 Gene Amplification
"Gene Amplification" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
| Descriptor ID |
D005784
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| MeSH Number(s) |
G05.355.315.250 G05.355.600.315 G05.365.590.310
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Gene Amplification".
Below are MeSH descriptors whose meaning is more specific than "Gene Amplification".
This graph shows the total number of publications written about "Gene Amplification" by people in this website by year, and whether "Gene Amplification" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Amplification" by people in Profiles.
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Gaedigk A, Ndjountch? L, Divakaran K, Dianne Bradford L, Zineh I, Oberlander TF, Brousseau DC, McCarver DG, Johnson JA, Alander SW, Wayne Riggs K, Steven Leeder J. Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. Clin Pharmacol Ther. 2007 Feb; 81(2):242-51.
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Selvarangan R, Bui U, Limaye AP, Cookson BT. Rapid identification of commonly encountered Candida species directly from blood culture bottles. J Clin Microbiol. 2003 Dec; 41(12):5660-4.
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McArthur CP, Wang Y, Heruth D, Gustafson S. Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. Arch Oral Biol. 2001 Jun; 46(6):545-55.
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Pastinen T, Partanen J, Syv?nen AC. Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation. Clin Chem. 1996 Sep; 42(9):1391-7.
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Curran T, Miller AD, Zokas L, Verma IM. Viral and cellular fos proteins: a comparative analysis. Cell. 1984 Feb; 36(2):259-68.
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