 Kernicterus
"Kernicterus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Descriptor ID |
D007647
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| MeSH Number(s) |
C10.228.140.163.480 C15.378.295.502 C16.614.304.502 C18.452.132.480 C20.306.502 C23.550.429.750
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| Concept/Terms |
Kernicterus- Kernicterus
- Encephalopathy, Bilirubin
- Bilirubin Encephalopathy
- Bilirubin Encephalopathies
- Encephalopathies, Bilirubin
- Hyperbilirubinemic Encephalopathy
- Encephalopathies, Hyperbilirubinemic
- Hyperbilirubinemic Encephalopathies
- Encephalopathy, Hyperbilirubinemic
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Below are MeSH descriptors whose meaning is more general than "Kernicterus".
- Diseases [C]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Kernicterus [C10.228.140.163.480]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Erythroblastosis, Fetal [C15.378.295]
- Kernicterus [C15.378.295.502]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Infant, Newborn, Diseases [C16.614]
- Erythroblastosis, Fetal [C16.614.304]
- Kernicterus [C16.614.304.502]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Kernicterus [C18.452.132.480]
- Immune System Diseases [C20]
- Erythroblastosis, Fetal [C20.306]
- Kernicterus [C20.306.502]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Hyperbilirubinemia [C23.550.429]
- Kernicterus [C23.550.429.750]
Below are MeSH descriptors whose meaning is more specific than "Kernicterus".
This graph shows the total number of publications written about "Kernicterus" by people in this website by year, and whether "Kernicterus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Kernicterus" by people in Profiles.
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Gelineau-Morel R, Usman F, Shehu S, Yeh HW, Suwaid MA, Abdulsalam M, Jibril Y, Satrom KM, Shapiro SM, Zinkus TP, Head HW, Slusher TM, Le Pichon JB, Farouk ZL. Predictive and diagnostic measures for kernicterus spectrum disorder: a prospective cohort study. Pediatr Res. 2024 Jan; 95(1):285-292.
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Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA. MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus. Cell Transplant. 2022 Jan-Dec; 31:9636897221101116.
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Dasari VR, Shapiro SM, Yeh HW, Gelineau-Morel R. Kernicterus Spectrum Disorders Diagnostic Toolkit: validation using retrospective chart review. Pediatr Res. 2022 03; 91(4):862-866.
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Riordan SM, Shapiro SM. Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease. Pediatr Res. 2020 01; 87(2):327-331.
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Shapiro SM, Riordan SM. Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders. Pediatr Res. 2020 01; 87(2):332-337.
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Riordan SM, Gazzin S. Where do we stand in the field of neonatal jaundice? Commentary on the 2017 J. Donald Ostrow Trieste Yellow Retreat. Pediatr Res. 2018 06; 83(6):1090-1092.
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Le Pichon JB, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Curr Pediatr Rev. 2017; 13(3):199-209.
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