Tumor Suppressor Protein p14ARF
"Tumor Suppressor Protein p14ARF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
| Descriptor ID |
D025803
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| MeSH Number(s) |
D12.776.167.600 D12.776.624.776.772
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p14ARF".
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Below are the most recent publications written about "Tumor Suppressor Protein p14ARF" by people in Profiles.
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Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 2001 Jan 15; 61(2):513-6.