 Botulinum Toxins
"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
| Descriptor ID |
D001905
|
| MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
|
| Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
|
Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 2 | 0 | 2 | | 2022 | 2 | 0 | 2 | | 2023 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
-
Bhuiyan J, Habeshian KA, Booser AC, Gomez-Lobo V, Dowlut-McElroy T. Botulinum Toxin Injections as a Treatment of Refractory Vulvodynia in Adolescents: A Case Series. J Pediatr Adolesc Gynecol. 2023 Oct; 36(5):497-500.
-
Svetanoff WJ, Lim-Beutal IIP, Wood RJ, Levitt MA, Rentea RM. The utilization of botulinum toxin for Hirschsprung disease. Semin Pediatr Surg. 2022 Apr; 31(2):151161.
-
Rice-Townsend SE, Nicassio L, Glazer D, Avansino J, Durham MM, Calkins CM, Rentea RM, Ralls MW, Wood RJ, Rollins MD, Garvey EM, Lewis KE, Reeder R, Smith CA. Characterizing the use of botulinum toxin in patients with Hirschsprung disease treated at referral institutions for pediatric colorectal surgery. J Pediatr Surg. 2022 Jun; 57(6):1033-1039.
-
Ahmad H, Rentea RM, Knaus ME, Wilbur JG, Halaweish I, Langer JC, Levitt MA, Wood RJ. Routine botulinum toxin injection one month after a Swenson pull-through does not change the incidence of Hirschsprung associated enterocolitis. J Pediatr Surg. 2022 Aug; 57(8):1453-1457.
-
Rentea RM, Noel-MacDonnell JR, Bucher BT, Dorman MR, Lautz TB, Pruitt LCC, Oyetunji TA. Impact of Botulinum Toxin on Hirschsprung-Associated Enterocolitis After Primary Pull-Through. J Surg Res. 2021 05; 261:95-104.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|