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Jean-Baptiste Le Pichon, MD, PhD, FAAP

TitleDirector, Child Neurology Residency Program
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-8666-1632 Additional info
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    Other Positions
    TitlePhysician
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleClinical Assistant Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Baylor College of Medicine, Houston, TXMD
    Baylor College of Medicine, Houston, TXPhD
    Texas Children's Hospital, Baylor College of Medicine, Houston, TXResidencyChild Neurology
    Texas Children's Hospital, Baylor College of Medicine, Houston, TXFellowshipClinical Neurophysiology Research

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Le Pichon's research interests are broad but currently focus in two general areas of child neurology. The first area is concerned with bilirubin metabolism and toxicity in the infant. This work has resulted from a close collaboration with Dr. Steven Shapiro. Acute bilirubin encephalopathy offers an ideal disease model to study a unique form of choreoathetoid cerebral palsy in that the initial insult and its subsequent consequences are fairly well understood and affect relatively few and constant brain regions. Furthermore, while the disease is relatively well controlled in developed countries (with an incidence comparable to many rare genetic disorders), it remains a major cause of morbidity and mortality in low and middle income countries.

    Dr. Le Pichon also has a strong interest in developing fair and equitable modes of delivering medical care. This has been the force behind a major effort at improving the care of children and youth with epilepsy in underserved and rural areas.
    Collapse research activities and funding
    H98MC33239     (J.B. Le Pichon & Ahmed Abdelmoity)Sep 1, 2019 - Aug 31, 2023
    HRSA
    Reaching out for Epilepsy in Adolescents and Children through Telemedicine (REACT)
    Role Description: This project is a quality improvement project designed to create a medical home for children and youth with epilepsy in the State of Kansas. To achieve this goal the projects combines telemedicine and improved education for primary care physicians, patients and their families as well as improved detection and treatment of mental health issues common to this patient population and improved transition of care when the children reach adulthood.
    Role: Co-Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Paul MS, Michener SL, Pan H, Chan H, Pfliger JM, Rosenfeld JA, Lerma VC, Tran A, Longley MA, Lewis RA, Weisz-Hubshman M, Bekheirnia MR, Bekheirnia N, Massingham L, Zech M, Wagner M, Engels H, Cremer K, Mangold E, Peters S, Trautmann J, Perne C, Mester JL, Guillen Sacoto MJ, Person R, McDonnell PP, Cohen SR, Lusk L, Cohen ASA, Le Pichon JB, Pastinen T, Zhou D, Engleman K, Racine C, Faivre L, Moutton S, Denomm?-Pichon AS, Koh HY, Poduri A, Bolton J, Knopp C, Julia Suh DS, Maier A, Toosi MB, Karimiani EG, Maroofian R, Schaefer GB, Ramakumaran V, Vasudevan P, Banos-Pinero B, Pagnamenta AT, Prasad C, Osmond M, Schuhmann S, Vasileiou G, Russ-Hall S, Scheffer IE, Carvill GL, Mefford H, Bacino CA, Lee BH, Chao ??? HT. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3. Am J Hum Genet. 2024 Jun 06; 111(6):1239. PMID: 38723631.
      View in: PubMed
    2. Paul MS, Michener SL, Pan H, Chan H, Pfliger JM, Rosenfeld JA, Lerma VC, Tran A, Longley MA, Lewis RA, Weisz-Hubshman M, Bekheirnia MR, Bekheirnia N, Massingham L, Zech M, Wagner M, Engels H, Cremer K, Mangold E, Peters S, Trautmann J, Perne C, Mester JL, Guillen Sacoto MJ, Person R, McDonnell PP, Cohen SR, Lusk L, Cohen ASA, Le Pichon JB, Pastinen T, Zhou D, Engleman K, Racine C, Faivre L, Moutton S, Denomm?-Pichon AS, Koh HY, Poduri A, Bolton J, Knopp C, Julia Suh DS, Maier A, Toosi MB, Karimiani EG, Maroofian R, Schaefer GB, Ramakumaran V, Vasudevan P, Banos-Pinero B, Pagnamenta AT, Prasad C, Osmond M, Schuhmann S, Vasileiou G, Russ-Hall S, Scheffer IE, Carvill GL, Mefford H, Bacino CA, Lee BH, Chao HT. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3. Am J Hum Genet. 2024 Apr 04; 111(4):805. PMID: 38508193.
      View in: PubMed
    3. Paul MS, Michener SL, Pan H, Chan H, Pfliger JM, Rosenfeld JA, Lerma VC, Tran A, Longley MA, Lewis RA, Weisz-Hubshman M, Bekheirnia MR, Bekheirnia N, Massingham L, Zech M, Wagner M, Engels H, Cremer K, Mangold E, Peters S, Trautmann J, Mester JL, Guillen Sacoto MJ, Person R, McDonnell PP, Cohen SR, Lusk L, Cohen ASA, Le Pichon JB, Pastinen T, Zhou D, Engleman K, Racine C, Faivre L, Moutton S, Denomm?-Pichon AS, Koh HY, Poduri A, Bolton J, Knopp C, Julia Suh DS, Maier A, Toosi MB, Karimiani EG, Maroofian R, Schaefer GB, Ramakumaran V, Vasudevan P, Prasad C, Osmond M, Schuhmann S, Vasileiou G, Russ-Hall S, Scheffer IE, Carvill GL, Mefford H, Bacino CA, Lee BH, Chao HT. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3. Am J Hum Genet. 2024 01 04; 111(1):96-118. PMID: 38181735.
      View in: PubMed
    4. Gelineau-Morel R, Usman F, Shehu S, Yeh HW, Suwaid MA, Abdulsalam M, Jibril Y, Satrom KM, Shapiro SM, Zinkus TP, Head HW, Slusher TM, Le Pichon JB, Farouk ZL. Predictive and diagnostic measures for kernicterus spectrum disorder: a prospective cohort study. Pediatr Res. 2024 Jan; 95(1):285-292. PMID: 37689774.
      View in: PubMed
    5. Le Pichon JB, Horton S, Abdelmoity O, Hoffman MA, Cramer E, Kishk N, Hamada S, Abdelmoity A. The use of virtual tools in narrowing the impact of health disparities in neurology. Front Pediatr. 2022; 10:1028833. PMID: 36313873.
      View in: PubMed
    6. Cohen ASA, Farrow EG, Abdelmoity AT, Alaimo JT, Amudhavalli SM, Anderson JT, Bansal L, Bartik L, Baybayan P, Belden B, Berrios CD, Biswell RL, Buczkowicz P, Buske O, Chakraborty S, Cheung WA, Coffman KA, Cooper AM, Cross LA, Curran T, Dang TTT, Elfrink MM, Engleman KL, Fecske ED, Fieser C, Fitzgerald K, Fleming EA, Gadea RN, Gannon JL, Gelineau-Morel RN, Gibson M, Goldstein J, Grundberg E, Halpin K, Harvey BS, Heese BA, Hein W, Herd SM, Hughes SS, Ilyas M, Jacobson J, Jenkins JL, Jiang S, Johnston JJ, Keeler K, Korlach J, Kussmann J, Lambert C, Lawson C, Le Pichon JB, Leeder JS, Little VC, Louiselle DA, Lypka M, McDonald BD, Miller N, Modrcin A, Nair A, Neal SH, Oermann CM, Pacicca DM, Pawar K, Posey NL, Price N, Puckett LMB, Quezada JF, Raje N, Rowell WJ, Rush ET, Sampath V, Saunders CJ, Schwager C, Schwend RM, Shaffer E, Smail C, Soden S, Strenk ME, Sullivan BR, Sweeney BR, Tam-Williams JB, Walter AM, Welsh H, Wenger AM, Willig LK, Yan Y, Younger ST, Zhou D, Zion TN, Thiffault I, Pastinen T. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genet Med. 2022 06; 24(6):1336-1348. PMID: 35305867.
      View in: PubMed
    7. Sharma S, Repnikova E, Noel-MacDonnell JR, LePichon JB. Diagnostic yield of genetic testing in 324 infants with hypotonia. Clin Genet. 2021 12; 100(6):752-757. PMID: 34480364.
      View in: PubMed
    8. Abdelmoity SA, Abdelmoity AA, Riordan SM, Kaufman C, Le Pichon JB, Abdelmoity A. The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome. Seizure. 2021 Mar; 86:168-174. PMID: 33626436.
      View in: PubMed
    9. Abdelmoity AT, Le Pichon JB, Abdelmoity SA, Sherman AK, Hall AS, Abdelmoity AT. Combined use of the ketogenic diet and vagus nerve stimulation in pediatric drug-resistant epilepsy. Epilepsia Open. 2021 03; 6(1):112-119. PMID: 33681654.
      View in: PubMed
    10. Gali K, Joshi S, Hueneke S, Katzenbach A, Radecki L, Calabrese T, Fletcher L, Trandafir C, Wilson C, Goyal M, Wusthoff CJ, Le Pichon JB, Corvalan R, Golson A, Hardy J, Smith M, Cook E, Bonkowsky JL. Barriers, access and management of paediatric epilepsy with telehealth. J Telemed Telecare. 2022 Apr; 28(3):213-223. PMID: 33183129.
      View in: PubMed
    11. Cudkowicz M, Chase MK, Coffey CS, Ecklund DJ, Thornell BJ, Lungu C, Mahoney K, Gutmann L, Shefner JM, Staley KJ, Bosch M, Foster E, Long JD, Bayman EO, Torner J, Yankey J, Peters R, Huff T, Conwit RA, Shinnar S, Patch D, Darras BT, Ellis A, Packer RJ, Marder KS, Chiriboga CA, Henchcliffe C, Moran JA, Nikolov B, Factor SA, Seeley C, Greenberg SM, Amato AA, DeGregorio S, Simuni T, Ward T, Kissel JT, Kolb SJ, Bartlett A, Quinn JF, Keith K, Levine SR, Gilles N, Coyle PK, Lamb J, Wolfe GI, Crumlish A, Mejico L, Iqbal MM, Bowen JD, Tongco C, Nabors LB, Bashir K, Benge M, McDonald CM, Henricson EK, Oskarsson B, Dobkin BH, Canamar C, Glauser TA, Woo D, Molloy A, Clark P, Vollmer TL, Stein AJ, Barohn RJ, Dimachkie MM, Le Pichon JB, Benatar MG, Steele J, Wechsler L, Clemens PR, Amity C, Holloway RG, Annis C, Goldberg MP, Andersen M, Iannaccone ST, Smith AG, Singleton JR, Doudova M, Haley EC, Quigg MS, Lowenhaupt S, Malow BA, Adkins K, Clifford DB, Teshome MA, Connolly N. Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials. JAMA Neurol. 2020 06 01; 77(6):755-763. PMID: 32202612.
      View in: PubMed
    12. Scher MS, Breningstall G, Gilbert D, Jordan L, Khakoo Y, LePichon JB. The 2018 Pediatric Neurology Trainee Publication Award. Pediatr Neurol. 2019 12; 101:1. PMID: 31623938.
      View in: PubMed
    13. Gelineau-Morel RN, Zinkus TP, Le Pichon JB. Pediatric Head Trauma: A Review and Update. Pediatr Rev. 2019 Sep; 40(9):468-481. PMID: 31477589.
      View in: PubMed
    14. Ferreira JA, Le Pichon JB, Abdelmoity AT, Dilley D, Dedeken P, Daniels T, Byrnes W. Safety and tolerability of adjunctive lacosamide in a pediatric population with focal seizures - An open-label trial. Seizure. 2019 Oct; 71:166-173. PMID: 31374487.
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    15. Le Pichon JB, Thompson L, Gustafson M, Abdelmoity A. Initiating the ketogenic diet in infants with treatment refractory epilepsy while maintaining a breast milk diet. Seizure. 2019 Jul; 69:41-43. PMID: 30959424.
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    16. Scher MS, Breningstall G, Gilbert D, Jordan L, Khakoo Y, LePichon JB. The 2017 Pediatric Neurology Training Publication Award. Pediatr Neurol. 2018 09; 86:4. PMID: 30390955.
      View in: PubMed
    17. Gbadero DA, Adegbite EO, LePichon JB, Slusher TM. Case Presentation of Anti-NMDA Receptor Encephalitis in a 4-Year-Old Boy. J Trop Pediatr. 2018 Aug 01; 64(4):352-354. PMID: 29040795.
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    18. Scher MS, Breningstall G, Gilbert DL, Jordan L, Khakoo Y, LePichon JB. Editorial: The 2016 Pediatric Neurology Trainee Publication Award. Pediatr Neurol. 2017 10; 75:3. PMID: 28826612.
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    19. Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA. GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis. 2017 Oct; 106:181-190. PMID: 28688853.
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    20. Allison T, Roncero I, Forsyth R, Coffman K, Pichon JL. Brown-Vialetto-Van Laere Syndrome as a Mimic of Neuroimmune Disorders: 3 Cases From the Clinic and Review of the Literature. J Child Neurol. 2017 05; 32(6):528-532. PMID: 28116953.
      View in: PubMed
    21. Le Pichon JB, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Curr Pediatr Rev. 2017; 13(3):199-209. PMID: 28814249.
      View in: PubMed
    22. Flex E, Niceta M, Cecchetti S, Thiffault I, Au MG, Capuano A, Piermarini E, Ivanova AA, Francis JW, Chillemi G, Chandramouli B, Carpentieri G, Haaxma CA, Ciolfi A, Pizzi S, Douglas GV, Levine K, Sferra A, Dentici ML, Pfundt RR, Le Pichon JB, Farrow E, Baas F, Piemonte F, Dallapiccola B, Graham JM, Saunders CJ, Bertini E, Kahn RA, Koolen DA, Tartaglia M. Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy. Am J Hum Genet. 2016 Oct 06; 99(4):962-973. PMID: 27666370.
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    23. Riordan SM, Bittel DC, Le Pichon JB, Gazzin S, Tiribelli C, Watchko JF, Wennberg RP, Shapiro SM. A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy. Front Neurosci. 2016; 10:376. PMID: 27587993.
      View in: PubMed
    24. LePichon JB, Saunders CJ, Soden SE. The Future of Next-Generation Sequencing in Neurology. JAMA Neurol. 2015 Sep; 72(9):971-2. PMID: 26148113.
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    25. Saunders CJ, Moon SH, Liu X, Thiffault I, Coffman K, LePichon JB, Taboada E, Smith LD, Farrow EG, Miller N, Gibson M, Patterson M, Kingsmore SF, Gross RW. Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A2 ? recapitulate the mitochondriopathy of the homologous null mouse. Hum Mutat. 2015 Mar; 36(3):301-6. PMID: 25512002.
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    26. Stanford JA, Shuler JM, Fowler SC, Stanford KG, Ma D, Bittel DC, Le Pichon JB, Shapiro SM. Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. Pediatr Res. 2015 Mar; 77(3):434-9. PMID: 25518009.
      View in: PubMed
    27. Soden SE, Saunders CJ, Willig LK, Farrow EG, Smith LD, Petrikin JE, LePichon JB, Miller NA, Thiffault I, Dinwiddie DL, Twist G, Noll A, Heese BA, Zellmer L, Atherton AM, Abdelmoity AT, Safina N, Nyp SS, Zuccarelli B, Larson IA, Modrcin A, Herd S, Creed M, Ye Z, Yuan X, Brodsky RA, Kingsmore SF. Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders. Sci Transl Med. 2014 Dec 03; 6(265):265ra168. PMID: 25473036.
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    28. Batterson JR, Sullivant S, Le Pichon JB, Kleinsorge C, Price S, Andrews S. A refresher on Tourette syndrome. Mo Med. 2014 May-Jun; 111(3):202-6. PMID: 25011341.
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    29. Dlugos D, Shinnar S, Cnaan A, Hu F, Mosh? S, Mizrahi E, Masur D, Sogawa Y, Le Pichon JB, Levine C, Hirtz D, Clark P, Adamson PC, Glauser T. Pretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome. Neurology. 2013 Jul 09; 81(2):150-6. PMID: 23719147.
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    30. Le Pichon JB, Yu S, Kibiryeva N, Graf WD, Bittel DC. Genome-wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome. Eur J Hum Genet. 2013 Oct; 21(10):1093-9. PMID: 23361223.
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    31. Abdelmoity AT, LePichon JB, Nyp SS, Soden SE, Daniel CA, Yu S. 15q11.2 proximal imbalances associated with a diverse array of neuropsychiatric disorders and mild dysmorphic features. J Dev Behav Pediatr. 2012 Sep; 33(7):570-6. PMID: 22922608.
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    32. Lepichon JB, Bittel DC, Graf WD, Yu S. A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes. Am J Med Genet A. 2010 May; 152A(5):1300-4. PMID: 20425840.
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    33. Graf WD, Le Pichon JB, Bittel DC, Abdelmoity AT, Yu S. Practice parameter: evaluation of the child with microcephaly (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2010 Mar 30; 74(13):1080-1; author reply 1081. PMID: 20350984.
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    34. Mansourati J, Forneiro I, Genet L, Le Pichon J, Blanc JJ. [Regression of dilated cardiomyopathy in a chronic alcoholic patient after abstinence from alcohol]. Arch Mal Coeur Vaiss. 1990 Nov; 83(12):1849-52; discussion 1853. PMID: 2125195.
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    35. Lennard-Jones JE. Sulphasalazine in asymptomatic Crohn's disease. A multicentre trial. Gut. 1977 Jan; 18(1):69-72. PMID: 14057.
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    36. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
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    37. Sinelnikova EM, Dvoretskova TV, Kagan ZS. [Intermediate plateaux in kinetics of the reaction catalyzed by biodegradative L-threonine dehydratase from Escherichia coli]. Biokhimiia. 1975 May-Jun; 40(3):645-51. PMID: 1111.
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