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Paul C. Toren, PhD

TitleDirector, Analytical Chemistry Core
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Purdue University, West Lafayette, INPh.DAnalytical Medicinal Chemistry

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    Collapse research overview
    Dr. Toren has a broad background in a variety of aspects of Mass Spectrometry with a current focus on small molecule LCMS. He's facilitated numerous projects in fields of drug development (both non-clinical and clinical research), bioanalysis and drug metabolism. Current projects include analysis of antidepressants, neurotransmitters and medications related to ADHD, autism and related disease states.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Altman RA, Sharma KK, Rajewski LG, Toren PC, Baltezor MJ, Pal M, Karad SN. Tyr1-?[( Z)CF-CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin. ACS Chem Neurosci. 2018 07 18; 9(7):1735-1742. PMID: 29648788.
      View in: PubMed
    2. Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A. High-resolution mass spectrometry elucidates metabonate (false metabolite) formation from alkylamine drugs during in vitro metabolite profiling. Drug Metab Dispos. 2012 Oct; 40(10):1966-75. PMID: 22798552.
      View in: PubMed
    3. Ogilvie BW, Yerino P, Kazmi F, Buckley DB, Rostami-Hodjegan A, Paris BL, Toren P, Parkinson A. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug Metab Dispos. 2011 Nov; 39(11):2020-33. PMID: 21795468.
      View in: PubMed
    4. Parkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BW. An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes. Drug Metab Dispos. 2011 Aug; 39(8):1370-87. PMID: 21525169.
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    5. Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos. 2006 Jan; 34(1):191-7. PMID: 16299161.
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    6. Reith K, Keung A, Toren PC, Cheng L, Eller MG, Weir SJ. Disposition and metabolism of 14C-rifapentine in healthy volunteers. Drug Metab Dispos. 1998 Aug; 26(8):732-8. PMID: 9698286.
      View in: PubMed
    7. Emary WB, Toren PC, Mathews B, Huh K. Disposition and metabolism of rifapentine, a rifamycin antibiotic, in mice, rats, and monkeys. Drug Metab Dispos. 1998 Aug; 26(8):725-31. PMID: 9698285.
      View in: PubMed
    8. Margaret Van Heek; David Schmitt; Paul Toren; Martha K. Cathcart and Paul E. DiCorleto. Cholesteryl Hydroperoxyoctadecadienoate from Oxidized Low Density Lipoprotein Inactivates Platelet-derived Growth Factor. 1998.
    9. Heath TG, Massad DD, Carroll JI, Mathews BS, Chang J, Scott DO, Kuo BS, Toren PC. Quantification of a dual angiotensin I-converting enzyme-neutral endopeptidase inhibitor and the active thiol metabolite in dog plasma by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Biomed Appl. 1995 Aug 04; 670(1):91-101. PMID: 7493089.
      View in: PubMed
    10. Toren P, Smith D, Chance R, Hoffman J. Determination of interchain crosslinkages in insulin B-chain dimers by fast atom bombardment mass spectrometry. Anal Biochem. 1988 Mar; 169(2):287-99. PMID: 3289414.
      View in: PubMed
    11. Hortin G, Fok KF, Toren PC, Strauss AW. Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin. J Biol Chem. 1987 Mar 05; 262(7):3082-5. PMID: 2434496.
      View in: PubMed
    12. Emary, WB; Cooks, RG; Toren, Paul. Binding of First and Subsequent Glycerol Molecules to Organic and Inorganic Cations Studied by Desolvation in the Mass Spectrometer. 1986.
    13. Paul C. Toren; David F. Betscha; H. Lee Weitha; James M. Coulla. Analytical Biochemistry. Determination of impurities in nucleoside 3'-phosphoramidites by fast atom bombardment mass spectrometry. 1986; 152(2):291-294.
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