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Search Results to Vivekanand Yadav

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research overview Diffuse midline gliomas (DMGs) are the most aggressive pediatric high-grade gliomas and are the leading cause of cancer-related deaths in children. At present, there are no effective therapies for DMGs tumors, and over 90% of patients die within 1.5 years of diagnosis. In his lab, Dr. Yadav is leading efforts to understand genetic and epigenetic dependencies and signaling pathways that arise as a consequence of the H3K27M mutation in DMG. His lab performs pre-clinical studies using a novel in utero electroporation (IUE)-derived genetically engineered mouse model to identify promising candidates that can be targeted as therapy for the treatment of DMG. 1-Identifying genomic and epigenetic drivers of pediatric brain tumors with specific genetic alterations (H3K27M or H3G34R/V) using next-generation sequencing and a novel in utero electroporation (IUE) genetically engineered mouse model. 2-Developing more effective treatments by dissecting the resistance mechanisms of pediatric brain tumors using genome-wide CRISPR-based genetic screens.

One or more keywords matched the following items that are connected to Yadav, Vivekanand

Item TypeName
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Mice, Transgenic
Concept Mice, SCID
Concept Mice, Inbred NOD
Concept Mice, Knockout
Concept Mice
Academic Article Everolimus improves the efficacy of dasatinib in PDGFRa-driven glioma.
Academic Article Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.
Academic Article Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
Academic Article ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization.
Academic Article Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Academic Article CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study.
Academic Article Survival and Proliferation of Neural Progenitor-Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism.
Academic Article Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Academic Article Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.
Academic Article Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.

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