 Stephani L. Stancil, PhD, APRN
| Title | Clinician Scientist, Adolescent Medicine |
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| Institution | Children's Mercy Kansas City |
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| Department | Pediatrics |
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| Address | 3101 Broadway Boulevard
Kansas City MO 64111
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ORCID
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| vCard | Download vCard |
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| Title | Assistant Professor |
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| Institution | University of Missouri-Kansas City |
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| Department | Pediatrics |
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 Biography | Children's Mercy Hospital, Kansas City, MO | T32 Fellowship | 08/2020 | Pediatric Clinical Pharmacology | | University of Missouri Kansas City, Kansas City, MO | Ph.D | 07/2018 | Pharmacology and Pharmaceutical Science | | University of Kansas, Lawrence, KS | MS | 08/2009 | Family Nurse Practitioner |
| 2019 | National Magnet Nurse of the Year - Exemplary Professional Practice, American Nurses Credentialing Center (ANCC) | | 2022 | Research Achievement - Early Career Faculty, Children's Mercy Department of Pediatrics |
Overview Research Stephani Stancil, PhD, APRN is an adolescent medicine clinician scientist in the Divisions of Adolescent Medicine and Clinical Pharmacology, Toxicology and Therapeutic Innovation at Children's Mercy and an assistant professor in the Department of Pediatrics at the University of Missouri-Kansas City School of Medicine. For over a decade, her clinical practice has focused on complex teens in specialized and vulnerable populations. Her interdisciplinary, translational research focuses on developing precision therapeutics for adolescent mental health conditions by understanding variability in exposure and response. Her other research interests include improving reproductive health care in teens and reducing risks of vulnerable youth. She recently served as an editor-in-training for the ASCPT journal, Clinical and Translational Science and now serves on their editorial board.
K23MH130728 NIMH
Development of a Pharmacodynamic Biomarker of Opioid Antagonism in Adolescents with Eating Disorders
Role Description: Eating disorders are common in adolescents, increase the risk of substance use, have the highest mortality rate of any psychiatric illness and are not responsive to current pharmacotherapy. The overall goal of this K23 proposal is to evaluate neuroimaging as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders through practical application of training in neuroimaging, pediatric randomized clinical trials and exposure-response modeling. At the completion of this proposal, Dr. Stephani Stancil will be well- positioned for an independent career as an interdisciplinary translational scientist focused on pharmacodynamic biomarker development to support early-stage drug development in pediatric neuropsychopharmacology.
Role: Primary Investigator |
| T32HD069038 (WAGNER, JONATHAN)May 1, 2011 - Apr 30, 2026 NIH
Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Role: Fellow |
| (Miller, Melissa K)Jun 15, 2014 - Jun 14, 2015 Kansas City Area Life Sciences Institute
Novel computerized decision support system to increase access to sexual health services for adolescents in the emergency department
Role: Co-Investigator |
| Young Investigator Award (Stancil, Stephani L)Jul 1, 2014 - Jun 30, 2016 Children's Mercy
Exploring the effects of nicotine and ethinyl estradiol on the metabolism of metronidazole
Role: Primary Investigator |
| Katharine B. Richardson Award (Stancil, Stephani L)Jan 1, 2016 - Dec 31, 2017 Children's Mercy
Validation of a novel CYP2A6 in vivo phenotyping probe in healthy adults
Role: Primary Investigator |
| K23HD083405 (MILLER, MELISSA KRISTINE)May 11, 2016 - Apr 30, 2020 NIH
Enhanced Intervention to Improve Adolescent Outcomes: A Clinical Trial
Role: Co-Investigator |
| U54HD090258 (LEEDER, JAMES STEVEN)Sep 23, 2016 - Jun 30, 2021 NIH
Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Role: Pilot project PI |
| Fellow's Award (Stancil, Stephani L)Jul 1, 2019 - Jun 30, 2021 Children's Mercy
Eating Disorder Individualized Therapeutics-Naltrexone
Role: Primary Investigator |
| R21HD098086 (MILLER, MELISSA KRISTINE)May 22, 2020 - Apr 30, 2022 NIH
Multi-level Emergency Department Intervention to Reduce Pregnancy Risk Among Adolescents
Role: Co-Investigator |
| (Masonbrink, Abbey)Jun 1, 2020 - May 31, 2022 Merck
Intervention to Facilitate Contraception Provision by Pediatric Hospitalists: A Feasibility Study
Role: Co-Investigator |
| (Stancil, Stephani L)Aug 10, 2020 - Dec 31, 2020 CARES Act
Smarter together: A MidWest collaboration to develop best practices for community youth shelters facing COVID-19
Role: Primary Investigator |
| UL1TR002366 Jul 1, 2021 - Jun 30, 2022 NCATS
Eating Disorder Individualized Therapeutics - Naltrexone Neuroimaging
Role: Primary Investigator (pilot grant recipient) |
| (Stephani Stancil)Jan 1, 2022 - Dec 31, 2023 Paul Patton Trust
Antidepressant Exposure in the Adolescent Brain
Role: Co-Primary Investigator |
| KL2TR002367 (Stephani Stancil)Jul 29, 2022 - Jun 30, 2023 NCATS
Development of a Pharmacodynamic Biomarker of Opioid Antagonism
Role: Primary Investigator |
Bibliography
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Stimpfl JN, Walkup JT, Robb AS, Alford AE, Stahl SM, McCracken JT, Stancil SL, Ramsey LB, Emslie GJ, Strawn JR. Deprescribing Antidepressants in Children and Adolescents: A Systematic Review of Discontinuation Approaches, Cross-Titration, and Withdrawal Symptoms. J Child Adolesc Psychopharmacol. 2024 Oct 29. PMID: 39469761.
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Parvez MM, Thakur A, Mehrotra A, Stancil S, Pearce RE, Basit A, Leeder JS, Prasad B. Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling. Clin Pharmacol Ther. 2024 Oct; 116(4):1090-1099. PMID: 38955794.
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Miller MK, Goggin K, Stancil SL, Miller E, Ketterer T, Staggs V, McNeill-Johnson AD, Adams A, Mollen CJ. Feasibility of adolescent contraceptive care in the pediatric emergency department: A pilot randomized controlled trial. Acad Emerg Med. 2024 Nov; 31(11):1100-1111. PMID: 38881403.
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McNeill-Johnson A, Miller M, Stancil S, Randell KA. Sexual and Reproductive Health Care Utilization for Youth Experiencing Homelessness. Clin Pediatr (Phila). 2024 Apr 29; 99228241249403. PMID: 38682641.
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Stancil SL, Sandritter T, Strawn JR. Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02. J Child Adolesc Psychopharmacol. 2024 02; 34(1):61-66. PMID: 38377523.
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Stancil SL, Pearce RE, Staggs VS, Leeder JS. Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver. Drug Metab Dispos. 2023 Dec; 51(12):1578-1582. PMID: 37735064.
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Stancil SL, Yeh HW, Brucks MG, Bruce AS, Voss M, Abdel-Rahman S, Brooks WM, Martin LE. Potential biomarker of brain response to opioid antagonism in adolescents with eating disorders: a pilot study. Front Psychiatry. 2023; 14:1161032. PMID: 37492067.
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Masonbrink AR, Noel-MacDonnell J, Staggs VS, Stancil S, Goggin K, Miller MK. Feasibility of a Contraception Intervention for Hospitalized Adolescents and Young Adults. Hosp Pediatr. 2023 04 01; 13(4):337-344. PMID: 36897226.
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Stancil SL, Voss M, Nolte W, Tumberger J, Adelman W, Abdel-Rahman S. Effects of genotype and food on naltrexone exposure in adolescents. Clin Transl Sci. 2022 11; 15(11):2732-2743. PMID: 36200172.
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Stancil SL, Tumberger J, Strawn JR. Target to treatment: A charge to develop biomarkers of response and tolerability in child and adolescent psychiatry. Clin Transl Sci. 2022 04; 15(4):816-823. PMID: 34913258.
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Stancil SL, Nolte W, Pearce RE, Staggs VS, Leeder JS. The Impact of Age and Genetics on Naltrexone Biotransformation. Drug Metab Dispos. 2022 02; 50(2):168-173. PMID: 34728519.
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Stancil SL, Abdel-Rahman S, Wagner J. Developmental Considerations for the Use of Naltrexone in Children and Adolescents. J Pediatr Pharmacol Ther. 2021; 26(7):675-695. PMID: 34588931.
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Stancil SL, Miller MK, Duello A, Finocchario-Kessler S, Goggin K, Winograd RP, Hurley EA. Long-acting reversible contraceptives (LARCs) as harm reduction: a qualitative study exploring views of women with histories of opioid misuse. Harm Reduct J. 2021 08 04; 18(1):83. PMID: 34348734.
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Stancil SL, Mirzayev F, Abdel-Rahman SM. Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date. Drug Des Devel Ther. 2021; 15:2815-2830. PMID: 34234413.
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Miller MK, Catley D, Adams A, Staggs VS, Dowd MD, Stancil SL, Miller E, Satterwhite CL, Bauermeister J, Goggin K. Brief Motivational Intervention to Improve Adolescent Sexual Health Service Uptake: A Pilot Randomized Controlled Trial in the Emergency Department. J Pediatr. 2021 Oct; 237:250-257.e2. PMID: 34144031.
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Stancil SL, Berrios C, Abdel-Rahman S. Adolescent perceptions of pharmacogenetic testing. Pharmacogenomics. 2021 04; 22(6):335-343. PMID: 33849282.
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Roberts TA, Wagner JA, Sandritter T, Black BT, Gaedigk A, Stancil SL. Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital. Clin Transl Sci. 2021 01; 14(1):412-421. PMID: 33048453.
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Hurley EA, Duello A, Finocchario-Kessler S, Goggin K, Stancil S, Winograd RP, Miller MK. Expanding Contraception Access for Women With Opioid-Use Disorder: A Qualitative Study of Opportunities and Challenges. Am J Health Promot. 2020 11; 34(8):909-918. PMID: 32468826.
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Stancil SL, Adelman W, Dietz A, Abdel-Rahman S. Naltrexone Reduces Binge Eating and Purging in Adolescents in an Eating Disorder Program. J Child Adolesc Psychopharmacol. 2019 11; 29(9):721-724. PMID: 31313939.
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Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969. PMID: 30706508.
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Masonbrink AR, Stancil S, Reid KJ, Goggin K, Hunt JA, Mermelstein SJ, Shafii T, Lehmann AG, Harhara H, Miller MK. Adolescent Reproductive Health Care: Views and Practices of Pediatric Hospitalists. Hosp Pediatr. 2019 02; 9(2):100-106. PMID: 30622112.
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Miller MK, Mollen C, Behr K, Dowd MD, Miller E, Satterwhite CL, Stancil S, Allen N, Michael J, Inboriboon PC, Park A, Goggin K. Development of a Novel Computerized Clinical Decision Support System to Improve Adolescent Sexual Health Care Provision. Acad Emerg Med. 2019 04; 26(4):420-433. PMID: 30240032.
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Stancil SL, van Haandel L, Abdel-Rahman S, Pearce RE. Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15; 1092:272-278. PMID: 29933220.
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Stancil SL, Miller M, Briggs H, Lynch D, Goggin K, Kearns G. Contraceptive Provision to Adolescent Females Prescribed Teratogenic Medications. Pediatrics. 2016 Jan; 137(1). PMID: 26676050.
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| Year | Publications |
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| 2015 | 1 | | 2018 | 2 | | 2019 | 3 | | 2020 | 2 | | 2021 | 6 | | 2022 | 2 | | 2023 | 3 | | 2024 | 5 |
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