 Asparaginase
"Asparaginase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
| Descriptor ID |
D001215
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| MeSH Number(s) |
D08.811.277.087.116
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| Concept/Terms |
Asparaginase- Asparaginase
- Asparagine Deaminase
- Deaminase, Asparagine
- Colaspase
- Asparaginase II
Erwinase- Erwinase
- Speywood Brand of Asparaginase
- Asparaginase Speywood Brand
- Ispen Brand of Asparaginase
- Asparaginase Ispen Brand
Paronal- Paronal
- Christiaens Brand of Asparaginase
- Asparaginase Christiaens Brand
Crasnitin- Crasnitin
- Bayer Brand of Asparaginase
- Asparaginase Bayer Brand
Kidrolase- Kidrolase
- Sanfer Brand of Asparaginase
- Asparaginase Sanfer Brand
- Leunase
- Bellon Brand of Asparaginase
- Asparaginase Bellon Brand
- Rhône-Poulenc Rorer Brand of Asparaginase
- Rhône Poulenc Rorer Brand of Asparaginase
Elspar- Elspar
- Merck Brand of Asparaginase
- Asparaginase Merck Brand
Asparaginase medac- Asparaginase medac
- medac, Asparaginase
- medac Brand of Asparaginase
- Asparaginase medac Brand
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Below are MeSH descriptors whose meaning is more general than "Asparaginase".
Below are MeSH descriptors whose meaning is more specific than "Asparaginase".
This graph shows the total number of publications written about "Asparaginase" by people in this website by year, and whether "Asparaginase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 1 | 2 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 3 | 1 | 4 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Asparaginase" by people in Profiles.
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Burke MJ, Kostadinov R, Sposto R, Gore L, Kelley SM, Rabik C, Trepel JB, Lee MJ, Yuno A, Lee S, Bhojwani D, Jeha S, Chang BH, Sulis ML, Hermiston ML, Gaynon P, Huynh V, Verma A, Gardner R, Heym KM, Dennis RM, Ziegler DS, Laetsch TW, Oesterheld JE, Dubois SG, Pollard JA, Glade-Bender J, Cooper TM, Kaplan JA, Farooqi MS, Yoo B, Guest E, Wayne AS, Brown PA. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study. Clin Cancer Res. 2020 05 15; 26(10):2297-2307.
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August KJ, Guest EM, Lewing K, Hays JA, Gamis AS. Treatment of children with relapsed and refractory acute lymphoblastic leukemia with mitoxantrone, vincristine, pegaspargase, dexamethasone, and bortezomib. Pediatr Blood Cancer. 2020 03; 67(3):e28062.
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Finch ER, Smith CA, Yang W, Liu Y, Kornegay NM, Panetta JC, Crews KR, Molinelli AR, Cheng C, Pei D, Ramsey LB, Karol SE, Inaba H, Sandlund JT, Metzger M, Evans WE, Jeha S, Pui CH, Relling MV. Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2020 01; 67(1):e28040.
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August KJ, Farooki S, Fulbright JM, August A, Portnoy JM, Pommert L, Burke MJ, Guest EM. Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma. Pediatr Blood Cancer. 2020 01; 67(1):e28021.
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Karol SE, Janke LJ, Panetta JC, Ramsey LB, Cai X, Payton MA, Jenkins DA, Evans WE, Relling MV. Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models. PLoS One. 2019; 14(5):e0216328.
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Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV. Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Clin Pharmacol Ther. 2017 07; 102(1):131-140.
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Liu C, Janke LJ, Kawedia JD, Ramsey LB, Cai X, Mattano LA, Boyd KL, Funk AJ, Relling MV. Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model. PLoS One. 2016; 11(3):e0151433.
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Dekking SA, van der Graaf R, de Vries MC, Bierings MB, van Delden JJ, Kodish E, Lantos JD. Is a New Protocol for Acute Lymphoblastic Leukemia Research or Standard Therapy? Pediatrics. 2015 Sep; 136(3):566-70.
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Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood. 2015 Jul 02; 126(1):69-75.
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Fernandez CA, Smith C, Karol SE, Ramsey LB, Liu C, Pui CH, Jeha S, Evans WE, Finkelman FD, Relling MV. Effect of premedications in a murine model of asparaginase hypersensitivity. J Pharmacol Exp Ther. 2015 Mar; 352(3):541-51.
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