D018160Chemicals & DrugsD12.776.826350.995736Receptors, Cytoplasmic and Nuclearcmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson15316010Vyhlidal CA, Rogan PK, Leeder JSThe Journal of biological chemistryVyhlidal CA, Rogan PK, Leeder JS. Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation. J Biol Chem. 2004 Nov 05; 279(45):46779-86.J Biol Chem2004-08-16T00:00:002004Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.16243958Vyhlidal CA, Gaedigk R, Leeder JSDrug metabolism and disposition: the biological fate of chemicalsVyhlidal CA, Gaedigk R, Leeder JS. Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. Drug Metab Dispos. 2006 Jan; 34(1):131-7.Drug Metab Dispos2005-10-21T00:00:002005Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.18076137Bi C, Leeder JS, Vyhlidal CAMolecular pharmaceuticsBi C, Leeder JS, Vyhlidal CA. A comparative study on computational two-block motif detection: algorithms and applications. Mol Pharm. 2008 Jan-Feb; 5(1):3-16.Mol Pharm2007-12-13T00:00:002007A comparative study on computational two-block motif detection: algorithms and applications.24389307Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li XGastroenterologyKazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X. Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1a-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology. 2014 Apr; 146(4):1006-16.Gastroenterology2013-12-31T00:00:002013Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1a-FXR signaling and alters systemic bile acid homeostasis.26984780Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CDToxicological sciences : an official journal of the Society of ToxicologyLickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD. Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicol Sci. 2016 06; 151(2):403-18.Toxicol Sci2016-03-16T00:00:002016Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.0.6139930.008726463research area of0.5733690.03505538subject area for1ProfessorPediatricsResearchClinicalMD, PhDMarkClementsMark A. Clements39.08346750000000-94.5771129000000023Clements, MarkEndocrinologist and Medical Director, Pediatric Clinical Research UnitPharmD, PhDJ. StevenLeederJ. Steven Leeder39.08346750000000-94.5771129000000034Leeder, J. Steven0000-0001-6688-0504Deputy Director, Children's Research InstituteChildren's Mercy Kansas CityMD, MSRobertLaneRobert H. Lane0.000000000000000.00000000000000179Lane, RobertExecutive Vice President/Physician-in-Chieftrue1Deputy Director, Children's Research InstituteDeputy Director, Children's Research Institutetrue1Endocrinologist and Medical Director, Pediatric Clinical Research UnitEndocrinologist and Medical Director, Pediatric Clinical Research Unittrue1Executive Vice President/Physician-in-ChiefExecutive Vice President/Physician-in-Chief