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Jay Vivian, PhD

TitleDirector, Rare Disease Model Research Program
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-5375-5974 Additional info
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    Other Positions
    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Texas MD Anderson Cancer Center, Houston, TXPhD1999Genes and Development
    University of North Carolina, Chapel Hill, NCPostdoctoral2004Developmental Genetics

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Vivian's research uses the mouse and pluripotent stem cells as genetic models of disease, to understand the basis of various disorders and for therapeutic discovery. These efforts leverage expertise in stem cell biology, mouse experimental genetics, molecular biology, genetic engineering, and developmental biology. A major focus of his lab involves the development and analysis of animal and pluripotent stem cell models of rare pediatric congenital disorders, using the genetic data mapped by human genetics studies focused on pediatric neurological disorders. These collaborative translational efforts make substantial use of genome editing to engineer genetically modified mice and patient-specific induced pluripotent stem cells for therapeutic discovery.
    Collapse research activities and funding
    P30CA168524     (JENSEN, ROY A.)Jul 11, 2012 - Jun 30, 2022
    NIH
    Cancer Center Support Grant
    Role: Co-Investigator
    R01HD101319     (PAUL, SOUMEN)Apr 1, 2020 - Mar 31, 2025
    NIH
    Hippo Signaling Effector and Placentation
    Role: Co-Investigator
    MDBR-21-109-TBCK     (Vivian, Jay)Feb 1, 2021 - Jan 31, 2022
    Orphan Disease Center
    Platforms for the identification and validation of candidate small molecule treatments for TBCK syndrome
    Role Description: Major Goals of this study are to develop a cell-based platform using engineered inidcued pluripotent stem cells for assessment of autophagy for use in a pilot-level screen of FDA approved and bioactive small molecule compound library for potential therapies for TBCK Syndrome
    Role: PI
    -     (Vivian, Jay)Jun 14, 2021 - Aug 1, 2023
    Mercy Research Partners
    A novel drug screen for therapies for Vici Syndrome
    Role Description: The goals of this project are to develop a robust screen for small molecules that influence autophagy, using a novel engineered induced pluripotent stem cell-based screening strategy, using differentiated patient-derived iPS cells and their validation in genetically engineered mouse models of Vici Syndrome.
    Role: PI
    UL1 TR002366     (Vivian, Jay)Jul 1, 2021 - Jun 30, 2022
    Frontiers CTSA/NIH-NCATS
    A Cell-Based Platform for Screening for Therapeutics for Vici Syndrome and Other Diseases of Autophagy
    Role Description: The aims of this project are to perform a comprehensive secondary analysis of compounds identified in a cell-based screen for modulators of autophagy in an engineered induced pluripotent stem cell model of Vici Syndrome.
    Role: PI

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Iqbal K, Dominguez EM, Nixon B, Moreno-Irusta A, Crnkovich B, Scott RL, Vu HTH, Tuteja G, Vivian JL, Soares MJ. Conditionally mutant animal model for investigating the invasive trophoblast cell lineage. Development. 2024 Jan 15; 151(2). PMID: 38112206.
      View in: PubMed
    2. Vivian JL, Pence L. Genetic considerations for sourcing research animals. Lab Anim (NY). 2023 09; 52(9):193-194. PMID: 37644301.
      View in: PubMed
    3. Anamthathmakula P, Shallie PD, Nayak N, Dhal S, Vivian JL, Mor G, Soares MJ, Nayak NR. Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSAmT/mG Transgenic Mice. Cells. 2023 08 18; 12(16). PMID: 37626906.
      View in: PubMed
    4. Flannagan K, Stopperan JA, Hauger BM, Troutwine BR, Lysaker CR, Strope TA, Csikos Drummond V, Gilmore CA, Swerdlow NA, Draper JM, Gouvion CM, Vivian JL, Haeri M, Swerdlow RH, Wilkins HM. Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer's disease. Front Mol Neurosci. 2023; 16:1201015. PMID: 37614699.
      View in: PubMed
    5. Iqbal K, Nixon B, Crnkovich B, Dominguez EM, Moreno-Irusta A, Scott RL, Vu HTH, Tuteja G, Vivian JL, Soares MJ. CONDITIONALLY MUTANT ANIMAL MODEL FOR INVESTIGATING THE INVASIVE TROPHOBLAST CELL LINEAGE. bioRxiv. 2023 Aug 05. PMID: 37577576.
      View in: PubMed
    6. Welch DR, Larson MA, Vivian CJ, Vivian JL. Generating Mitochondrial-Nuclear Exchange (MNX) Mice to Identify Mitochondrial Determinants of Cancer Metastasis. Methods Mol Biol. 2023; 2660:43-59. PMID: 37191789.
      View in: PubMed
    7. Parnell SC, Raman A, Zhang Y, Daniel EA, Dai Y, Khanna A, Reif GA, Vivian JL, Fields TA, Wallace DP. Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease. Kidney Int. 2022 11; 102(5):1103-1114. PMID: 35760151.
      View in: PubMed
    8. Feng Y, Borosha S, Ratri A, Lee EB, Wang H, Fields TA, Kinsey WH, Vivian JL, Rumi MAK, Fields PE. DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin. Int J Mol Sci. 2022 May 05; 23(9). PMID: 35563527.
      View in: PubMed
    9. Borosha S, Ratri A, Ghosh S, Malcom CA, Chakravarthi VP, Vivian JL, Fields TA, Rumi MAK, Fields PE. DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts. Front Genet. 2022; 13:828086. PMID: 35401699.
      View in: PubMed
    10. Malcom CA, Ratri A, Piasecka-Srader J, Borosha S, Chakravarthi VP, Alvarez NS, Vivian JL, Fields TA, Karim Rumi MA, Fields PE. Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity. Front Cell Dev Biol. 2021; 9:813503. PMID: 35111761.
      View in: PubMed
    11. Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA. MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus. Cell Transplant. 2022 Jan-Dec; 31:9636897221101116. PMID: 35596532.
      View in: PubMed
    12. Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ. ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649217.
      View in: PubMed
    13. Wang W, Allard BA, Pottorf TS, Wang HH, Vivian JL, Tran PV. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. FASEB J. 2020 05; 34(5):6369-6381. PMID: 32167205.
      View in: PubMed
    14. Larson MA, Gibson KA, Vivian JL. In Vivo Validation of CRISPR Reagents in Preimplantation Mouse Embryos. Methods Mol Biol. 2020; 2066:47-57. PMID: 31512206.
      View in: PubMed
    15. Draper JM, Vivian JL. Reprogramming of Primary Human Cells to Induced Pluripotent Stem Cells Using Sendai Virus. Methods Mol Biol. 2020; 2066:217-234. PMID: 31512220.
      View in: PubMed
    16. Nteeba J, Kubota K, Wang W, Zhu H, Vivian J, Dai G, Soares M. Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis. J Endocrinol. 2019 Feb 01. PMID: 30798322.
      View in: PubMed
    17. Raman A, Parnell SC, Zhang Y, Reif GA, Dai Y, Khanna A, Daniel E, White C, Vivian JL, Wallace DP. Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease. Am J Physiol Renal Physiol. 2018 12 01; 315(6):F1695-F1707. PMID: 30332313.
      View in: PubMed
    18. Yang FC, Draper J, Smith PG, Vivian JL, Shapiro SM, Stanford JA. Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplant. 2018 04; 27(4):654-665. PMID: 29845869.
      View in: PubMed
    19. Rumi MAK, Singh P, Roby KF, Zhao X, Iqbal K, Ratri A, Lei T, Cui W, Borosha S, Dhakal P, Kubota K, Chakraborty D, Vivian JL, Wolfe MW, Soares MJ. Defining the Role of Estrogen Receptor ? in the Regulation of Female Fertility. Endocrinology. 2017 07 01; 158(7):2330-2343. PMID: 28520870.
      View in: PubMed
    20. Bu P, Yagi S, Shiota K, Alam SMK, Vivian JL, Wolfe MW, Rumi MAK, Chakraborty D, Kubota K, Dhakal P, Soares MJ. Origin of a rapidly evolving homeostatic control system programming testis function. J Endocrinol. 2017 Aug; 234(2):217-232. PMID: 28576872.
      View in: PubMed
    21. Baxter AL, Vivian JL, Hagelstrom RT, Hossain W, Golden WL, Wassman ER, Vanzo RJ, Butler MG. A Novel Partial Duplication of ZEB2 and Review of ZEB2 Involvement in Mowat-Wilson Syndrome. Mol Syndromol. 2017 Jun; 8(4):211-218. PMID: 28690488.
      View in: PubMed
    22. Yang FC, Riordan SM, Winter M, Gan L, Smith PG, Vivian JL, Shapiro SM, Stanford JA. Fate of Neural Progenitor Cells Transplanted Into Jaundiced and Nonjaundiced Rat Brains. Cell Transplant. 2017 04 13; 26(4):605-611. PMID: 28155818.
      View in: PubMed
    23. Kesterson RA, Johnson LW, Lambert LJ, Vivian JL, Welch DR, Ballinger SW. Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer. Bio Protoc. 2016 Oct 20; 6(20). PMID: 27840835.
      View in: PubMed
    24. Soares MJ, Vivian JL. Tipping the balance toward trophoblast development. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5144-6. PMID: 27118838.
      View in: PubMed
    25. Kubota K, Cui W, Dhakal P, Wolfe MW, Rumi MA, Vivian JL, Roby KF, Soares MJ. Rethinking progesterone regulation of female reproductive cyclicity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4212-7. PMID: 27035990.
      View in: PubMed
    26. Bu P, Alam SM, Dhakal P, Vivian JL, Soares MJ. A Prolactin Family Paralog Regulates Placental Adaptations to a Physiological Stressor. Biol Reprod. 2016 05; 94(5):107. PMID: 26985002.
      View in: PubMed
    27. Renaud SJ, Chakraborty D, Mason CW, Rumi MA, Vivian JL, Soares MJ. OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6175-84. PMID: 26504231.
      View in: PubMed
    28. Lakatos D, Travis ED, Pierson KE, Vivian JL, Czirok A. Autocrine FGF feedback can establish distinct states of Nanog expression in pluripotent stem cells: a computational analysis. BMC Syst Biol. 2014 Sep 27; 8:112. PMID: 25267505.
      View in: PubMed
    29. Rumi MA, Dhakal P, Kubota K, Chakraborty D, Lei T, Larson MA, Wolfe MW, Roby KF, Vivian JL, Soares MJ. Generation of Esr1-knockout rats using zinc finger nuclease-mediated genome editing. Endocrinology. 2014 May; 155(5):1991-9. PMID: 24506075.
      View in: PubMed
    30. Galvin-Burgess KE, Travis ED, Pierson KE, Vivian JL. TGF-?-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium. Stem Cells. 2013 Jan; 31(1):48-58. PMID: 23081664.
      View in: PubMed
    31. Home P, Saha B, Ray S, Dutta D, Gunewardena S, Yoo B, Pal A, Vivian JL, Larson M, Petroff M, Gallagher PG, Schulz VP, White KL, Golos TG, Behr B, Paul S. Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7362-7. PMID: 22529382.
      View in: PubMed
    32. Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL. Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011 Feb 25; 11:12. PMID: 21352545.
      View in: PubMed
    33. Galvin-Burgess KE, Vivian JL. Transforming growth factor-beta superfamily in mouse embryonic stem cell self-renewal. Vitam Horm. 2011; 87:341-65. PMID: 22127250.
      View in: PubMed
    34. Feng Y, Yang Y, Ortega MM, Copeland JN, Zhang M, Jacob JB, Fields TA, Vivian JL, Fields PE. Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood. 2010 Nov 25; 116(22):4483-91. PMID: 20798234.
      View in: PubMed
    35. Galvin KE, Travis ED, Yee D, Magnuson T, Vivian JL. Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem. 2010 Jun 25; 285(26):19747-56. PMID: 20427282.
      View in: PubMed
    36. Dutta D, Ray S, Vivian JL, Paul S. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem. 2008 Sep 12; 283(37):25404-25413. PMID: 18625704.
      View in: PubMed
    37. Kirn-Safran CB, Oristian DS, Focht RJ, Parker SG, Vivian JL, Carson DD. Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29. Dev Dyn. 2007 Feb; 236(2):447-60. PMID: 17195189.
      View in: PubMed
    38. Chen Y, Vivian JL, Magnuson T. Gene-based chemical mutagenesis in mouse embryonic stem cells. Methods Enzymol. 2003; 365:406-15. PMID: 14696361.
      View in: PubMed
    39. Playford D, Kulkarni H, Thomas M, Vivian J, Low A, Mander J, Perlman D, Finch P. Intra-ureteric capsaicin in loin pain haematuria syndrome: efficacy and complications. BJU Int. 2002 Oct; 90(6):518-21. PMID: 12230608.
      View in: PubMed
    40. Vivian JL, Olson EN, Klein WH. Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature. Dev Biol. 2000 Aug 01; 224(1):29-41. PMID: 10898959.
      View in: PubMed
    41. Vivian JL, Klein WH, Hasty P. Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. Biotechniques. 1999 Jul; 27(1):154-62. PMID: 10407678.
      View in: PubMed
    42. Vivian JL, Gan L, Olson EN, Klein WH. A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 01; 208(1):44-55. PMID: 10075840.
      View in: PubMed
    43. Myer A, Wagner DS, Vivian JL, Olson EN, Klein WH. Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo. Dev Biol. 1997 May 15; 185(2):127-38. PMID: 9187078.
      View in: PubMed
    44. Venuti JM, Morris JH, Vivian JL, Olson EN, Klein WH. Myogenin is required for late but not early aspects of myogenesis during mouse development. J Cell Biol. 1995 Feb; 128(4):563-76. PMID: 7532173.
      View in: PubMed
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