Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.
| Descriptor ID |
D055504
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| MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.039 D12.776.476.024.382
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
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Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles.
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Fu Q, McKnight RA, Yu X, Callaway CW, Lane RH. Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. FASEB J. 2006 Oct; 20(12):2127-9.