NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet. 2015 Jun; 47(6):607-14.
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Adolescent
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Antineoplastic Agents, Hormonal
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Base Sequence
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Carrier Proteins
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Caspase 1
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Child
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Child, Preschool
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DNA Methylation
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Gene Expression Regulation, Leukemic
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HEK293 Cells
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Humans
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Infant
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Infant, Newborn
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Inflammasomes
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Neoplasm Recurrence, Local
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Prednisolone
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Proteolysis
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Receptors, Glucocorticoid
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Transcription, Genetic
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Tumor Cells, Cultured
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Up-Regulation
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