 Cholesterol Side-Chain Cleavage Enzyme
"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
| Descriptor ID |
D002786
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| MeSH Number(s) |
D08.244.453.915.212 D08.811.682.690.708.170.915.212 D12.776.422.220.453.915.212
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| Concept/Terms |
Cholesterol Side-Chain Cleavage Enzyme- Cholesterol Side-Chain Cleavage Enzyme
- Cholesterol Side Chain Cleavage Enzyme
- 20,22-Desmolase
- 20,22 Desmolase
- Cholesterol Desmolase
- Cytochrome P450 11A1
- CYP 11A1
- CYP11A1
- Cytochrome P-450 CYP11A1
- Cytochrome P 450 CYP11A1
- Cytochrome P-450(scc)
- Cytochrome P450scc
- Cholesterol Monooxygenase (Side-Chain-Cleaving)
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Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".
This graph shows the total number of publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in this website by year, and whether "Cholesterol Side-Chain Cleavage Enzyme" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in Profiles.
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King SR, Ginsberg SD, Ishii T, Smith RG, Parker KL, Lamb DJ. The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain. Endocrinology. 2004 Oct; 145(10):4775-80.
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King SR, Manna PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K, Walsh LP, Parker KL, Stocco DM, Smith RG, Lamb DJ. An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci. 2002 Dec 15; 22(24):10613-20.
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Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10939-43.
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