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research overview Dr. Ramsey joined Children’s Mercy in 2023 as the Section Chief of Individualized Therapeutics in the Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation. She is leading the implementation of a pharmacogenomics program that is fully integrated with the electronic health record, and she is developing model-informed decision support for several medications. Before joining Children’s Mercy, Dr. Ramsey was an Associate Professor at Cincinnati Children’s Hospital Medical Center, co-director of the Genetic Pharmacology Service, and co-director of the Clinical Pharmacology Fellowship program. She completed her postdoctoral fellowship in Pharmacogenetics at St. Jude Children’s Research Hospital and received her PhD in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota – Twin Cities. Dr. Ramsey is interested in all aspects of pharmacogenetics, from basic research to implementation in patient care. She has led projects to study pharmacogenetic variants that influence response, toxicity, and dosing of antidepressants, immunosuppressants, and chemotherapy in children. She has authored over 100 peer-reviewed manuscripts, hundreds of abstract presentations, and is extramurally funded, including a National Institutes of Health R01 award.

One or more keywords matched the following items that are connected to Ramsey, Laura

Item TypeName
Concept Alanine Transaminase
Concept Analgesics, Opioid
Concept Antibodies
Concept Antidepressive Agents
Concept Antiemetics
Concept Epitopes
Concept Antigens
Concept Antimetabolites, Antineoplastic
Concept Antineoplastic Agents
Concept Asparaginase
Concept Base Sequence
Concept Binding Sites
Concept Biphenyl Compounds
Concept Carrier Proteins
Concept Catechol O-Methyltransferase
Concept Leucovorin
Concept Codeine
Concept Collagen
Concept Corticosterone
Concept Cytochrome P-450 Enzyme System
Concept Dexamethasone
Concept DNA-Binding Proteins
Concept Dose-Response Relationship, Drug
Concept Drug Administration Schedule
Concept Drug Compounding
Concept Drug Hypersensitivity
Concept Drug Interactions
Concept Drug Labeling
Concept Drug Evaluation, Preclinical
Concept Drug Screening Assays, Antitumor
Concept Drug Synergism
Concept Pharmaceutical Preparations
Concept Exons
Concept Fluoxetine
Concept Glucocorticoids
Concept Immunoglobulins
Concept Immunoglobulin kappa-Chains
Concept Immunoglobulin Light Chains
Concept Immunosuppressive Agents
Concept Ionophores
Concept Lipase
Concept Lipids
Concept Membrane Proteins
Concept Methotrexate
Concept Methyltransferases
Concept Neoplasm Proteins
Concept Nitriles
Concept Nitrophenols
Concept Norepinephrine
Concept Oxycodone
Concept Phorbol Esters
Concept Piperazines
Concept Polyethylene Glycols
Concept Prednisolone
Concept Drug Prescriptions
Concept Protein-Tyrosine Kinases
Concept Proto-Oncogene Proteins
Concept Psychotropic Drugs
Concept gamma-Glutamyl Hydrolase
Concept Pyrazoles
Concept Pyrimidines
Concept Receptors, Antigen, B-Cell
Concept Receptors, Fc
Concept Receptors, Glucocorticoid
Concept Recombinant Proteins
Concept RNA, Messenger
Concept Serotonin
Concept Sulfonamides
Concept Tetrahydrofolates
Concept Thyrotropin
Concept Antipsychotic Agents
Concept Anti-Anxiety Agents
Concept Transcription Factors
Concept Biomarkers, Tumor
Concept Citalopram
Concept Trans-Activators
Concept Fluconazole
Concept Interleukin-7
Concept Fusion Proteins, bcr-abl
Concept Tacrolimus
Concept Program Development
Concept Ondansetron
Concept Receptors, Opioid, mu
Concept Receptors, Kainic Acid
Concept Homeodomain Proteins
Concept Antirheumatic Agents
Concept ATP-Binding Cassette Transporters
Concept Antidepressive Agents, Second-Generation
Concept Cell Cycle Proteins
Concept Antineoplastic Agents, Hormonal
Concept Risperidone
Concept Drug Resistance, Neoplasm
Concept src-Family Kinases
Concept Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept Cytochrome P-450 CYP2D6
Concept Simvastatin
Concept Caspase 1
Concept Sertraline
Concept Receptors, Interleukin-7
Concept Tumor Suppressor Proteins
Concept Organic Anion Transporters
Concept Organic Cation Transport Proteins
Concept Methylenetetrahydrofolate Reductase (NADPH2)
Concept Receptors, G-Protein-Coupled
Concept Receptor, Serotonin, 5-HT2A
Concept Receptor, PAR-2
Concept VDJ Recombinases
Concept raf Kinases
Concept Adaptor Proteins, Signal Transducing
Concept Serotonin Plasma Membrane Transport Proteins
Concept NFATC Transcription Factors
Concept STAT5 Transcription Factor
Concept Interferon Regulatory Factors
Concept Apoptosis Regulatory Proteins
Concept bcl-X Protein
Concept Cytochrome P-450 CYP3A
Concept Ikaros Transcription Factor
Concept NF-kappa B p50 Subunit
Concept Janus Kinase 2
Concept Pre-B Cell Receptors
Concept Drug Dosage Calculations
Concept Bone Morphogenetic Protein 7
Concept Prescription Drugs
Concept Inflammasomes
Concept HLA-DRB1 Chains
Concept Ataxia Telangiectasia Mutated Proteins
Concept Drug-Related Side Effects and Adverse Reactions
Concept Protein Kinase C beta
Concept Cytochrome P-450 CYP2C19 Inhibitors
Concept Cytochrome P-450 CYP2D6 Inhibitors
Concept Cytochrome P-450 CYP2B6
Concept Cytochrome P-450 CYP2C9
Concept Cytochrome P-450 CYP2C19
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.
Academic Article Functional characterization of liver enhancers that regulate drug-associated transporters.
Academic Article The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.
Academic Article Genome-wide study of methotrexate clearance replicates SLCO1B1.
Academic Article Substrain-specific differences in survival and osteonecrosis incidence in a mouse model.
Academic Article Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Academic Article The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Academic Article HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.
Academic Article Effect of premedications in a murine model of asparaginase hypersensitivity.
Academic Article NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Academic Article Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.
Academic Article Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.
Academic Article Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia.
Academic Article Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.
Academic Article Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.
Academic Article Genetics of pleiotropic effects of dexamethasone.
Academic Article Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.
Academic Article Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine.
Academic Article Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Academic Article Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.
Academic Article Interpreting and Implementing Clinical Pharmacogenetic Tests: Perspectives From Service Providers.
Academic Article Gene-Based Dose Optimization in Children.
Academic Article Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia.
Academic Article Cariprazine in Youth with Bipolar and Psychotic Disorders: A Retrospective Chart Review.
Academic Article PharmGKB summary: sertraline pathway, pharmacokinetics.
Academic Article MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase.
Academic Article Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology.
Academic Article Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients.
Academic Article Opportunity for Genotype-Guided Prescribing Among Adult Patients in 11 US Health Systems.
Academic Article Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing.
Academic Article Pediatric Therapeutic Drug Monitoring for Selective Serotonin Reuptake Inhibitors.
Academic Article Development of Competency-based Online Genomic Medicine Training (COGENT).
Academic Article Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients.
Grant Identifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIA

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