal Instability
1
2012
2
0.030
Why?
Cell Differentiation
1
2012
59
0.020
Why?
Cesium Radioisotopes
1
2011
1
0.020
Why?
Th1 Cells
1
2011
1
0.020
Why?
Mice, Congenic
1
2011
2
0.020
Why?
Lymphoid Tissue
1
2011
3
0.020
Why?
CD4-Positive T-Lymphocytes
1
2011
11
0.020
Why?
Th17 Cells
1
2011
5
0.020
Why?
Interleukin-6
1
2011
12
0.020
Why?
Flow Cytometry
1
2011
32
0.020
Why?
Thyroid Gland
1
2011
3
0.020
Why?
Cytokines
1
2011
48
0.020
Why?
Plicamycin
1
2010
1
0.020
Why?
Sp1 Transcription Factor
1
2010
1
0.020
Why?
Cell Growth Processes
1
2010
2
0.020
Why?
Genotype
1
2011
410
0.020
Why?
HCT116 Cells
1
2009
2
0.020
Why?
NIH 3T3 Cells
1
2009
5
0.020
Why?
Mammals
1
2009
4
0.020
Why?
Genetic Predisposition to Disease
1
2010
231
0.020
Why?
Polymorphism, Single Nucleotide
1
2010
348
0.020
Why?
DNA Replication
1
2004
3
0.020
Why?
Phosphoproteins
1
2004
14
0.020
Why?
Gamma Rays
1
2004
1
0.020
Why?
Papilloma
1
2004
1
0.020
Why?
Neoplasms, Squamous Cell
1
2004
1
0.020
Why?
Thymus Gland
1
2004
2
0.020
Why?
Transcriptional Activation
1
2004
9
0.020
Why?
Carcinoma
1
2004
7
0.020
Why?
Skin
1
2004
15
0.020
Why?
Stem Cells
1
2004
29
0.020
Why?
Clone Cells
1
2001
2
0.010
Why?
Chimera
1
2001
4
0.010
Why?
Restriction Mapping
1
2001
6
0.010
Why?
Crosses, Genetic
1
2001
6
0.010
Why?
Recombination, Genetic
1
2001
5
0.010
Why?
Blastocyst
1
2001
4
0.010
Why?
Adenocarcinoma
1
2001
9
0.010
Why?
Exons
1
2001
34
0.010
Why?
Binding, Competitive
1
1999
1
0.010
Why?
RNA, Transfer
1
1999
1
0.010
Why?
Protein Inhibitors of Activated STAT
1
1999
1
0.010
Why?
RNA
1
1999
14
0.010
Why?
Recombinant Proteins
1
1999
48
0.010
Why?
Gene Products, gag
1
1999
1
0.010
Why?
Gene Products, env
1
1999
1
0.010
Why?
5' Untranslated Regions
1
1999
2
0.010
Why?
Cytoplasm
1
1999
7
0.010
Why?
Binding Sites
1
1999
26
0.010
Why?
Protein Engineering
1
1999
3
0.010
Why?
HeLa Cells
1
1999
17
0.010
Why?
Rats, Sprague-Dawley
1
1999
50
0.010
Why?
Molecular Sequence Data
1
1999
71
0.010
Why?
Rabbits
1
1999
5
0.010
Why?
Muscle Contraction
1
1999
3
0.010
Why?
Base Sequence
1
1999
81
0.010
Why?
Platelet Aggregation Inhibitors
1
1999
5
0.010
Why?
Aorta
1
1999
8
0.010
Why?
Heterogeneous-Nuclear Ribonucleoproteins
1
1997
1
0.010
Why?
Proto-Oncogene Protein c-fli-1
1
1997
1
0.010
Why?
Thionucleotides
1
1997
2
0.010
Why?
RNA, Neoplasm
1
1997
4
0.010
Why?
RNA-Binding Protein EWS
1
1997
2
0.010
Why?
Translocation, Genetic
1
1997
4
0.010
Why?
Oncogene Proteins, Fusion
1
1997
8
0.010
Why?
Iwakuma's Networks
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