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Jean-Baptiste Le Pichon, MD, PhD, FAAP

TitleDirector, Child Neurology Residency Program
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitlePhysician
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleProfessor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Baylor College of Medicine, Houston, TXMD
    Baylor College of Medicine, Houston, TXPhD
    Texas Children's Hospital, Baylor College of Medicine, Houston, TXResidencyChild Neurology
    Texas Children's Hospital, Baylor College of Medicine, Houston, TXFellowshipClinical Neurophysiology Research

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Le Pichon's research interests are broad but currently focus in two general areas of child neurology. The first area is concerned with bilirubin metabolism and toxicity in the infant. This work has resulted from a close collaboration with Dr. Steven Shapiro. Acute bilirubin encephalopathy offers an ideal disease model to study a unique form of choreoathetoid cerebral palsy in that the initial insult and its subsequent consequences are fairly well understood and affect relatively few and constant brain regions. Furthermore, while the disease is relatively well controlled in developed countries (with an incidence comparable to many rare genetic disorders), it remains a major cause of morbidity and mortality in low and middle income countries.

    Dr. Le Pichon also has a strong interest in developing fair and equitable modes of delivering medical care. This has been the force behind a major effort at improving the care of children and youth with epilepsy in underserved and rural areas.
    Collapse research activities and funding
    H98MC33239     (J.B. Le Pichon & Ahmed Abdelmoity)Sep 1, 2019 - Aug 31, 2023
    HRSA
    Reaching out for Epilepsy in Adolescents and Children through Telemedicine (REACT)
    Role Description: This project is a quality improvement project designed to create a medical home for children and youth with epilepsy in the State of Kansas. To achieve this goal the projects combines telemedicine and improved education for primary care physicians, patients and their families as well as improved detection and treatment of mental health issues common to this patient population and improved transition of care when the children reach adulthood.
    Role: Co-Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Scher MS, Breningstall G, Gilbert D, Jordan L, Khakoo Y, LePichon JB. The 2018 Pediatric Neurology Trainee Publication Award. Pediatr Neurol. 2019 Dec; 101:1. PMID: 31623938.
      View in: PubMed
    2. Gelineau-Morel RN, Zinkus TP, Le Pichon JB. Pediatric Head Trauma: A Review and Update. Pediatr Rev. 2019 Sep; 40(9):468-481. PMID: 31477589.
      View in: PubMed
    3. Ferreira JA, Le Pichon JB, Abdelmoity AT, Dilley D, Dedeken P, Daniels T, Byrnes W. Safety and tolerability of adjunctive lacosamide in a pediatric population with focal seizures - An open-label trial. Seizure. 2019 Oct; 71:166-173. PMID: 31374487.
      View in: PubMed
    4. Le Pichon JB, Thompson L, Gustafson M, Abdelmoity A. Initiating the ketogenic diet in infants with treatment refractory epilepsy while maintaining a breast milk diet. Seizure. 2019 Jul; 69:41-43. PMID: 30959424.
      View in: PubMed
    5. Scher MS, Breningstall G, Gilbert D, Jordan L, Khakoo Y, LePichon JB. The 2017 Pediatric Neurology Training Publication Award. Pediatr Neurol. 2018 09; 86:4. PMID: 30390955.
      View in: PubMed
    6. Gbadero DA, Adegbite EO, LePichon JB, Slusher TM. Case Presentation of Anti-NMDA Receptor Encephalitis in a 4-Year-Old Boy. J Trop Pediatr. 2018 Aug 01; 64(4):352-354. PMID: 29040795.
      View in: PubMed
    7. Scher MS, Breningstall G, Gilbert DL, Jordan L, Khakoo Y, LePichon JB. Editorial: The 2016 Pediatric Neurology Trainee Publication Award. Pediatr Neurol. 2017 10; 75:3. PMID: 28826612.
      View in: PubMed
    8. Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA. GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis. 2017 Oct; 106:181-190. PMID: 28688853.
      View in: PubMed
    9. Allison T, Roncero I, Forsyth R, Coffman K, Pichon JL. Brown-Vialetto-Van Laere Syndrome as a Mimic of Neuroimmune Disorders: 3 Cases From the Clinic and Review of the Literature. J Child Neurol. 2017 05; 32(6):528-532. PMID: 28116953.
      View in: PubMed
    10. Le Pichon JB, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Curr Pediatr Rev. 2017; 13(3):199-209. PMID: 28814249.
      View in: PubMed
    11. Flex E, Niceta M, Cecchetti S, Thiffault I, Au MG, Capuano A, Piermarini E, Ivanova AA, Francis JW, Chillemi G, Chandramouli B, Carpentieri G, Haaxma CA, Ciolfi A, Pizzi S, Douglas GV, Levine K, Sferra A, Dentici ML, Pfundt RR, Le Pichon JB, Farrow E, Baas F, Piemonte F, Dallapiccola B, Graham JM, Saunders CJ, Bertini E, Kahn RA, Koolen DA, Tartaglia M. Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy. Am J Hum Genet. 2016 Oct 06; 99(4):962-973. PMID: 27666370.
      View in: PubMed
    12. Riordan SM, Bittel DC, Le Pichon JB, Gazzin S, Tiribelli C, Watchko JF, Wennberg RP, Shapiro SM. A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy. Front Neurosci. 2016; 10:376. PMID: 27587993.
      View in: PubMed
    13. LePichon JB, Saunders CJ, Soden SE. The Future of Next-Generation Sequencing in Neurology. JAMA Neurol. 2015 Sep; 72(9):971-2. PMID: 26148113.
      View in: PubMed
    14. Saunders CJ, Moon SH, Liu X, Thiffault I, Coffman K, LePichon JB, Taboada E, Smith LD, Farrow EG, Miller N, Gibson M, Patterson M, Kingsmore SF, Gross RW. Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A2 ? recapitulate the mitochondriopathy of the homologous null mouse. Hum Mutat. 2015 Mar; 36(3):301-6. PMID: 25512002.
      View in: PubMed
    15. Stanford JA, Shuler JM, Fowler SC, Stanford KG, Ma D, Bittel DC, Le Pichon JB, Shapiro SM. Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. Pediatr Res. 2015 Mar; 77(3):434-9. PMID: 25518009.
      View in: PubMed
    16. Soden SE, Saunders CJ, Willig LK, Farrow EG, Smith LD, Petrikin JE, LePichon JB, Miller NA, Thiffault I, Dinwiddie DL, Twist G, Noll A, Heese BA, Zellmer L, Atherton AM, Abdelmoity AT, Safina N, Nyp SS, Zuccarelli B, Larson IA, Modrcin A, Herd S, Creed M, Ye Z, Yuan X, Brodsky RA, Kingsmore SF. Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders. Sci Transl Med. 2014 Dec 03; 6(265):265ra168. PMID: 25473036.
      View in: PubMed
    17. Batterson JR, Sullivant S, Le Pichon JB, Kleinsorge C, Price S, Andrews S. A refresher on Tourette syndrome. Mo Med. 2014 May-Jun; 111(3):202-6. PMID: 25011341.
      View in: PubMed
    18. Dlugos D, Shinnar S, Cnaan A, Hu F, Moshé S, Mizrahi E, Masur D, Sogawa Y, Le Pichon JB, Levine C, Hirtz D, Clark P, Adamson PC, Glauser T. Pretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome. Neurology. 2013 Jul 09; 81(2):150-6. PMID: 23719147.
      View in: PubMed
    19. Le Pichon JB, Yu S, Kibiryeva N, Graf WD, Bittel DC. Genome-wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome. Eur J Hum Genet. 2013 Oct; 21(10):1093-9. PMID: 23361223.
      View in: PubMed
    20. Abdelmoity AT, LePichon JB, Nyp SS, Soden SE, Daniel CA, Yu S. 15q11.2 proximal imbalances associated with a diverse array of neuropsychiatric disorders and mild dysmorphic features. J Dev Behav Pediatr. 2012 Sep; 33(7):570-6. PMID: 22922608.
      View in: PubMed
    21. Lepichon JB, Bittel DC, Graf WD, Yu S. A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes. Am J Med Genet A. 2010 May; 152A(5):1300-4. PMID: 20425840.
      View in: PubMed
    22. Graf WD, Le Pichon JB, Bittel DC, Abdelmoity AT, Yu S. Practice parameter: evaluation of the child with microcephaly (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2010 Mar 30; 74(13):1080-1; author reply 1081. PMID: 20350984.
      View in: PubMed
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