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Leeder, J. Steven

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research overview

In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Alleles
Concept	Amino Acid Sequence
Concept	Base Sequence
Concept	Gene Amplification
Concept	Gene Expression Regulation
Concept	Gene Frequency
Concept	Molecular Sequence Data
Concept	Sequence Homology, Nucleic Acid
Concept	Gene Rearrangement
Concept	Molecular Structure
Concept	Gene Library
Concept	Gene Expression
Concept	Genome, Human
Concept	Gene Expression Regulation, Enzymologic
Concept	Open Reading Frames
Concept	Consensus Sequence
Concept	Genome
Concept	Gene Deletion
Concept	Sequence Homology, Amino Acid
Concept	Genes, Reporter
Concept	Gene Expression Regulation, Developmental
Concept	Gene Dosage
Concept	Gene Duplication
Concept	Polymorphism, Single Nucleotide
Concept	Gene Silencing
Concept	Gene Expression Profiling
Concept	RNA Splice Sites
Concept	Genetic Loci
Concept	Transcriptome
Concept	Exome
Concept	Gene Ontology
Academic Article	Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Academic Article	The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article	Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article	Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article	Variability of CYP3A7 expression in human fetal liver.
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article	Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article	Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article	Transcriptomic analysis of human lung development.
Academic Article	A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article	CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article	UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article	Selective Toll--like receptor expression in human fetal lung.
Academic Article	PharmGKB summary: methotrexate pathway.
Academic Article	Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article	Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article	CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article	Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article	Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article	Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article	Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article	Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article	Tissue-specific expression and alternative splicing of human microsomal epoxide hydrolase.
Academic Article	Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article	Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article	NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.
Academic Article	Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

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