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Leeder, J. Steven

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Item Type	Name
Concept	Cytochrome P-450 Enzyme System
Concept	Cytochrome P-450 CYP1A1
Concept	Cytochrome P-450 CYP1A2
Concept	Cytochrome P-450 CYP2D6
Concept	Cytochrome P-450 CYP2E1
Concept	Cytochrome P-450 CYP3A
Concept	Cytochrome P-450 Enzyme Inhibitors
Concept	Cytochrome P-450 CYP1A2 Inhibitors
Concept	Cytochrome P-450 CYP1B1
Concept	Cytochrome P-450 CYP2A6
Concept	Cytochrome P-450 CYP2D6 Inhibitors
Concept	Cytochrome P-450 CYP3A Inhibitors
Concept	Cytochrome P-450 CYP2C9 Inducers
Concept	Cytochrome P-450 CYP2B6
Concept	Cytochrome P-450 CYP2C9
Concept	Cytochrome P-450 CYP2C19
Academic Article	Pharmacogenetics and pharmacogenomics.
Academic Article	Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Academic Article	Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article	Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation.
Academic Article	Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article	Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article	Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article	Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article	Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article	Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Academic Article	CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.
Academic Article	Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Academic Article	Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article	Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article	Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects.
Academic Article	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article	Variability of CYP3A7 expression in human fetal liver.
Academic Article	Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Academic Article	Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article	CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article	Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article	Biotransformation of fluticasone: in vitro characterization.
Academic Article	Variability of CYP2J2 expression in human fetal tissues.
Academic Article	Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article	Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article	Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article	Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article	Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
Academic Article	Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article	Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article	Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article	Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article	CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article	Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article	The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article	CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article	Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article	Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article	Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article	High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article	CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article	Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article	CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article	Meaningful use and clinical utility of preemptive pharmacogenetic testing: (re)view from a CYP2D6 poor metabolizer.
Academic Article	SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.
Academic Article	Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article	Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article	CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Academic Article	Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Academic Article	Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article	Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.
Academic Article	Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.
Academic Article	Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article	Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article	Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article	Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Academic Article	Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article	The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.
Academic Article	Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article	Cytochrome P450 3A: ontogeny and drug disposition.
Academic Article	Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article	Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	In vitro analysis of metabolic predisposition to drug hypersensitivity reactions.
Academic Article	Aprepitant and fosaprepitant drug interactions: a systematic review.
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article	Anti-cytochrome P450 antibodies in patients with aromatic anticonvulsant-induced hypersensitivity reactions. in Cytochrome P450 Biochemistry, Biophysics and Molecular Biology, Lechner MC, ed
Academic Article	A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Academic Article	Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic acid (SSDA) as a Urinary Biomarker of Cytochrome P450 2D6 (CYP2D6) Activity.
Academic Article	A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Academic Article	Response to "What is the Current Clinical Impact of the CYP2C:TG Haplotype?"

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Cytochrome P 450 Enzyme System