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Venkatesh Sampath, MBBS

TitlePhysician-Scientist
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Tamil Nadu Dr MGR Medical University, Chennai, IndiaMBBS1995
    Royal College of Physicians and Child Health Affiliated Hospitals, United KingdomResidency1998Pediatrics
    Royal Australian College of Physicians Affiliated Hospitals, AustraliaFellowship2001Neonatal Perinatal Medicine
    Cincinnati Children's Hospital Medical Center, Cincinnati, OHFellowship2006Neonatal Perinatal Medicine
    Collapse awards and honors
    1989Deptartment of Biotechnology Scholarship, Prime Minister of India
    2009 - 2019Listed to Best Doctors in America, Best Doctors, Inc. Boston, MA
    2018Golden Apple Mercy Mentor Award, Children's Mercy Hospital - Kansas City
    2018Michael B. Sheehan Mentor Award, Children's Mercy Hospital - Kansas City

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    The focus in the lab is to understand the why and the how behind neonates developing diseases, with the goal of preventing/curing them. The lab starts with disease phenotypes and study the pathogenic mechanisms underlying disease evolution to guide the development of novel future therapies. The phenotypes of interest are necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and rare infectious diseases such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). The major challenge is that diseases in neonates and premature infants occupy a unique niche, wherein, injury to the host caused by noxious stimuli such as oxygen toxicity and bacteria occur during critical ontogenic windows. Therefore, disease pathogenesis needs to be examined in the context of developmental processes to decipher mechanism and test potential therapy. The lab uses human genomic studies, rodent pre-clinical models, cell culture studies, and bioinformatics to investigate the mechanisms and sub-phenotype neonatal diseases. The long-term goal is to build an internationally renowned program in neonatal research by integrating the skill sets of a diverse team of motivated scientists and collaborators. The lab uses knowledge obtained through the investigations to develop precision tools for identifying infants at risk of disease and develop novel treatment strategies to prevent or cure disease. The three major areas of research interest are:

    I. Lung and BPD Research: Bronchopulmonary dysplasia (BPD) is a debilitating chronic lung disease in premature infants. An area of emphasis is understanding the role of lung endothelial cell (EC) injury/reprogramming in impaired lung and vascular development in BPD. To address this issue, the lab has developed new pre-clinical models of disease, and several transgenic lines to identify the key molecular players that regulate normal and abnormal vascular development. A second challenge is the inability to discern BPD sub-phenotypes, at a genomic and functional level. The lab is addressing this challenge by performing genetic and deep phenotypic characterization in BPD infants.

    II. Necrotizing Enterocolitis Research: Necrotizing enterocolitis is a major cause of mortality in premature infants, and represents phenotypes for deviant host-microbiome interactions in the gut. The lab uses forward- and reverse genetics, microbiota studies, and host-bacteria interaction studies to investigate NEC. The immediate focus of this research is the gene, Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR), which the lab identified as a putative locus for NEC susceptibility. Using novel transgenic mice that encode a NEC-associated genetic mutation the lab discovered and the lab investigated the pathogenesis of NEC. They are also testing several therapies in the pre-clinical and in vivo models.

    III. Genetic Basis of Neonatal Disease Susceptibility: The team is one of the leaders in the field of neonatal genomics. The team used low throughput-based single gene or pathway approaches, and are initiating high throughput genome-wide approaches. Apart from complex phenotypes such as BPD and NEC, they are vested in unraveling the genetic basis of rare infectious disease phenotypes such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). They are also initiating deep phenotyping and transcriptome analysis for complex phenotypes, which in combination with genetics, will help sub-classify complex phenotypes. These combined approaches can spur discovery approaches based on mechanism, as well as outcomes research based on interventions.
    Collapse research activities and funding
    2P30ES004184-22     (SAMPATH, VENKATESH)Apr 1, 2010 - Mar 31, 2012
    NIEHS
    TLRs-modulators of environmental lung injury in premature infants
    Role: Principal Investigator

    R03HD062693     (SAMPATH, VENKATESH)Jul 20, 2010 - Sep 30, 2012
    NIH
    Lipopolysaccharide-mediated oxidative stress and pulmonary vascular injury in Bro
    Role: Principal Investigator

    8KL2TR000056     (SAMPATH, VENKATESH)May 1, 2012 - Jun 30, 2015
    NIH
    Gene-environment interactions in Bronchopulmonary Dysplasia
    Role: Principal Investigator

    5P30 ES004184-25     (SAMPATH, VENKATESH)Oct 1, 2012 - Mar 31, 2014
    NIEHS
    Developmental Immunotoxicity of PAH in premature infants
    Role: Principal Investigator

    R01HL128374     (SAMPATH, VENKATESH)Aug 5, 2015 - Mar 31, 2021
    NIH
    Inflammatory Angiogenesis in the Lung
    Role: Principal Investigator

         (CUNA, ALAIN)Jan 1, 2016 - Jan 31, 2017
    Kenneth L. Smith and Eva S. Smith Clinical Scholar Award
    Role of SIGIRR and Dysbiosis in Necrotizing Enterocolitis
    Role: Primary Mentor

         (NYP, MICHAEL)Sep 1, 2017 - Aug 31, 2019
    NIH
    TRIP-1 protects against hyperoxia-mediated neonatal lung injury
    Role: Primary Mentor

         (GEORGE, LOVYA)Oct 1, 2017 - Sep 30, 2018
    CMH CRI fellow’s pilot research award
    ITGB2 immune genetic variants and NEC in premature infants
    Role: Primary Mentor

         (GEORGE, LOVYA)Nov 1, 2017 - Oct 31, 2018
    Little Giraffe Research foundation
    ITGB2 genetic variants and NEC susceptibility in premature infants
    Role: Primary Mentor

         (SAMPATH, VENKATESH)Aug 1, 2018 - Jul 30, 2019
    BioNexus-KC Patton Trust Research Foundation Grant
    SIGIRR mutations and pathogenesis of NEC in premature infants
    Role: Principle Investigator

    R01DK117296     (SAMPATH, VENKATESH)Sep 18, 2018 - Jul 31, 2023
    NIH
    Single Immunoglobulin Interleukin-1 Related Receptor and necrotizing enterocolitis in premature infants
    Role: Principal Investigator

         (CUNA, ALAIN)Oct 1, 2018 - Sep 30, 2020
    Paul Henson Foundation Award
    Role of SIGIRR and Microbiome in regulating intestinal inflammation in NEC
    Role: Primary Mentor

         (CHAVEZ-BUENO, SUSANA)Nov 1, 2018 - Oct 31, 2019
    BioNexus-KC Research Foundation Grant
    Effects of probiotics on intestinal microbiome and inflammatory response to infection by Escherichia Coli
    Role: Co-Investigator

         (CHAVEZ-BUENO, SUSANA)Oct 1, 2019 - Sep 30, 2021
    Marion Merrell Dow Award
    Single Immunoglobulin Interleukin-l Related Receptor (SIGIRR) and Escherichia coli Interactions in the Neonatal Gut
    Role: Co-Investigator

         (SALIMI, UMAR)Nov 1, 2019 - Oct 31, 2020
    Little Giraffe Research foundation
    The Role of Angiopoietins in Sepsis-Induced Neonatal Lung Injury
    Role: Primary Mentor

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ahmed I, Roy BC, Rao Jakkula LUM, Subramaniam D, Dandawate P, Anant S, Sampath V, Umar S. Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo. J Biol Chem. 2020 Jan 24; 295(4):1021-1035. PMID: 31836665.
      View in: PubMed
    2. Paul AA, Hoffman KL, Hagan JL, Sampath V, Petrosino JF, Pammi M. Fungal cutaneous microbiome and host determinants in preterm and term neonates. Pediatr Res. 2019 Dec 09. PMID: 31816621.
      View in: PubMed
    3. Kumar N, Akangire G, Sullivan B, Fairchild K, Sampath V. Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront. Pediatr Res. 2020 Jan; 87(2):210-220. PMID: 31377752.
      View in: PubMed
    4. Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 01; 317(3):L332-L346. PMID: 31268348.
      View in: PubMed
    5. Linafelter A, Cuna A, Liu C, Quigley A, Truog WE, Sampath V, Oschman A. Extended course of prednisolone in infants with severe bronchopulmonary dysplasia. Early Hum Dev. 2019 09; 136:1-6. PMID: 31265946.
      View in: PubMed
    6. Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87(2):265-276. PMID: 31086355.
      View in: PubMed
    7. Roy BC, Ahmed I, Ramalingam S, Jala V, Haribabu B, Ramamoorthy P, Ashcraft J, Valentino J, Anant S, Sampath V, Umar S. Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression. Oncotarget. 2019 Mar 22; 10(24):2340-2354. PMID: 31040926.
      View in: PubMed
    8. Warburton A, Monga R, Sampath V, Kumar N. Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants. Pediatr Res. 2019 03; 85(4):494-501. PMID: 30679791.
      View in: PubMed
    9. Ahmed I, Roy BC, Raach RT, Owens SM, Xia L, Anant S, Sampath V, Umar S. Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis. PLoS One. 2018; 13(11):e0206701. PMID: 30383855.
      View in: PubMed
    10. Cuna A, George L, Sampath V. Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions. Semin Fetal Neonatal Med. 2018 12; 23(6):387-393. PMID: 30292709.
      View in: PubMed
    11. Samanta S, Zhou Z, Rajasingh S, Panda A, Sampath V, Rajasingh J. DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling. Int J Biochem Cell Biol. 2018 09; 102:117-127. PMID: 30010012.
      View in: PubMed
    12. Xia S, Menden HL, Korfhagen TR, Kume T, Sampath V. Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling. J Physiol. 2018 04 15; 596(8):1397-1417. PMID: 29380370.
      View in: PubMed
    13. Nyp MF, Mabry SM, Navarro A, Menden H, Perez RE, Sampath V, Ekekezie II. Lung epithelial-specific TRIP-1 overexpression maintains epithelial integrity during hyperoxia exposure. Physiol Rep. 2018 03; 6(5). PMID: 29484847.
      View in: PubMed
    14. Bi G, Wu L, Huang P, Islam S, Heruth DP, Zhang LQ, Li DY, Sampath V, Huang W, Simon BA, Easley RB, Ye SQ. Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown. FASEB J. 2018 07; 32(7):3583-3596. PMID: 29452569.
      View in: PubMed
    15. Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X, Sampath V. Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. Pediatr Res. 2018 01; 83(1-1):164-174. PMID: 28846670.
      View in: PubMed
    16. Akangire G, Cuna A, Lachica C, Fischer R, Raman S, Sampath V. Neonatal Graves' Disease with Maternal Hypothyroidism. AJP Rep. 2017 Jul; 7(3):e181-e184. PMID: 28948062.
      View in: PubMed
    17. Townley N, McNellis E, Sampath V. Term Neonate with Atypical Hypoxic-Ischemic Encephalopathy Presentation: A Case Report. AJP Rep. 2017 Jul; 7(3):e171-e173. PMID: 28852582.
      View in: PubMed
    18. Sampath V, Mulrooney N, Patel AL, Cohen J, Zhang L, Garland J, Lavoie PM, Dagle J, Simpson P. A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants. Neonatology. 2017; 112(4):354-358. PMID: 28768269.
      View in: PubMed
    19. Kumar N, Monga R, Sampath V, Ehrhart B. Prospective Comparison of Enfamil and Similac Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants. Am J Perinatol. 2017 12; 34(14):1411-1416. PMID: 28637062.
      View in: PubMed
    20. Kumar N, Nandula P, Menden H, Jarzembowski J, Sampath V. Placental TLR/NLR expression signatures are altered with gestational age and inflammation. J Matern Fetal Neonatal Med. 2017 Jul; 30(13):1588-1595. PMID: 27440318.
      View in: PubMed
    21. Menden HL, Xia S, Mabry SM, Navarro A, Nyp MF, Sampath V. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. Am J Respir Cell Mol Biol. 2016 12; 55(6):767-778. PMID: 27438994.
      View in: PubMed
    22. Sampath V, Bhandari V, Berger J, Merchant D, Zhang L, Ladd M, Menden H, Garland J, Ambalavanan N, Mulrooney N, Quasney M, Dagle J, Lavoie PM, Simpson P, Dahmer M. A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. Pediatr Res. 2017 Apr; 81(4):582-588. PMID: 27893720.
      View in: PubMed
    23. Cuna A, Sampath V. Genetic alterations in necrotizing enterocolitis. Semin Perinatol. 2017 02; 41(1):61-69. PMID: 27836427.
      View in: PubMed
    24. Sampath V, Helbling D, Menden H, Dimmock D, Mulrooney NP, Murray JC, Dagle JM, Garland JS. Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants. J Pediatr Gastroenterol Nutr. 2016 Mar; 62(3):420-3. PMID: 26426434.
      View in: PubMed
    25. Garvin J, Sampath V, Karody VR. Gastroschisis Complicated by Septo-Optic Dysplasia: Two Distinct Anomalies with a Common Origin. AJP Rep. 2016 Mar; 6(1):e15-7. PMID: 26929863.
      View in: PubMed
    26. Karody V, Reese S, Kumar N, Liedel J, Jarzembowski J, Sampath V. A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. J Matern Fetal Neonatal Med. 2016; 29(13):2210-6. PMID: 26371589.
      View in: PubMed
    27. Sampath V, Menden H, Helbling D, Li K, Gastonguay A, Ramchandran R, Dimmock DP. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics. 2015 Jun; 135(6):e1530-4. PMID: 25963006.
      View in: PubMed
    28. Li K, Chowdhury T, Vakeel P, Koceja C, Sampath V, Ramchandran R. Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts. Vasc Cell. 2015; 7:3. PMID: 25914805.
      View in: PubMed
    29. Menden H, Welak S, Cossette S, Ramchandran R, Sampath V. Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. J Biol Chem. 2015 Feb 27; 290(9):5449-61. PMID: 25568324.
      View in: PubMed
    30. Sampath V, Garland JS, Helbling D, Dimmock D, Mulrooney NP, Simpson PM, Murray JC, Dagle JM. Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants. Pediatr Res. 2015 Mar; 77(3):477-83. PMID: 25518008.
      View in: PubMed
    31. Sampath V, Ruby Gupta. Intrauterine fetal monitoring. Indian Journal of Practical Pediatrics. 2014; 3(16):227-232.
    32. Sampath V. Translational Research – It Takes Two to Tango!. MOJ Cell Sci Report. 2014; 1(1):6-7.
    33. Sampath V, Mulrooney NP, Garland JS, He J, Patel AL, Cohen JD, Simpson PM, Hines RN. Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants. J Perinatol. 2013 Oct; 33(10):772-7. PMID: 23867959.
      View in: PubMed
    34. Menden H, Tate E, Hogg N, Sampath V. LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-ß phosphorylation. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15; 304(6):L445-55. PMID: 23333803.
      View in: PubMed
    35. Karody VR, Le M, Nelson S, Meskin K, Klemm S, Simpson P, Hines R, Sampath V. A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth. J Perinatol. 2013 May; 33(5):341-6. PMID: 23047423.
      View in: PubMed
    36. Kumar N, Leverence J, Bick D, Sampath V. Ontogeny of growth-regulating genes in the placenta. Placenta. 2012 Feb; 33(2):94-9. PMID: 22154689.
      View in: PubMed
    37. Sampath V, Garland JS, Le M, Patel AL, Konduri GG, Cohen JD, Simpson PM, Hines RN. A TLR5 (g.1174C?>?T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia. Pediatr Pulmonol. 2012 May; 47(5):460-8. PMID: 22058078.
      View in: PubMed
    38. Sampath V, Le M, Lane L, Patel AL, Cohen JD, Simpson PM, Garland JS, Hines RN. The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants. J Surg Res. 2011 Jul; 169(1):e51-7. PMID: 21529841.
      View in: PubMed
    39. Leverence JT, Medhora M, Konduri GG, Sampath V. Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKC?-mediated p47phox phosphorylation. Chem Biol Interact. 2011 Jan 15; 189(1-2):72-81. PMID: 20920494.
      View in: PubMed
    40. Sampath V, Radish AC, Eis AL, Broniowska K, Hogg N, Konduri GG. Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia. Free Radic Biol Med. 2009 Mar 01; 46(5):663-71. PMID: 19135525.
      View in: PubMed
    41. Sampath V, Davis K, Senft AP, Richardson TR, Kitzmiller JA, Berclaz PY, Korfhagen TR. Altered postnatal lung development in C3H/HeJ mice. Pediatr Res. 2006 Dec; 60(6):663-8. PMID: 17065580.
      View in: PubMed
    42. Sampath V. Neonatal Necrotizing enter colitis - the continuing saga. Indian Journal of Practical Pediatrics. 2006.
    43. Sampath V. The Fetal Origins Hypothesis - implications for the 21st century. Indian Journal of Practical Pediatrics. 2005; 4(7):273.
    44. Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep; 25(9):608-11. PMID: 16123790.
      View in: PubMed
    45. Sampath V, Bowen J, Gibson F. Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound. J Perinatol. 2005 Mar; 25(3):210-5. PMID: 15578032.
      View in: PubMed
    46. Pillai B, Sampath V, Sharma N, Sadhale P. Rpb4, a non-essential subunit of core RNA polymerase II of Saccharomyces cerevisiae is important for activated transcription of a subset of genes. J Biol Chem. 2001 Aug 17; 276(33):30641-7. PMID: 11382749.
      View in: PubMed
    47. Sampath V, Zhao XJ, Caughey WS. Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function. J Biol Chem. 2001 Apr 27; 276(17):13635-43. PMID: 11278308.
      View in: PubMed
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