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Last Name
Institution

Mark Hoffman, PhD

TitleChief Research Information Officer
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentBiomedical and Health Informatics

    TitleProfessor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics

    TitleAssociate Member
    InstitutionUniversity of Kansas Medical Center
    DepartmentCancer Center, Cancer Prevention and Control


    Collapse Biography 
    Collapse education and training
    University of Wisconsin - Madison, Madison, WIPhD1996Bacteriology
    William Jewell, Liberty, MOBachelor of Arts05/1991Molecular Biology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Hoffman serves as the Chief Research Information officer for Children’s Mercy Hospital (CMH) and the Children’s Research Institute. His current research focuses on the use of a large, de-identified, data set of electronic health record information for digital phenotyping. He serves as co-PI for the Informatics Core of the Frontiers CTSA. Dr. Hoffman has delivered a TEDx talk on the “Envirome”. He is an inventor on 24 issued patents and a member of the American Academy of Inventors. Prior to CMH, he served as VP for Research and Genomics at Cerner, where he led initiatives in public health and “big data".
    Collapse research activities and funding
    NU47OE000105     (HOFFMAN, MARK A.)Sep 1, 2016 - Jan 31, 2019
    CDC
    Local quality improvement informed by a national warehouse of practice-based evidence
    Role: PI
    R24GM123930     (GAEDIGK, ANDREA)Aug 1, 2017 - Jul 31, 2020
    NIH
    PHARMacogene VARiation Consortium
    Role: Co-Investigator
    UL1TR002366     (BAROHN, RICHARD J.)Sep 7, 2017 - Jun 30, 2022
    NIH
    Frontiers: University of Kansas Clinical and Translational Science Institute
    Role: Co-Investigator
         (Hoffman, Mark)Oct 1, 2018 - Sep 30, 2020
    Masonic Cancer Alliance
    Modeling pediatric cancer trajectories using de-identified EHR data
    Role: PI
    H98MC33239-01-00     (Abdelmoity, Ahmed)Sep 1, 2019 - Aug 31, 2022
    HRSA
    Reaching out for Epilepsy in Adolescents and Children through Telemedicine (REACT)
    Role: Co-Investigator
    R01MD015409     (GRUNDBERG, ELIN)Aug 26, 2020 - Apr 30, 2025
    NIH
    Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
    Role: Co-Investigator
    R01AI176770     (Mark Hoffman)Jul 1, 2023 - Jun 30, 2028
    National Institute of Allergy and Infectious Disease
    Using massive, multi-regional EHR data to estimate the impacts of climate change on fungal disease epidemiology in the U.S.
    Role: PI

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Feldman K, Kane NJ, Daniels-Young S, Reed B, Welch J, Fitzpatrick L, Hoffman MA, Bradley-Ewing A, Grundberg E. Utilization of geospatial distribution in the measurement of study cohort representativeness. J Biomed Inform. 2024 Jul 08; 157:104687. PMID: 38986921.
      View in: PubMed
    2. Scierka LE, Bradley BA, Glynn E, Davis S, Hoffman M, Tam-Williams JB, Mena-Hurtado C, Smolderen KG. Chronic Cough: Characterizing and Quantifying Burden in Adults Using a Nationwide Electronic Health Records Database. J Healthc Inform Res. 2024 Mar; 8(1):50-64. PMID: 38273985.
      View in: PubMed
    3. Kane NJ, Cohen ASA, Berrios C, Jones B, Pastinen T, Hoffman MA. Committing to genomic answers for all kids: Evaluating inequity in genomic research enrollment. Genet Med. 2023 09; 25(9):100895. PMID: 37194653.
      View in: PubMed
    4. Sivasankar S, Goldman JL, Hoffman MA. Variation in antibiotic resistance patterns for children and adults treated at 166 non-affiliated US facilities using EHR data. JAC Antimicrob Resist. 2023 Feb; 5(1):dlac128. PMID: 36601546.
      View in: PubMed
    5. Le Pichon JB, Horton S, Abdelmoity O, Hoffman MA, Cramer E, Kishk N, Hamada S, Abdelmoity A. The use of virtual tools in narrowing the impact of health disparities in neurology. Front Pediatr. 2022; 10:1028833. PMID: 36313873.
      View in: PubMed
    6. Wiley K, Findley L, Goldrich M, Rakhra-Burris TK, Stevens A, Williams P, Bult CJ, Chisholm R, Deverka P, Ginsburg GS, Green ED, Jarvik G, Mensah GA, Ramos E, Relling MV, Roden DM, Rowley R, Alterovitz G, Aronson S, Bastarache L, Cimino JJ, Crowgey EL, Del Fiol G, Freimuth RR, Hoffman MA, Jeff J, Johnson K, Kawamoto K, Madhavan S, Mendonca EA, Ohno-Machado L, Pratap S, Taylor CO, Ritchie MD, Walton N, Weng C, Zayas-Cab?n T, Manolio TA, Williams MS. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc. 2022 07 12; 29(8):1342-1349. PMID: 35485600.
      View in: PubMed
    7. Provance JB, Spertus JA, Jones PG, Hoffman MA, Bunte MC, Vogel TR, Mena-Hurtado C, Smolderen KG. Variability in 30-day major amputation rates following endovascular peripheral vascular intervention for critical limb ischemia. Vasc Med. 2022 08; 27(4):350-357. PMID: 35603755.
      View in: PubMed
    8. Jones BL, Hoffman M, Kane N. "Redlining" to "Hot Spots": The Impacts of a Continued Legacy of Structural and Institutional Racism and Bias on Asthma in Children. J Allergy Clin Immunol Pract. 2022 04; 10(4):992-993. PMID: 35397818.
      View in: PubMed
    9. Davis S, Ehwerhemuepha L, Feaster W, Hackman J, Morizono H, Kanakasabai S, Mosa ASM, Parker J, Iwamoto G, Patel N, Gasparino G, Kane N, Hoffman MA. Standardized Health data and Research Exchange (SHaRE): promoting a learning health system. JAMIA Open. 2022 Apr; 5(1):ooab120. PMID: 35047761.
      View in: PubMed
    10. Connelly M, Glynn EF, Hoffman MA, Bickel J. Rates and Predictors of Using Opioids in the Emergency Department to Treat Migraine in Adolescents and Young Adults. Pediatr Emerg Care. 2021 Dec 01; 37(12):e981-e987. PMID: 31246788.
      View in: PubMed
    11. Kyler KE, Lee BR, Glynn EF, Waddell JP, Hoffman MA, Goldman JL. Clinical Outcome and Antibiotic Dosing Differences by Weight in Children With Acute Osteomyelitis. Hosp Pediatr. 2021 10; 11(10):1112-1120. PMID: 34593567.
      View in: PubMed
    12. Sivasankar S, Cheng AL, Lubin IM, Lankachandra K, Hoffman MA. Use of large scale EHR data to evaluate A1c utilization among sickle cell disease patients. BMC Med Inform Decis Mak. 2021 09 18; 21(1):268. PMID: 34537047.
      View in: PubMed
    13. Kane NJ, Wang X, Gerkovich MM, Breitkreutz M, Rivera B, Kunchithapatham H, Hoffman MA. The Envirome Web Service: Patient context at the point of care. J Biomed Inform. 2021 07; 119:103817. PMID: 34020026.
      View in: PubMed
    14. Sivasankar S, Cheng AL, Hoffman M. Ranking Methodology to Evaluate the Severity of a Quality Gap Using a National EHR Database. AMIA Jt Summits Transl Sci Proc. 2021; 2021:565-574. PMID: 34457172.
      View in: PubMed
    15. Kyler KE, Bettenhausen JL, Hall M, Glynn EF, Hoffman MA, Shakhnovich V, Smolderen K, Davis AM. Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma. Hosp Pediatr. 2021 04; 11(4):380-388. PMID: 33664119.
      View in: PubMed
    16. Wood NM, Davis S, Lewing K, Noel-MacDonnell J, Glynn EF, Caragea D, Hoffman MA. Aligning EHR Data for Pediatric Leukemia With Standard Protocol Therapy. JCO Clin Cancer Inform. 2021 03; 5:239-251. PMID: 33656914.
      View in: PubMed
    17. Ehsan Z, Glynn EF, Hoffman MA, Ingram DG, Al-Shawwa B. Small sleepers, big data: leveraging big data to explore sleep-disordered breathing in infants and young children. Sleep. 2021 02 12; 44(2). PMID: 32926133.
      View in: PubMed
    18. Al-Shawwa B, Glynn E, Hoffman MA, Ehsan Z, Ingram DG. Outpatient health care utilization for sleep disorders in the Cerner Health Facts database. J Clin Sleep Med. 2021 02 01; 17(2):203-209. PMID: 32996459.
      View in: PubMed
    19. Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J. Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease. Transplantation. 2021 01 01; 105(1):18-22. PMID: 32639398.
      View in: PubMed
    20. McLaughlin MJ, Modrcin AC, Hickman TP, Hoffman M. Determining the impact of a clinic coordinator on patient access and clinic efficiency in a pediatric multidisciplinary spina bifida clinic using medical informatics. J Pediatr Rehabil Med. 2021; 14(4):661-666. PMID: 34806629.
      View in: PubMed
    21. McMahon AW, Cooper WO, Brown JS, Carleton B, Doshi-Velez F, Kohane I, Goldman JL, Hoffman MA, Kamaleswaran R, Sakiyama M, Sekine S, Sturkenboom MCJM, Turner MA, Califf RM. Big Data in the Assessment of Pediatric Medication Safety. Pediatrics. 2020 02; 145(2). PMID: 31937606.
      View in: PubMed
    22. Glynn EF, Hoffman MA. Heterogeneity introduced by EHR system implementation in a de-identified data resource from 100 non-affiliated organizations. JAMIA Open. 2019 Dec; 2(4):554-561. PMID: 32025653.
      View in: PubMed
    23. Talebizadeh Z, Shah A. Building a Bridge Between Genetics and Outcomes Research: Application in Autism (The AutGO Study). Patient. 2018 08; 11(4):451-462. PMID: 29508356.
      View in: PubMed
    24. Hoffman MA, Provance JB. Visualization of molecular structures using HoloLens-based augmented reality. AMIA Jt Summits Transl Sci Proc. 2017; 2017:68-74. PMID: 28815109.
      View in: PubMed
    25. Fowler SA, Saunders CJ, Hoffman MA. Variation among Consent Forms for Clinical Whole Exome Sequencing. J Genet Couns. 2018 02; 27(1):104-114. PMID: 28689263.
      View in: PubMed
    26. Shafiq A, Goyal A, Jones PG, Sahil S, Hoffman M, Qintar M, Buchanan DM, Kosiborod M, Arnold SV. Serum Magnesium Levels and In-Hospital Mortality in Acute Myocardial Infarction. J Am Coll Cardiol. 2017 06 06; 69(22):2771-2772. PMID: 28571644.
      View in: PubMed
    27. Cutting E, Banchero M, Beitelshees AL, Cimino JJ, Fiol GD, Gurses AP, Hoffman MA, Jeng LJ, Kawamoto K, Kelemen M, Pincus HA, Shuldiner AR, Williams MS, Pollin TI, Overby CL. User-centered design of multi-gene sequencing panel reports for clinicians. J Biomed Inform. 2016 10; 63:1-10. PMID: 27423699.
      View in: PubMed
    28. Tenenbaum JD, Avillach P, Benham-Hutchins M, Breitenstein MK, Crowgey EL, Hoffman MA, Jiang X, Madhavan S, Mattison JE, Nagarajan R, Ray B, Shin D, Visweswaran S, Zhao Z, Freimuth RR. An informatics research agenda to support precision medicine: seven key areas. J Am Med Inform Assoc. 2016 07; 23(4):791-5. PMID: 27107452.
      View in: PubMed
    29. Aziz A, Kawamoto K, Eilbeck K, Williams MS, Freimuth RR, Hoffman MA, Rasmussen LV, Overby CL, Shirts BH, Hoffman JM, Welch BM. The genomic CDS sandbox: An assessment among domain experts. J Biomed Inform. 2016 Apr; 60:84-94. PMID: 26778834.
      View in: PubMed
    30. DeShazo JP, Hoffman MA. A comparison of a multistate inpatient EHR database to the HCUP Nationwide Inpatient Sample. BMC Health Serv Res. 2015 Sep 15; 15:384. PMID: 26373538.
      View in: PubMed
    31. Laird-Maddox M, Mitchell SB, Hoffman M. Integrating research data capture into the electronic health record workflow: real-world experience to advance innovation. Perspect Health Inf Manag. 2014; 11:1e. PMID: 25593571.
      View in: PubMed
    32. Yu PP, Hoffman MA, Hayes DF. Biomarkers and oncology: the path forward to a learning health system. Arch Pathol Lab Med. 2015 Apr; 139(4):451-6. PMID: 25152310.
      View in: PubMed
    33. Masys DR, Jarvik GP, Abernethy NF, Anderson NR, Papanicolaou GJ, Paltoo DN, Hoffman MA, Kohane IS, Levy HP. Technical desiderata for the integration of genomic data into Electronic Health Records. J Biomed Inform. 2012 Jun; 45(3):419-22. PMID: 22223081.
      View in: PubMed
    34. Hoffman MA, Williams MS. Electronic medical records and personalized medicine. Hum Genet. 2011 Jul; 130(1):33-9. PMID: 21519832.
      View in: PubMed
    35. Deshmukh VG, Hoffman MA, Arnoldi C, Bray BE, Mitchell JA. Efficiency of CYP2C9 genetic test representation for automated pharmacogenetic decision support. Methods Inf Med. 2009; 48(3):282-90. PMID: 19387508.
      View in: PubMed
    36. Uy J, Brooks JT, Baker R, Hoffman M, Moorman A, Novak R. HIV genotypic resistance testing to optimize antiretroviral prescribing: is there room for improvement? Antivir Ther. 2007; 12(6):957-62. PMID: 17926650.
      View in: PubMed
    37. Hoffman MA, Menge C, Casey TA, Laegreid W, Bosworth BT, Dean-Nystrom EA. Bovine immune response to shiga-toxigenic Escherichia coli O157:H7. Clin Vaccine Immunol. 2006 Dec; 13(12):1322-7. PMID: 17050743.
      View in: PubMed
    38. Hoffman MA. The genome-enabled electronic medical record. J Biomed Inform. 2007 Feb; 40(1):44-6. PMID: 16616698.
      View in: PubMed
    39. Hoffman M, Arnoldi C, Chuang I. The clinical bioinformatics ontology: a curated semantic network utilizing RefSeq information. Pac Symp Biocomput. 2005; 139-50. PMID: 15759621.
      View in: PubMed
    40. Hoffman MA, Wilkinson TH, Bush A, Myers W, Griffin RG, Hoff GL, Archer R. Multijurisdictional approach to biosurveillance, Kansas City. Emerg Infect Dis. 2003 Oct; 9(10):1281-6. PMID: 14609464.
      View in: PubMed
    41. Laegreid W, Hoffman M, Keen J, Elder R, Kwang J. Development of a blocking enzyme-linked immunosorbent assay for detection of serum antibodies to O157 antigen of Escherichia coli. Clin Diagn Lab Immunol. 1998 Mar; 5(2):242-6. PMID: 9521150.
      View in: PubMed
    42. Hoffman M, Tremaine M, Mansfield J, Betley M. Biochemical and mutational analysis of the histidine residues of staphylococcal enterotoxin A. Infect Immun. 1996 Mar; 64(3):885-90. PMID: 8641796.
      View in: PubMed
    43. Hoffman MA, Duello D, Humphrey L. Computerized method and system for association a portion of a diagnostic image with an electronic medical record.
    44. Hoffman MA, Power K, Smith N, Ginger K. Computerized system and method for building a system of test components for a healthcare orderable procedure.
    45. Hoffman MA, Bush A, Gosch J. System and method for processing biologically significant events.
    46. Hoffman M, Power K, Kuhns G. A computerized system and method for automated correlation of genetic test results.
    47. Hoffman, M. A computerized system and method for documenting and presenting mutation observations.
    48. Hoffman, M. Kuhns, Ginger, Power, K. Automated detection of genetic test duplication.
    49. Hoffman, M. McCallie, D. Computerized method and system for inferring genetic finding for a patient.
    50. Hoffman, M. Power, K. Kuhns, G. Smith, N. Computerized system and method for building a system of test components for a healthcare orderable procedure.
    51. Hoffman, M. Documenting and presenting mutation observations.
    52. Nedblake, G. Hoffman, M. Power, K. Documentation of protocol orders.
    53. Nedblake, G. Hoffman, M. Power, K. Proactive correction alerts.
    54. Moussavi, M. Hoffman, M. Automated newborn screening reporting.
    55. Nedblake, G. Hoffman, M. Power, K. Shared protocol statements.
    56. Hoffman, M. McCallie, D. Computerized method and system for inferring genetic finding for a patient.
    57. Hoffman, M. Haven, S. Kuhns, G. Power, K . System and method for creating and displaying optional orders in healthcare environment.
    58. Hoffman, M. Power, K. Gorman, K. Bush, A. Siefert, M. Emons M. Associating multiple data sources into a web-accessible framework.
    59. Hoffman M., McCallie D. Computer system for providing information about the risk of an atypical clinical event based upon genetic information (Australian Patent).
    60. Hoffman M., McCallie D. Computer system for providing information about the risk of an atypical clinical event based upon genetic information (Canadian Patent).
    61. Hoffman, M; Haven, S; Nedblake, G; Power, K. System and method for creating and displaying optional order sets in healthcare environment.
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