Crk-Associated Substrate Protein
"Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
Descriptor ID |
D050719
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MeSH Number(s) |
D12.644.360.024.295 D12.776.157.057.022 D12.776.476.024.374 D12.776.744.425
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Concept/Terms |
Crk-Associated Substrate Protein- Crk-Associated Substrate Protein
- Crk Associated Substrate Protein
- Substrate Protein, Crk-Associated
- Breast Cancer Anti-Estrogen Resistance 1 Protein
- Breast Cancer Anti Estrogen Resistance 1 Protein
- CKRAS Protein
- p130 Cas Protein
- Cas Protein, p130
- p130 Crk-Associated Substrate
- Crk-Associated Substrate, p130
- Substrate, p130 Crk-Associated
- p130 Crk Associated Substrate
- p130Cas Protein
- BCAR1 Protein
- Crk-Associated Substrate
- Crk Associated Substrate
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Below are MeSH descriptors whose meaning is more general than "Crk-Associated Substrate Protein".
Below are MeSH descriptors whose meaning is more specific than "Crk-Associated Substrate Protein".
This graph shows the total number of publications written about "Crk-Associated Substrate Protein" by people in this website by year, and whether "Crk-Associated Substrate Protein" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2012 | 0 | 1 | 1 | 2013 | 0 | 1 | 1 | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Crk-Associated Substrate Protein" by people in Profiles.
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Douglas JT, Johnson DK, Roy A, Park T. Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis. Methods Enzymol. 2024; 698:301-342.
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Park TJ, Curran T. Essential roles of Crk and CrkL in fibroblast structure and motility. Oncogene. 2014 Oct 23; 33(43):5121-32.
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George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb; 122(2):674-92.
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