 STAT5 Transcription Factor
"STAT5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
| Descriptor ID |
D050799
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| MeSH Number(s) |
D12.644.360.024.342.500 D12.776.157.057.186.500 D12.776.476.024.421.500 D12.776.930.840.500
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| Concept/Terms |
STAT5 Transcription Factor- STAT5 Transcription Factor
- Factor, STAT5 Transcription
- Transcription Factor, STAT5
- Signal Transducer and Activator of Transcription 5
- STAT5 Protein
STAT5b Transcription Factor- STAT5b Transcription Factor
- Transcription Factor, STAT5b
- STAT5b Protein
- STAT5beta Protein
- Signal Transducer and Activator of Transcription 5B
STAT5a Transcription Factor- STAT5a Transcription Factor
- Transcription Factor, STAT5a
- STAT5alpha Protein
- Signal Transducer and Activator of Transcription 5A
- STAT5a Protein
- Mammary Gland Factor
- Mammary Gland-Specific Nuclear Factor
- Mammary Gland Specific Nuclear Factor
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Below are MeSH descriptors whose meaning is more general than "STAT5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT5 Transcription Factor".
This graph shows the total number of publications written about "STAT5 Transcription Factor" by people in this website by year, and whether "STAT5 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "STAT5 Transcription Factor" by people in Profiles.
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Narayanan P, Man TK, Gerbing RB, Ries R, Stevens AM, Wang YC, Long X, Gamis AS, Cooper T, Meshinchi S, Alonzo TA, Redell MS. Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia. Clin Transl Oncol. 2021 Oct; 23(10):2141-2154.
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Subramaniam D, Angulo P, Ponnurangam S, Dandawate P, Ramamoorthy P, Srinivasan P, Iwakuma T, Weir SJ, Chastain K, Anant S. Suppressing STAT5 signaling affects osteosarcoma growth and stemness. Cell Death Dis. 2020 02 24; 11(2):149.
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Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, M?schen M, Kornblau SM, Farrar MA. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 06; 18(6):694-704.
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Wit JM, de Luca F. Atypical defects resulting in growth hormone insensitivity. Growth Horm IGF Res. 2016 06; 28:57-61.
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Fu Q, McKnight RA, Callaway CW, Yu X, Lane RH, Majnik AV. Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene. FASEB J. 2015 Apr; 29(4):1176-84.
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Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcagic N, Roberson ED, Matthews H, Verbsky JW, Dasu T, Vargas-Hernandez A, Varghese N, McClain KL, Karam LB, Nahmod K, Makedonas G, Mace EM, Sorte HS, Perminow G, Rao VK, O'Connell MP, Price S, Su HC, Butrick M, McElwee J, Hughes JD, Willet J, Swan D, Xu Y, Santibanez-Koref M, Slowik V, Dinwiddie DL, Ciaccio CE, Saunders CJ, Septer S, Kingsmore SF, White AJ, Cant AJ, Hambleton S, Cooper MA. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 2015 Jan 22; 125(4):591-9.
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Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA. IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle. J Immunol. 2012 Jun 15; 188(12):6084-92.
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Kubicky RA, Wu S, Kharitonenkov A, De Luca F. Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May; 153(5):2287-95.
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Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med. 2011 Jun 06; 208(6):1135-49.
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Wu S, Morrison A, Sun H, De Luca F. Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2. J Biol Chem. 2011 Jul 15; 286(28):24726-34.
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