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Leeder, J. Steven

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In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Ambulatory Care Facilities
Concept	Chromatography, High Pressure Liquid
Concept	Intensive Care Units, Neonatal
Concept	Predictive Value of Tests
Concept	Reference Values
Concept	Intensive Care Units, Pediatric
Concept	Health Care Costs
Concept	Delivery of Health Care, Integrated
Concept	High-Throughput Screening Assays
Concept	High-Throughput Nucleotide Sequencing
Academic Article	Pharmacogenetics and pharmacogenomics.
Academic Article	Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article	Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology.
Academic Article	Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article	Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article	A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article	Genome-wide prediction, display and refinement of binding sites with information theory-based models.
Academic Article	Variability of CYP3A7 expression in human fetal liver.
Academic Article	Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article	Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article	Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article	Personalized medicine: reality and reality checks.
Academic Article	Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article	Transcriptomic analysis of human lung development.
Academic Article	A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.
Academic Article	A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article	Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.
Academic Article	Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.
Academic Article	Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article	Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Academic Article	Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article	Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article	Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article	Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Academic Article	Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article	Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician.
Academic Article	Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.
Academic Article	Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article	Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article	Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Academic Article	Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Academic Article	Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article	Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article	Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.
Academic Article	Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article	Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article	High-pressure liquid chromatographic analysis of ceftazidime in serum and urine.
Academic Article	Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article	Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant	Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant	Clinical and Translational Mentored Career Development Award
Grant	Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article	Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.
Academic Article	Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant	Frontiers Clinical and Translational Science Institute at the University of Kansas
Grant	Ontogeny of drug transport
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Award or Honor Receipt	Clarivate Highly Cited Researcher – 2021, Pharmacology and Toxicology

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