Venkatesh Sampath, MBBS, MRCPCH
Title | Physician-Scientist |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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vCard | Download vCard |
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Title | Sosland Chair in Neonatal Research |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Title | Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Title | Research Associate Professor of Pediatrics |
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Institution | University of Kansas Medical Center |
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Department | Pediatrics |
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Biography Tamil Nadu Dr MGR Medical University, Chennai, India | MBBS | 1995 | | Royal College of Physicians and Child Health Affiliated Hospitals, United Kingdom | Residency | 1998 | Pediatrics | Royal Australian College of Physicians Affiliated Hospitals, Australia | Fellowship | 2001 | Neonatal Perinatal Medicine | Cincinnati Children's Hospital Medical Center, Cincinnati, OH | Fellowship | 2006 | Neonatal Perinatal Medicine |
1989 | Department of Biotechnology Scholarship, Prime Minister of India | 2009 - 2019 | Listed to Best Doctors in America, Best Doctors, Inc. Boston, MA | 2018 | Golden Apple Mercy Mentor Award, Children's Mercy Hospital - Kansas City | 2018 | Michael B. Sheehan Mentor Award, Children's Mercy Hospital - Kansas City | 2021 | Research Achievement Award, Children's Mercy Hospital - Kansas City | 2021 | Sosland Endowed Chair in Neonatal Research, Children's Mercy Hospital - Kansas City | 2021 | Clinical Care Team Achievement Award; BPD Multidisciplinary Team , Children's Mercy Hospital - Kansas City | 2022 | Michael B. Sheehan Mentor Award, Children's Mercy Hospital - Kansas City | 2023 - 2023 | Golden Apple Mercy Mentor Award, Children's Mercy Hospital-Kansas City |
Overview Research The focus in the lab is to understand the why and the how behind neonates developing diseases, with the goal of preventing/curing them. The lab starts with disease phenotypes and study the pathogenic mechanisms underlying disease evolution to guide the development of novel future therapies. The phenotypes of interest are necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and rare infectious diseases such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). The major challenge is that diseases in neonates and premature infants occupy a unique niche, wherein, injury to the host caused by noxious stimuli such as oxygen toxicity and bacteria occur during critical ontogenic windows. Therefore, disease pathogenesis needs to be examined in the context of developmental processes to decipher mechanism and test potential therapy. The lab uses human genomic studies, rodent pre-clinical models, cell culture studies, and bioinformatics to investigate the mechanisms and sub-phenotype neonatal diseases. The long-term goal is to build an internationally renowned program in neonatal research by integrating the skill sets of a diverse team of motivated scientists and collaborators. The lab uses knowledge obtained through the investigations to develop precision tools for identifying infants at risk of disease and develop novel treatment strategies to prevent or cure disease. The three major areas of research interest are:
I. Lung and BPD Research: Bronchopulmonary dysplasia (BPD) is a debilitating chronic lung disease in premature infants. An area of emphasis is understanding the role of lung endothelial cell (EC) injury/reprogramming in impaired lung and vascular development in BPD. To address this issue, the lab has developed new pre-clinical models of disease, and several transgenic lines to identify the key molecular players that regulate normal and abnormal vascular development. A second challenge is the inability to discern BPD sub-phenotypes, at a genomic and functional level. The lab is addressing this challenge by performing genetic and deep phenotypic characterization in BPD infants.
II. Necrotizing Enterocolitis Research: Necrotizing enterocolitis is a major cause of mortality in premature infants, and represents phenotypes for deviant host-microbiome interactions in the gut. The lab uses forward- and reverse genetics, microbiota studies, and host-bacteria interaction studies to investigate NEC. The immediate focus of this research is the gene, Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR), which the lab identified as a putative locus for NEC susceptibility. Using novel transgenic mice that encode a NEC-associated genetic mutation the lab discovered and the lab investigated the pathogenesis of NEC. They are also testing several therapies in the pre-clinical and in vivo models.
III. Genetic Basis of Neonatal Disease Susceptibility: The team is one of the leaders in the field of neonatal genomics. The team used low throughput-based single gene or pathway approaches, and are initiating high throughput genome-wide approaches. Apart from complex phenotypes such as BPD and NEC, they are vested in unraveling the genetic basis of rare infectious disease phenotypes such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). They are also initiating deep phenotyping and transcriptome analysis for complex phenotypes, which in combination with genetics, will help sub-classify complex phenotypes. These combined approaches can spur discovery approaches based on mechanism, as well as outcomes research based on interventions.
2P30ES004184-22 (SAMPATH, VENKATESH)Apr 1, 2010 - Mar 31, 2012 NIEHS TLRs-modulators of environmental lung injury in premature infants Role: Principal Investigator |
| R03HD062693 (SAMPATH, VENKATESH)Jul 20, 2010 - Sep 30, 2012 NIH Lipopolysaccharide-mediated oxidative stress and pulmonary vascular injury in Bro Role: Principal Investigator |
| 8KL2TR000056 (SAMPATH, VENKATESH)May 1, 2012 - Jun 30, 2015 NIH Gene-environment interactions in Bronchopulmonary Dysplasia Role: Principal Investigator |
| 5P30 ES004184-25 (SAMPATH, VENKATESH)Oct 1, 2012 - Mar 31, 2014 NIEHS Developmental Immunotoxicity of PAH in premature infants Role: Principal Investigator |
| R01HL128374 (SAMPATH, VENKATESH)Aug 5, 2015 - Mar 31, 2021 NIH Inflammatory Angiogenesis in the Lung Role: Principal Investigator |
| (CUNA, ALAIN)Jan 1, 2016 - Jan 31, 2017 Kenneth L. Smith and Eva S. Smith Clinical Scholar Award Role of SIGIRR and Dysbiosis in Necrotizing Enterocolitis Role: Primary Mentor |
| (NYP, MICHAEL)Sep 1, 2017 - Aug 31, 2019 NIH TRIP-1 protects against hyperoxia-mediated neonatal lung injury Role: Primary Mentor |
| (GEORGE, LOVYA)Oct 1, 2017 - Sep 30, 2018 CMH CRI fellow’s pilot research award ITGB2 immune genetic variants and NEC in premature infants Role: Primary Mentor |
| (GEORGE, LOVYA)Nov 1, 2017 - Oct 31, 2018 Little Giraffe Research foundation ITGB2 genetic variants and NEC susceptibility in premature infants Role: Primary Mentor |
| (SAMPATH, VENKATESH)Aug 1, 2018 - Jul 30, 2019 BioNexus-KC Patton Trust Research Foundation Grant SIGIRR mutations and pathogenesis of NEC in premature infants Role: Principle Investigator |
| R01DK117296 (SAMPATH, VENKATESH)Sep 18, 2018 - Jul 31, 2023 NIH Single Immunoglobulin Interleukin-1 Related Receptor and necrotizing enterocolitis in premature infants Role: Principal Investigator |
| (CUNA, ALAIN)Oct 1, 2018 - Sep 30, 2020 Paul Henson Foundation Award Role of SIGIRR and Microbiome in regulating intestinal inflammation in NEC Role: Primary Mentor |
| (CHAVEZ-BUENO, SUSANA)Nov 1, 2018 - Oct 31, 2019 BioNexus-KC Research Foundation Grant Effects of probiotics on intestinal microbiome and inflammatory response to infection by Escherichia Coli Role: Co-Investigator |
| (CHAVEZ-BUENO, SUSANA)Oct 1, 2019 - Sep 30, 2022 Marion Merrell Dow Award Single Immunoglobulin Interleukin-l Related Receptor (SIGIRR) and Escherichia coli Interactions in the Neonatal Gut Role: Co-Investigator |
| (SALIMI, UMAR)Nov 1, 2019 - Oct 31, 2020 Little Giraffe Research foundation The Role of Angiopoietins in Sepsis-Induced Neonatal Lung Injury Role: Primary Mentor |
| 1R01HD097578-01 (MOROWITZ, MICHAEL)Nov 1, 2019 - Sep 30, 2024 NICHD The NICU Antibiotics and Neonatal Outcomes (NANO) trial Role Description: The goal of the NANO trial is to study the longstanding clinical practice of empirically administering intravenous antibiotics to extremely low birthweight (ELBW) infants in the first days of life. Role: Co-Investigator |
| (MOROWITZ, MICHAEL)Jan 1, 2020 - Jun 30, 2022 March of Dimes Genetic and microbial risk factors for adverse outcomes in the NANO trial Role: Co-Principal Investigator |
| R01HD104215 (DEFRANCO, DONALD B)Sep 1, 2021 - Jun 30, 2026 NIH A Safer Glucocorticoid to Treat Neonatal Lung Injury with Limited Adverse Neurologic Effects Role: Co-Investigator |
| R01HL162937 (Venkatesh Sampath)Jan 16, 2023 National Heart, Lung @ Blood Institute DLL4 in the Developing Lung and Bronchopulmonary Dysplasia (BPD_ Role Description: Study of how delta like 4 (DLL4), a molecule expressed in endothelial cells, regulates blood vessel and air sac formation during normal and abnormal (bronchopulmonary dysplasia) lung development and may help identify new therapies for BPD. Role: Principal Investigator |
Bibliography
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Tucker MH, Yu W, Menden H, Xia S, Schreck CF, Gibson M, Louiselle D, Pastinen T, Raje N, Sampath V. IRF7 and UNC93B1 variants in an infant with recurrent herpes simplex virus infection. J Clin Invest. 2023 06 01; 133(11). PMID: 37097753.
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Cuna A, Nsumu M, Menden HL, Chavez-Bueno S, Sampath V. The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated with Lactobacillus rhamnosus GG. Microorganisms. 2023 Jun 01; 11(6). PMID: 37374984.
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Tan C, Norden PR, Yu W, Liu T, Ujiie N, Lee SK, Yan X, Dyakiv Y, Aoto K, Ortega S, De Plaen IG, Sampath V, Kume T. Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury. EMBO Rep. 2023 Jul 05; 24(7):e56030. PMID: 37154714.
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Menden HL, Mabry SM, Venkatraman A, Xia S, DeFranco DB, Yu W, Sampath V. The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide. Am J Physiol Lung Cell Mol Physiol. 2023 05 01; 324(5):L722-L736. PMID: 36976925.
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Sampath V, Martinez M, Caplan M, Underwood MA, Cuna A. Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies. Mucosal Immunol. 2023 04; 16(2):208-220. PMID: 36804483.
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Cuna A, Morowitz MJ, Sampath V. Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review. Front Pediatr. 2023; 11:1112812. PMID: 36865691.
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Yusuf K, Sampath V, Umar S. Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients. Int J Mol Sci. 2023 Feb 04; 24(4). PMID: 36834525.
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Xia S, Vila Ellis L, Winkley K, Menden H, Mabry SM, Venkatraman A, Louiselle D, Gibson M, Grundberg E, Chen J, Sampath V. Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2023 02 01; 324(2):L123-L140. PMID: 36537711.
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Akangire G, Lachica C, Noel-MacDonnell J, Begley A, Sampath V, Truog W, Manimtim W. Outcomes of infants with severe bronchopulmonary dysplasia who received tracheostomy and home ventilation. Pediatr Pulmonol. 2023 03; 58(3):753-762. PMID: 36377273.
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Yu W, Venkatraman A, Menden HL, Martinez M, Umar S, Sampath V. Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction. Am J Physiol Gastrointest Liver Physiol. 2023 01 01; 324(1):G24-G37. PMID: 36410023.
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Ke X, Huang Y, Fu Q, Majnik A, Sampath V, Lane RH. Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus. Anat Rec (Hoboken). 2023 01; 306(1):162-175. PMID: 35983908.
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Tucker MH, Yeh HW, Oh D, Shaw N, Kumar N, Sampath V. Preterm sepsis is associated with acute lung injury as measured by pulmonary severity score. Pediatr Res. 2023 03; 93(4):1050-1056. PMID: 35906303.
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Rao K, Cuna A, Chavez-Bueno S, Menden H, Yu W, Ahmed I, Srinivasan P, Umar S, Sampath V. Effect of Various Preterm Infant Milk Formulas on NEC-Like Gut Injury in Mice. Front Pediatr. 2022; 10:902798. PMID: 35874567.
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Khashu M, Dame C, Lavoie PM, De Plaen IG, Garg PM, Sampath V, Malhotra A, Caplan MD, Kumar P, Agrawal PB, Buonocore G, Christensen RD, Maheshwari A. Current Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence. Newborn (Clarksville). 2022 Jan-Mar; 1(1):201-208. PMID: 35746957.
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Cohen ASA, Farrow EG, Abdelmoity AT, Alaimo JT, Amudhavalli SM, Anderson JT, Bansal L, Bartik L, Baybayan P, Belden B, Berrios CD, Biswell RL, Buczkowicz P, Buske O, Chakraborty S, Cheung WA, Coffman KA, Cooper AM, Cross LA, Curran T, Dang TTT, Elfrink MM, Engleman KL, Fecske ED, Fieser C, Fitzgerald K, Fleming EA, Gadea RN, Gannon JL, Gelineau-Morel RN, Gibson M, Goldstein J, Grundberg E, Halpin K, Harvey BS, Heese BA, Hein W, Herd SM, Hughes SS, Ilyas M, Jacobson J, Jenkins JL, Jiang S, Johnston JJ, Keeler K, Korlach J, Kussmann J, Lambert C, Lawson C, Le Pichon JB, Leeder JS, Little VC, Louiselle DA, Lypka M, McDonald BD, Miller N, Modrcin A, Nair A, Neal SH, Oermann CM, Pacicca DM, Pawar K, Posey NL, Price N, Puckett LMB, Quezada JF, Raje N, Rowell WJ, Rush ET, Sampath V, Saunders CJ, Schwager C, Schwend RM, Shaffer E, Smail C, Soden S, Strenk ME, Sullivan BR, Sweeney BR, Tam-Williams JB, Walter AM, Welsh H, Wenger AM, Willig LK, Yan Y, Younger ST, Zhou D, Zion TN, Thiffault I, Pastinen T. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genet Med. 2022 06; 24(6):1336-1348. PMID: 35305867.
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Akangire G, Menden H, Xia S, Thiffault I, Ahmed A, Sampath V. EPHB4 Mutation Suppresses PROX1 Expression and Disrupts Lymphatic Development in Neonatal Hydrops. Pediatrics. 2022 03 01; 149(3). PMID: 35178555.
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Salimi U, Dummula K, Tucker MH, Dela Cruz CS, Sampath V. Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into "New BPD". Am J Respir Cell Mol Biol. 2022 02; 66(2):137-145. PMID: 34644520.
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Ahmed I, Yusuf K, Roy BC, Stubbs J, Anant S, Attard TM, Sampath V, Umar S. Dietary Interventions Ameliorate Infectious Colitis by Restoring the Microbiome and Promoting Stem Cell Proliferation in Mice. Int J Mol Sci. 2021 Dec 29; 23(1). PMID: 35008767.
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Yu W, Haque I, Venkatraman A, Menden HL, Mabry SM, Roy BC, Xia S, Prokop JW, Umar S, Geurts AM, Sampath V. SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. Cell Mol Gastroenterol Hepatol. 2022; 13(2):425-440. PMID: 34563711.
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Roy BC, Ahmed I, Stubbs J, Zhang J, Attard T, Septer S, Welch D, Anant S, Sampath V, Umar S. Correction: DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis. Cell Death Discov. 2021 Aug 02; 7(1):200. PMID: 34341333.
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Sampath V, Ramchandran R. The Yin and the Yang of Transformative Research During the COVID-19 Pandemic-A Perspective. Front Pediatr. 2021; 9:650302. PMID: 34249804.
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Roy BC, Ahmed I, Stubbs J, Zhang J, Attard T, Septer S, Welch D, Anant S, Sampath V, Umar S. DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis. Cell Death Discov. 2021 Jun 17; 7(1):169. PMID: 34226497.
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Jaumotte JD, Franks AL, Bargerstock EM, Kisanga EP, Menden HL, Ghersi A, Omar M, Wang L, Rudine A, Short KL, Silswal N, Cole TJ, Sampath V, Monaghan-Nichols AP, DeFranco DB. Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum. Neurobiol Dis. 2021 08; 156:105422. PMID: 34126164.
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Salimi U, Menden HL, Mabry SM, Xia S, Sampath V. Angiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice. Pediatr Res. 2022 05; 91(6):1405-1415. PMID: 33980990.
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Xia S, Yu W, Menden H, Younger ST, Sampath V. FOXC2 Autoregulates Its Expression in the Pulmonary Endothelium After Endotoxin Stimulation in a Histone Acetylation-Dependent Manner. Front Cell Dev Biol. 2021; 9:657662. PMID: 34017833.
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Xia S, Menden HL, Townley N, Mabry SM, Johnston J, Nyp MF, Heruth DP, Korfhagen T, Sampath V. Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung. JCI Insight. 2021 04 08; 6(7). PMID: 33830085.
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Cuna A, Sampath V, Khashu M. Racial Disparities in Necrotizing Enterocolitis. Front Pediatr. 2021; 9:633088. PMID: 33681105.
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Venkatraman A, Yu W, Nitkin C, Sampath V. Intestinal Stem Cell Development in the Neonatal Gut: Pathways Regulating Development and Relevance to Necrotizing Enterocolitis. Cells. 2021 02 03; 10(2). PMID: 33546361.
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George L, Menden H, Xia S, Yu W, Holmes A, Johnston J, Reid KJ, Josephson CD, Patel RM, Ahmed A, Mulrooney N, Miller NA, Farrow E, Sampath V. ITGB2 (Integrin ?2) Immunomodulatory Gene Variants in Premature Infants With Necrotizing Enterocolitis. J Pediatr Gastroenterol Nutr. 2021 02 01; 72(2):e37-e41. PMID: 32925548.
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Cuna A, Morowitz MJ, Ahmed I, Umar S, Sampath V. Dynamics of the preterm gut microbiome in health and disease. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G411-G419. PMID: 33439103.
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Cummings L, Tucker M, Gibson M, Myers A, Pastinen T, Johnston J, Farrow E, Sampath V. Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections. Pediatrics. 2021 01; 147(1). PMID: 33386334.
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Akangire G, Taylor JB, McAnany S, Noel-MacDonnell J, Lachica C, Sampath V, Manimtim W. Respiratory, growth, and survival outcomes of infants with tracheostomy and ventilator dependence. Pediatr Res. 2021 08; 90(2):381-389. PMID: 33010793.
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Kumar N, Kumar P, Harris N, Monga R, Sampath V. Impact of Maternal HbA1c Levels =6% and Race in Nondiabetic Pregnancies on Birthweight and Early Neonatal Hypoglycemia. J Pediatr. 2020 12; 227:121-127.e3. PMID: 32800816.
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Nitkin CR, Xia S, Menden H, Yu W, Xiong M, Heruth DP, Ye SQ, Sampath V. FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling. Sci Rep. 2020 08 04; 10(1):13143. PMID: 32753701.
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Kim JH, Sampath V, Canvasser J. Challenges in diagnosing necrotizing enterocolitis. Pediatr Res. 2020 08; 88(Suppl 1):16-20. PMID: 32855507.
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Cuna A, Yu W, Menden HL, Feng L, Srinivasan P, Chavez-Bueno S, Ahmed I, Umar S, Sampath V. NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice. Pediatr Res. 2020 10; 88(4):546-555. PMID: 32053825.
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Ahmed I, Roy BC, Rao Jakkula LUM, Subramaniam D, Dandawate P, Anant S, Sampath V, Umar S. Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo. J Biol Chem. 2020 01 24; 295(4):1021-1035. PMID: 31836665.
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Paul AA, Hoffman KL, Hagan JL, Sampath V, Petrosino JF, Pammi M. Fungal cutaneous microbiome and host determinants in preterm and term neonates. Pediatr Res. 2020 08; 88(2):225-233. PMID: 31816621.
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Kumar N, Akangire G, Sullivan B, Fairchild K, Sampath V. Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront. Pediatr Res. 2020 01; 87(2):210-220. PMID: 31377752.
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Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2019 09 01; 317(3):L332-L346. PMID: 31268348.
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Linafelter A, Cuna A, Liu C, Quigley A, Truog WE, Sampath V, Oschman A. Extended course of prednisolone in infants with severe bronchopulmonary dysplasia. Early Hum Dev. 2019 09; 136:1-6. PMID: 31265946.
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Nitkin CR, Rajasingh J, Pisano C, Besner GE, Th?baud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 01; 87(2):265-276. PMID: 31086355.
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Roy BC, Ahmed I, Ramalingam S, Jala V, Haribabu B, Ramamoorthy P, Ashcraft J, Valentino J, Anant S, Sampath V, Umar S. Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression. Oncotarget. 2019 Mar 22; 10(24):2340-2354. PMID: 31040926.
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Warburton A, Monga R, Sampath V, Kumar N. Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants. Pediatr Res. 2019 03; 85(4):494-501. PMID: 30679791.
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Ahmed I, Roy BC, Raach RT, Owens SM, Xia L, Anant S, Sampath V, Umar S. Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis. PLoS One. 2018; 13(11):e0206701. PMID: 30383855.
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Cuna A, George L, Sampath V. Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions. Semin Fetal Neonatal Med. 2018 12; 23(6):387-393. PMID: 30292709.
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Samanta S, Zhou Z, Rajasingh S, Panda A, Sampath V, Rajasingh J. DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling. Int J Biochem Cell Biol. 2018 09; 102:117-127. PMID: 30010012.
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Xia S, Menden HL, Korfhagen TR, Kume T, Sampath V. Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling. J Physiol. 2018 04 15; 596(8):1397-1417. PMID: 29380370.
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Nyp MF, Mabry SM, Navarro A, Menden H, Perez RE, Sampath V, Ekekezie II. Lung epithelial-specific TRIP-1 overexpression maintains epithelial integrity during hyperoxia exposure. Physiol Rep. 2018 03; 6(5). PMID: 29484847.
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Bi G, Wu L, Huang P, Islam S, Heruth DP, Zhang LQ, Li DY, Sampath V, Huang W, Simon BA, Easley RB, Ye SQ. Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown. FASEB J. 2018 07; 32(7):3583-3596. PMID: 29452569.
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Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X, Sampath V. Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. Pediatr Res. 2018 01; 83(1-1):164-174. PMID: 28846670.
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Sifers, TM and Sampath V. . Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods In Immune Support" Eds S. Chatterjee, W. Jungriathmyr and D. Bagchi. Monogenic defects of Toll-Like Receptor signaling and primary immunodeficiency. 2017.
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Akangire G, Cuna A, Lachica C, Fischer R, Raman S, Sampath V. Neonatal Graves' Disease with Maternal Hypothyroidism. AJP Rep. 2017 Jul; 7(3):e181-e184. PMID: 28948062.
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Townley N, McNellis E, Sampath V. Term Neonate with Atypical Hypoxic-Ischemic Encephalopathy Presentation: A Case Report. AJP Rep. 2017 Jul; 7(3):e171-e173. PMID: 28852582.
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Sampath V, Mulrooney N, Patel AL, Cohen J, Zhang L, Garland J, Lavoie PM, Dagle J, Simpson P. A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants. Neonatology. 2017; 112(4):354-358. PMID: 28768269.
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Kumar N, Monga R, Sampath V, Ehrhart B. Prospective Comparison of Enfamil and Similac Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants. Am J Perinatol. 2017 12; 34(14):1411-1416. PMID: 28637062.
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Kumar N, Nandula P, Menden H, Jarzembowski J, Sampath V. Placental TLR/NLR expression signatures are altered with gestational age and inflammation. J Matern Fetal Neonatal Med. 2017 Jul; 30(13):1588-1595. PMID: 27440318.
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Menden HL, Xia S, Mabry SM, Navarro A, Nyp MF, Sampath V. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. Am J Respir Cell Mol Biol. 2016 12; 55(6):767-778. PMID: 27438994.
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Sampath V, Bhandari V, Berger J, Merchant D, Zhang L, Ladd M, Menden H, Garland J, Ambalavanan N, Mulrooney N, Quasney M, Dagle J, Lavoie PM, Simpson P, Dahmer M. A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. Pediatr Res. 2017 Apr; 81(4):582-588. PMID: 27893720.
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Cuna A, Sampath V. Genetic alterations in necrotizing enterocolitis. Semin Perinatol. 2017 02; 41(1):61-69. PMID: 27836427.
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Sampath V, Helbling D, Menden H, Dimmock D, Mulrooney NP, Murray JC, Dagle JM, Garland JS. Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants. J Pediatr Gastroenterol Nutr. 2016 Mar; 62(3):420-3. PMID: 26426434.
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Garvin J, Sampath V, Karody VR. Gastroschisis Complicated by Septo-Optic Dysplasia: Two Distinct Anomalies with a Common Origin. AJP Rep. 2016 Mar; 6(1):e15-7. PMID: 26929863.
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Karody V, Reese S, Kumar N, Liedel J, Jarzembowski J, Sampath V. A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. J Matern Fetal Neonatal Med. 2016; 29(13):2210-6. PMID: 26371589.
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Sampath V, Menden H, Helbling D, Li K, Gastonguay A, Ramchandran R, Dimmock DP. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics. 2015 Jun; 135(6):e1530-4. PMID: 25963006.
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Li K, Chowdhury T, Vakeel P, Koceja C, Sampath V, Ramchandran R. Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts. Vasc Cell. 2015; 7:3. PMID: 25914805.
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Menden H, Welak S, Cossette S, Ramchandran R, Sampath V. Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. J Biol Chem. 2015 Feb 27; 290(9):5449-61. PMID: 25568324.
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Sampath V, Garland JS, Helbling D, Dimmock D, Mulrooney NP, Simpson PM, Murray JC, Dagle JM. Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants. Pediatr Res. 2015 Mar; 77(3):477-83. PMID: 25518008.
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Sampath V, Ruby Gupta. Intrauterine fetal monitoring. Indian Journal of Practical Pediatrics. 2014; 3(16):227-232.
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Sampath V. Translational Research – It Takes Two to Tango!. MOJ Cell Sci Report. 2014; 1(1):6-7.
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Menden H, Tate E, Hogg N, Sampath V. LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-? phosphorylation. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15; 304(6):L445-55. PMID: 23333803.
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Sampath V, Garland JS, Le M, Patel AL, Konduri GG, Cohen JD, Simpson PM, Hines RN. A TLR5 (g.1174C?>?T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia. Pediatr Pulmonol. 2012 May; 47(5):460-8. PMID: 22058078.
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Sampath V, Le M, Lane L, Patel AL, Cohen JD, Simpson PM, Garland JS, Hines RN. The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants. J Surg Res. 2011 Jul; 169(1):e51-7. PMID: 21529841.
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Leverence JT, Medhora M, Konduri GG, Sampath V. Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKC?-mediated p47phox phosphorylation. Chem Biol Interact. 2011 Jan 15; 189(1-2):72-81. PMID: 20920494.
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Sampath V, Radish AC, Eis AL, Broniowska K, Hogg N, Konduri GG. Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia. Free Radic Biol Med. 2009 Mar 01; 46(5):663-71. PMID: 19135525.
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Sampath V, Davis K, Senft AP, Richardson TR, Kitzmiller JA, Berclaz PY, Korfhagen TR. Altered postnatal lung development in C3H/HeJ mice. Pediatr Res. 2006 Dec; 60(6):663-8. PMID: 17065580.
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Sampath V. Neonatal Necrotizing enter colitis - the continuing saga. Indian Journal of Practical Pediatrics. 2006.
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Sampath V. The Fetal Origins Hypothesis - implications for the 21st century. Indian Journal of Practical Pediatrics. 2005; 4(7):273.
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Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep; 25(9):608-11. PMID: 16123790.
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Sampath V, Bowen J, Gibson F. Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound. J Perinatol. 2005 Mar; 25(3):210-5. PMID: 15578032.
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Year | Publications |
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2005 | 3 | 2006 | 2 | 2008 | 1 | 2010 | 1 | 2011 | 2 | 2013 | 1 | 2014 | 3 | 2015 | 5 | 2016 | 4 | 2017 | 7 | 2018 | 6 | 2019 | 8 | 2020 | 6 | 2021 | 13 | 2022 | 10 | 2023 | 7 |
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