Tetanus Toxin

"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.

Descriptor ID	D013744
MeSH Number(s)	D12.776.097.872 D23.946.123.893
Concept/Terms	Tetanus Toxin Tetanus Toxin Toxin, Tetanus Clostridium tetani Toxin Toxin, Clostridium tetani Tetanus Toxins Toxins, Tetanus Clostridial Neurotoxin Clostridial Neurotoxin Neurotoxin, Clostridial

Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
Tetanus Toxin [D12.776.097.872]
Biological Factors [D23]
Toxins, Biological [D23.946]
Bacterial Toxins [D23.946.123]
Tetanus Toxin [D23.946.123.893]

Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".

publications

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