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Paul C. Toren, PhD

TitleDirector, Analytical Chemistry Core
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Purdue University, West Lafayette, INPh.DAnalytical Medicinal Chemistry

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    Dr. Toren has a broad background in a variety of aspects of Mass Spectrometry with a current focus on small molecule LCMS. He's facilitated numerous projects in fields of drug development (both non-clinical and clinical research), bioanalysis and drug metabolism. Current projects include analysis of antidepressants, neurotransmitters and medications related to ADHD, autism and related disease states.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Friesen CS, Shakhnovich V, Toren P, Retke B, Schurman J, Colombo J, Deacy A, Friesen CA, Abdel-Rahman S. A Pilot Study of Ketotifen in Patients Aged 8-17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia. Paediatr Drugs. 2024 Jul; 26(4):451-457. PMID: 38771467.
      View in: PubMed
    2. Kyler KE, Gaedigk A, Abdel-Rahman S, Staggs VS, Pearce RE, Toren P, Leeder JS, Shakhnovich V. Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children. Clin Transl Sci. 2024 04; 17(4):e13782. PMID: 38629502.
      View in: PubMed
    3. Tessman RT, Nolte W, Toren P, Gibson K, Vu L, Goldman J. Simultaneous quantification of trimethoprim metabolites in pediatric plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 May 15; 1198:123232. PMID: 35428009.
      View in: PubMed
    4. Chapron BD, Dinh JC, Toren PC, Gaedigk A, Leeder JS. The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites. Drug Metab Dispos. 2020 11; 48(11):1113-1120. PMID: 32847865.
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    5. Altman RA, Sharma KK, Rajewski LG, Toren PC, Baltezor MJ, Pal M, Karad SN. Tyr1-?[( Z)CF-CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin. ACS Chem Neurosci. 2018 07 18; 9(7):1735-1742. PMID: 29648788.
      View in: PubMed
    6. Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A. High-resolution mass spectrometry elucidates metabonate (false metabolite) formation from alkylamine drugs during in vitro metabolite profiling. Drug Metab Dispos. 2012 Oct; 40(10):1966-75. PMID: 22798552.
      View in: PubMed
    7. Ogilvie BW, Yerino P, Kazmi F, Buckley DB, Rostami-Hodjegan A, Paris BL, Toren P, Parkinson A. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug Metab Dispos. 2011 Nov; 39(11):2020-33. PMID: 21795468.
      View in: PubMed
    8. Parkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BW. An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes. Drug Metab Dispos. 2011 Aug; 39(8):1370-87. PMID: 21525169.
      View in: PubMed
    9. Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos. 2006 Jan; 34(1):191-7. PMID: 16299161.
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    10. Reith K, Keung A, Toren PC, Cheng L, Eller MG, Weir SJ. Disposition and metabolism of 14C-rifapentine in healthy volunteers. Drug Metab Dispos. 1998 Aug; 26(8):732-8. PMID: 9698286.
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    11. Emary WB, Toren PC, Mathews B, Huh K. Disposition and metabolism of rifapentine, a rifamycin antibiotic, in mice, rats, and monkeys. Drug Metab Dispos. 1998 Aug; 26(8):725-31. PMID: 9698285.
      View in: PubMed
    12. Margaret Van Heek; David Schmitt; Paul Toren; Martha K. Cathcart and Paul E. DiCorleto. Cholesteryl Hydroperoxyoctadecadienoate from Oxidized Low Density Lipoprotein Inactivates Platelet-derived Growth Factor. 1998.
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    13. Heath TG, Massad DD, Carroll JI, Mathews BS, Chang J, Scott DO, Kuo BS, Toren PC. Quantification of a dual angiotensin I-converting enzyme-neutral endopeptidase inhibitor and the active thiol metabolite in dog plasma by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Biomed Appl. 1995 Aug 04; 670(1):91-101. PMID: 7493089.
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    14. Toren P, Smith D, Chance R, Hoffman J. Determination of interchain crosslinkages in insulin B-chain dimers by fast atom bombardment mass spectrometry. Anal Biochem. 1988 Mar; 169(2):287-99. PMID: 3289414.
      View in: PubMed
    15. Hortin G, Fok KF, Toren PC, Strauss AW. Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin. J Biol Chem. 1987 Mar 05; 262(7):3082-5. PMID: 2434496.
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    16. Emary, WB; Cooks, RG; Toren, Paul. Binding of First and Subsequent Glycerol Molecules to Organic and Inorganic Cations Studied by Desolvation in the Mass Spectrometer. 1986.
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    17. Paul C. Toren; David F. Betscha; H. Lee Weitha; James M. Coulla. Analytical Biochemistry. Determination of impurities in nucleoside 3'-phosphoramidites by fast atom bombardment mass spectrometry. 1986; 152(2):291-294.
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