 Cholesterol 7-alpha-Hydroxylase
"Cholesterol 7-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
| Descriptor ID |
D002790
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| MeSH Number(s) |
D08.244.453.915.200 D08.811.682.690.708.170.915.200 D12.776.422.220.453.915.200
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| Concept/Terms |
Cholesterol 7-alpha-Hydroxylase- Cholesterol 7-alpha-Hydroxylase
- Cholesterol 7 alpha Hydroxylase
- Cholesterol 7-alpha-Monooxygenase
- Cholesterol 7 alpha Monooxygenase
- Cholesterol 7alpha-Hydroxylase
- Cholesterol 7alpha Hydroxylase
- Cytochrome P-450 CYP7
- Cytochrome P 450 CYP7
- CYP 7
- CYP 7A
- CYP7
- CYP7A
- Cytochrome P450 7
- Cholesterol-7-Hydroxylase
- Cholesterol 7 Hydroxylase
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Below are MeSH descriptors whose meaning is more general than "Cholesterol 7-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol 7-alpha-Hydroxylase".
This graph shows the total number of publications written about "Cholesterol 7-alpha-Hydroxylase" by people in this website by year, and whether "Cholesterol 7-alpha-Hydroxylase" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cholesterol 7-alpha-Hydroxylase" by people in Profiles.
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Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Activation of PPARa decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicol Appl Pharmacol. 2018 01 01; 338:112-123.
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Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD. Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicol Sci. 2016 06; 151(2):403-18.
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Zinkhan EK, Chin JR, Zalla JM, Yu B, Numpang B, Yu X, Jiang C, Callaway CW, McKnight RA, Joss-Moore L, Lane RH. Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats. Pediatr Res. 2014 Nov; 76(5):432-40.
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Fu ZD, Csanaky IL, Klaassen CD. Gender-divergent profile of bile acid homeostasis during aging of mice. PLoS One. 2012; 7(3):e32551.
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