 Tandem Mass Spectrometry
"Tandem Mass Spectrometry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
| Descriptor ID |
D053719
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| MeSH Number(s) |
E05.196.566.880
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| Concept/Terms |
Tandem Mass Spectrometry- Tandem Mass Spectrometry
- Mass Spectrometry, Tandem
- Mass Spectrometry-Mass Spectrometry
- Mass Spectrometry Mass Spectrometry
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Below are MeSH descriptors whose meaning is more general than "Tandem Mass Spectrometry".
Below are MeSH descriptors whose meaning is more specific than "Tandem Mass Spectrometry".
This graph shows the total number of publications written about "Tandem Mass Spectrometry" by people in this website by year, and whether "Tandem Mass Spectrometry" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2006 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tandem Mass Spectrometry" by people in Profiles.
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Thakur A, Yue G, Ahire D, Mettu VS, Al Maghribi A, Ford K, Peixoto L, Leeder JS, Prasad B. Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans? Clin Pharmacol Ther. 2024 Jul; 116(1):235-246.
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Tessman RT, Nolte W, Toren P, Gibson K, Vu L, Goldman J. Simultaneous quantification of trimethoprim metabolites in pediatric plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 May 15; 1198:123232.
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He Q, Chhonker YS, McLaughlin MJ, Murry DJ. Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 08; 25(2).
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Li CY, Hosey-Cojocari C, Basit A, Unadkat JD, Leeder JS, Prasad B. Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples. AAPS J. 2019 07 11; 21(5):88.
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Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B. Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism. Drug Metab Dispos. 2019 08; 47(8):818-831.
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Stancil SL, van Haandel L, Abdel-Rahman S, Pearce RE. Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15; 1092:272-278.
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Tolbert JA, Bai S, Abdel-Rahman SM, August KJ, Weir SJ, Kearns GL, Neville KA. Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8).
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Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B. Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. Drug Metab Dispos. 2017 02; 45(2):216-223.
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van Haandel L, Gibson KT, Leeder JS, Wagner JB. Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15; 1012-1013:169-77.
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Deng S, Kiscoan M, Frazee C, Abdel-Rahman S, Dalal J, Garg U. A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantitation of Plasma Busulfan. Methods Mol Biol. 2016; 1383:79-87.
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