 Down-Regulation
"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
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| MeSH Number(s) |
G02.111.087.225 G02.149.115.225 G05.355.315.200 G07.690.773.937
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| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 3 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Gong M, Li J, Qin Z, Machado Bressan Wilke MV, Liu Y, Li Q, Liu H, Liang C, Morales-Rosado JA, Cohen ASA, Hughes SS, Sullivan BR, Waddell V, van den Boogaard MH, van Jaarsveld RH, van Binsbergen E, van Gassen KL, Wang T, Hiatt SM, Amaral MD, Kelley WV, Zhao J, Feng W, Ren C, Yu Y, Boczek NJ, Ferber MJ, Lahner C, Elliott S, Ruan Y, Mignot C, Keren B, Xie H, Wang X, Popp B, Zweier C, Piard J, Coubes C, Mau-Them FT, Safraou H, Innes AM, Gauthier J, Michaud JL, Koboldt DC, Sylvie O, Willems M, Tan WH, Cogne B, Rieubland C, Braun D, McLean SD, Platzer K, Zacher P, Oppermann H, Evenepoel L, Blanc P, El Khattabi L, Haque N, Dsouza NR, Zimmermann MT, Urrutia R, Klee EW, Shen Y, Du H, Rappaport L, Liu CM, Chen X. MARK2 variants cause autism spectrum disorder via the downregulation of WNT/?-catenin signaling pathway. Am J Hum Genet. 2024 Nov 07; 111(11):2392-2410.
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Tao F, Soffers J, Hu D, Chen S, Gao X, Zhang Y, Zhao C, Smith SE, Unruh JR, Zhang D, Tsuchiya D, Venkatraman A, Zhao M, Li Z, Qian P, Parmely T, He XC, Washburn M, Florens L, Perry JM, Zeitlinger J, Workman J, Li L. ?-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells. Stem Cell Reports. 2020 09 08; 15(3):662-676.
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Zhang Y, Lickteig AJ, Liu J, Csanaky IL, Klaassen CD. Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice. Toxicol Appl Pharmacol. 2020 09 15; 403:115170.
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Bradley T, Ferrari G, Haynes BF, Margolis DM, Browne EP. Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency. Cell Rep. 2018 10 02; 25(1):107-117.e3.
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Gonzalez VJ, Saligan LN, Fridley BL, Ortiz-Zuazaga H, Aaronson LS. Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study. P R Health Sci J. 2017 12; 36(4):223-231.
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Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF. Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. Am J Surg. 2016 Oct; 212(4):602-608.
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Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9.
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Iyer SV, Parrales A, Begani P, Narkar A, Adhikari AS, Martinez LA, Iwakuma T. Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities. Oncotarget. 2016 Feb 02; 7(5):5401-15.
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Maulik D, De A, Ragolia L, Evans J, Grigoryev D, Lankachandra K, Mundy D, Muscat J, Gerkovich MM, Ye SQ. Down-regulation of placental neuropilin-1 in fetal growth restriction. Am J Obstet Gynecol. 2016 Feb; 214(2):279.e1-279.e9.
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Labreche K, Simeonova I, Kamoun A, Gleize V, Chubb D, Letouz? E, Riazalhosseini Y, Dobbins SE, Elarouci N, Ducray F, de Reyni?s A, Zelenika D, Wardell CP, Frampton M, Saulnier O, Pastinen T, Hallout S, Figarella-Branger D, Dehais C, Idbaih A, Mokhtari K, Delattre JY, Huillard E, Mark Lathrop G, Sanson M, Houlston RS. TCF12 is mutated in anaplastic oligodendroglioma. Nat Commun. 2015 Jun 12; 6:7207.
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