Jonathan B. Wagner, DO
Title | Physician and Interim Division Director, Clinical Pharmacology, Toxicology & Therapeutic Innovation |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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vCard | Download vCard |
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Title | Associate Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Biography Kansas City University of Medicine and Biosciences, Kansas City, MO | DO | 2007 | | Children’s Mercy Hospital and Clinics, Kansas City, MO | Internsip | 2008 | Pediatrics | Children’s Mercy Hospital and Clinics, Kansas City, MO | Residency | 2010 | Pediatrics | Penn State Milton S. Hershey Medical Center, Hershey, PA | Fellowship | 2011 | Pediatric Cardiology | Children’s Mercy Hospital and Clinics, Kansas City, MO | Fellowship | 2013 | Pediatric Cardiology | Children’s Mercy Hospital and Clinics, Kansas City, MO | Fellowship | 2014 | Pediatric Clinical Pharmacology |
2020 | Golden Apple Mercy Mentor Award, Children's Mercy | 2018 | Department of Pediatrics Research Achievement Award, Children's Mercy | 2016 | Early Career Investigator Award Finalist, American Heart Association | 2015 | You’re the Cure Lobby Day on the Hill Scholarship Winner, American Heart Association | 2013 | Alpha Omega Alpha Honor Medical Society, UMKC SOM | 2013 | Fellow Educator of the Year Finalist, Children's Mercy | 2007 | Magna Cum Laude Latin Honors, Kansas City University of Medicine and Biosciences | 2003 - 2007 | Sigma Sigma Phi Academic/Service Honor Fraternity , Kansas City University of Medicine and Biosciences | 2003 - 2007 | Psi Sigma Alpha Honor Fraternity , Kansas City University of Medicine and Biosciences | 2005 | Mary Colleen Alderman Excellence in Pediatric Finalist , Kansas City University of Medicine and Biosciences | 2003 | Cum Laude Latin Honors, University of Missouri-Columbia | 2003 | Honor Biochemistry Scholar, University of Missouri-Columbia | 1997 | Eagle Scout, Boy Scouts of America |
Overview Research Jonathan Wagner, DO, FAAP, graduated with a bachelor of science degree in biochemistry with cum laude latin honors from the University of Missouri-Columbia and received his medical degree with magna cum laude honors from Kansas City University of Medicine and Biosciences. He completed pediatrics residency at Children’s Mercy, followed by a dual fellowship training in pediatric cardiology and pediatric clinical pharmacology. Dr. Wagner joined our faculty in 2013. His early career research involved the impact of genetic variation and development on statin disposition during childhood. His series of pharmacogenomics driven pharmacokinetic studies involving statins has contributed to further understanding of inter-individual variability of statin response in the pediatric population. Dr. Wagner has served as a site-primary investigator for the Fontan Udenafil Exercise Longitudinal (FUEL) and Fontan Associated Liver Disease (FALD) trials sponsored by the Pediatric Heart Network (NHLBI). He is director of the Cardiology Pharmacogenomics Repository (CPR) at Children’s Mercy Kansas City (CMKC). Dr. Wagner has been honored as a finalist for the 2016 AHA Scientific Sessions Council of Cardiovascular Disease in the Young Early Career Award and the CMKC Department of Pediatrics Research Achievement Award in 2018. He has received over 2.5 million dollars in external funding from the American Heart Association, Thrasher Research Fund, and the National Institutes of Health (NIH) to support his research programs involving pediatric cardiovascular disease and pediatric clinical pharmacology. His NIH funding from the Frontiers KL2 Clinical and Transitional Mentored Career Development Award has supported his Statin Optimization in Pediatrics program. More recently, he was awarded the E.W. "Al" Thrasher Established Investigator Award for his work exploring the effects of pediatric liver adiposity on statin disposition and response. Dr. Wagner serves on the Advisory Council on Rare Disease and Personalized Medicine for Missouri Health Net division of the Missouri Department of Social Services. He is a member of the American Heart Association (AHA) Kansas City Board of Directors and remains involved in the State of Kansas AHA Advocacy Committee. He has presented at multiple local and national meetings, has over 25 peer-review publications, authored several books chapters and serves as an editorial board member of Clinical and Translational Sciences. Dr. Wagner currently serves as the Division Director of Clinical Pharmacology, Toxicology, and Therapeutic Innovation and remains an active member of the Ward Family Heart Center involved in cardiovascular intensive care, congenital heart disease and cardiovascular genetics. Dr. Wagner’s passion involves clinical integration of pharmacogenomics and precision medicine into routine cardiovascular care, but his true passion is spending quality time with his wife (Margo) and 2 boys (Oliver and Teddy) when not busy at work.
13CRP16940091 (Wagner, Jonathan)Jul 1, 2013 American Heart Association Midwest Affiliate Clinical Research Program Pharmacokinetics of pravastatin and simvastatin in pediatric dyslipidemia patients: Clinical impact of genetic variation in statin disposition Role Description: Award declined due to acceptance of AHA National Affiliate Grant Role: Primary Investigator |
| Thrasher Research Fund Early Career Award Program (Wagner, Jonathan)Jul 1, 2013 Thrasher Research Fund Pharmacokinetics of pravastatin and simvastatin in pediatric dyslipidemia patients: Clinical impact of genetic variation in statin disposition Role Description: Award declined due to acceptance of AHA Grant Role: Primary Investigator |
| Children’s Mercy Hospital Clinical Fellowship Rese (Wagner, Jonathan)Jul 1, 2013 - Jun 30, 2015 Children's Mercy Hospital Cardiology Pharmacogenomics Repository Role: Primary Investigator |
| 13CRP17110023 (Wagner, Jonathan)Jul 1, 2013 - Jun 30, 2016 American Heart Association National Affiliate Clinical Research Program Pharmacokinetics of pravastatin and simvastatin in pediatric dyslipidemia patients: Clinical impact of genetic variation in statin disposition Role: Primary Investigator |
| Marion Merrell Dow Clinical Scholar Award (Wagner, Jonathan)Jul 1, 2014 - Aug 1, 2017 Children’s Mercy Kansas City Pharmacokinetics of rosuvastatin and atorvastatin in pediatric dyslipidemia patients: Clinical impact of genetic variation in statin disposition Role: Primary Investigator |
| 1 U10 HL068270 (Paridon, Stephen)Jul 1, 2015 - Dec 31, 2019 NHLBI (PHN) Fontan Udenafil Exercise Longitudinal (FUEL) Assessment Trial Role: Site Primary Investigator |
| 1 U10 HL068270 (Paridon, Stephen)May 1, 2017 NHLBI (PHN) A Phase III Safety Extension Study of Udenafil in Adolescents with Single Ventricle Physiology after Fontan Palliation (FUEL Extension) Role: Site Primary Investigator |
| KL2TR002367 (Wagner, Jonathan)Sep 1, 2017 - Jun 30, 2020 NCATS (Frontiers Clinical and Translational Science Institute) Statin Optimization in Pediatrics Role: Primary Investigator |
| 1 U54 HD090258-02 (Leeder, J. Stephen)Apr 1, 2018 - Apr 1, 2020 NICHD GOLDILOKs: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids Role Description: Pilot Project: Validation of OATP Endogenous Biomarkers in Children. Role: Pilot Project Primary Investigator |
| 1 U10 HL068270 (Wagner, Jonathan)Jul 2, 2018 NHLBI (PHN) Imaging and Biomarker Evaluation of Hepatic Stiffness in Children Enrolled in the Fontan Udenafil Exercise Longitudinal Study (FALD Ancillary Study) Role: Site Primary Investigator |
| Pilot Grant (McCoin, Colin)Jul 1, 2019 University of Kansas Medical/Children’s Mercy Hospital Statin Therapy in Children: Mitochondrial and Physical Function Role: Co-Investigator |
| (Wagner, Jonathan)Nov 1, 2020 - Oct 31, 2023 Thrasher Research Fund Effects of Pediatric Liver Adiposity on Statin Disposition and Response Role: Primary Investigator |
| (Wagner, Jonathan)Jul 1, 2021 - Jun 30, 2022 Frontiers Clinical and Translational Science Institute: Lauren S. Aaronson Frontiers Clinical and Translational Research Pilot Study Program Effects of Liver Adiposity on the Pharmacometabolomics of Statin Disposition and Response in Children Role: Primary Investigator |
| 1T32HD069038-11 (WAGNER, JONATHON)Mar 1, 2022 NICHD Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology Role: PRINCIPLE INVESTIGATOR |
Bibliography
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Krzywda K, Teson KM, Watson JS, Goudar S, Forsha D, Wagner JB, White D. Peak Oxygen Consumption (VO2peak) Recovery Delay in a Pediatric Fontan Population. Med Sci Sports Exerc. 2023 Jul 03. PMID: 37418236.
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Goldberg DJ, Hu C, Lubert AM, Rathod RH, Penny DJ, Petit CJ, Schumacher KR, Ginde S, Williams RV, Yoon JK, Kim GB, Nowlen TT, DiMaria MV, Frischhertz BP, Wagner JB, McHugh KE, McCrindle BW, Cartoski MJ, Detterich JA, Yetman AT, John AS, Richmond ME, Yung D, Payne RM, Mackie AS, Davis CK, Shahanavaz S, Hill KD, Almaguer M, Zak V, McBride MG, Goldstein BH, Pearson GD, Paridon SM. The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis. Pediatr Cardiol. 2023 Jun 29. PMID: 37382636.
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Palmen R, Sandritter T, Malloy-Walton L, Follansbee C, Wagner JB. Case report: Use of therapeutic drug monitoring and pharmacogenetic testing as opportunities to individualize care in a case of flecainide toxicity after fetal supraventricular tachycardia. Front Pediatr. 2023; 11:1168619. PMID: 37449265.
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Ramsey LB, Gong L, Lee SB, Wagner JB, Zhou X, Sangkuhl K, Adams SM, Straka RJ, Empey PE, Boone EC, Klein TE, Niemi M, Gaedigk A. PharmVar GeneFocus: SLCO1B1. Clin Pharmacol Ther. 2023 04; 113(4):782-793. PMID: 35797228.
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Ramsey L, Sprowl J, Leeder S, Wagner JB. In Tsongalis G eds. Advances in Molecular Pathology. SLCO1B1 Pharmacogenomics in Pediatrics. 2022.
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Stancil SL, Abdel-Rahman S, Wagner J. Developmental Considerations for the Use of Naltrexone in Children and Adolescents. J Pediatr Pharmacol Ther. 2021; 26(7):675-695. PMID: 34588931.
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Friesen CS, Hosey-Cojocari C, Chan SS, Csanaky IL, Wagner JB, Sweeney BR, Friesen A, Fraser JD, Shakhnovich V. Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy. Front Endocrinol (Lausanne). 2021; 12:663351. PMID: 33927697.
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Friesen CS, Chan SS, Wagner JB, Hosey-Cojocari C, Csanaky IL, Shakhnovich V. Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective. Clin Transl Sci. 2021 05; 14(3):781-783. PMID: 33476465.
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Villafane J, Miller JR, Glickstein J, Johnson JN, Wagner J, Snyder CS, Filina T, Pomeroy SL, Sexson-Tejtel SK, Haxel C, Gottlieb J, Eghtesady P, Chowdhury D. Loss of Consciousness in the Young Child. Pediatr Cardiol. 2021 Feb; 42(2):234-254. PMID: 33388850.
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Wagner JB, Ruggiero M, Leeder JS, Hagenbuch B. Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport. Drug Metab Dispos. 2020 11; 48(11):1192-1198. PMID: 32892153.
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Wagner JB, Abdel-Rahman S, Gaedigk A, Gaedigk R, Raghuveer G, Staggs VS, Van Haandel L, Leeder JS. Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia. Clin Transl Sci. 2020 05; 13(3):628-637. PMID: 31981411.
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Goldberg DJ, Zak V, Goldstein BH, Schumacher KR, Rhodes J, Penny DJ, Petit CJ, Ginde S, Menon SC, Kim SH, Kim GB, Nowlen TT, DiMaria MV, Frischhertz BP, Wagner JB, McHugh KE, McCrindle BW, Shillingford AJ, Sabati AA, Yetman AT, John AS, Richmond ME, Files MD, Payne RM, Mackie AS, Davis CK, Shahanavaz S, Hill KD, Garg R, Jacobs JP, Hamstra MS, Woyciechowski S, Rathge KA, McBride MG, Frommelt PC, Russell MW, Urbina EM, Yeager JL, Pemberton VL, Stylianou MP, Pearson GD, Paridon SM. Results of the FUEL Trial. Circulation. 2020 02 25; 141(8):641-651. PMID: 31736357.
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Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich V. Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children. Paediatr Drugs. 2019 Oct; 21(5):357-369. PMID: 31432433.
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Wagner JB. Genomics and Precision Medicine to Direct Statin Use in the Young. Prog Pediatr Cardiol. 2009 Sep; 54. PMID: 32855589.
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Ogungbenro K, Wagner JB, Abdel-Rahman S, Leeder JS, Galetin A. A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents. Eur J Clin Pharmacol. 2019 Sep; 75(9):1227-1235. PMID: 31172248.
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Wagner JB. Children Are Not Small Adults: Specific Findings in Statin Exposure and Response in a Growing Population. Clin Pharmacol Ther. 2019 08; 106(2):278-280. PMID: 30970165.
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Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS. Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia. Clin Pharmacol Ther. 2019 06; 105(6):1501-1512. PMID: 30549267.
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McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 03; 12(2):140-150. PMID: 30516322.
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Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS. Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics. J Clin Pharmacol. 2018 06; 58(6):823-833. PMID: 29469964.
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Wagner JB, Knowlton JQ, Pastuszko P, Shah SS. A Rare Case of Vascular Ring and Coarctation of the Aorta in Association with CHARGE Syndrome. Tex Heart Inst J. 2017 Apr; 44(2):138-140. PMID: 28461801.
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Wagner J, Abdel-Rahman SM. Pediatric Statin Administration: Navigating a Frontier with Limited Data. J Pediatr Pharmacol Ther. 2016 Sep-Oct; 21(5):380-403. PMID: 27877092.
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van Haandel L, Gibson KT, Leeder JS, Wagner JB. Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15; 1012-1013:169-77. PMID: 26849185.
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Wagner J, Abdel-Rahman SM. Oseltamivir-warfarin interaction in hypoplastic left heart syndrome: case report and review. Pediatrics. 2015 May; 135(5):e1333-6. PMID: 25917992.
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Wagner J, Abdel-Rahman SM. Pediatric pharmacokinetics. Pediatr Rev. 2013 Jun; 34(6):258-69. PMID: 23729775.
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Tisma-Dupanovic S, Wagner JB, Shah S, Huang DT, Moss AJ. An adolescent with possible arrhythmogenic right ventricular dysplasia and long QT syndrome: evaluation and management. Ann Noninvasive Electrocardiol. 2013 Jan; 18(1):75-8. PMID: 23347029.
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Wagner J, Leeder JS. Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children. Pediatr Clin North Am. 2012 Oct; 59(5):1017-37. PMID: 23036242.
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Ramsey L, Sprowl J, Leeder S, Wagner JB. . SLCO1B1 Pharmacogenetics in Pediatrics.
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2012 | 1 | 2013 | 2 | 2015 | 1 | 2016 | 2 | 2017 | 1 | 2018 | 1 | 2019 | 7 | 2020 | 2 | 2021 | 4 | 2022 | 2 | 2023 | 3 |
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