 Glutamate-Cysteine Ligase
"Glutamate-Cysteine Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
| Descriptor ID |
D005721
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| MeSH Number(s) |
D08.811.464.259.850.400
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| Concept/Terms |
Glutamate-Cysteine Ligase- Glutamate-Cysteine Ligase
- Glutamate Cysteine Ligase
- Ligase, Glutamate-Cysteine
- gamma-Glutamyl-Cysteine Synthetase
- Synthetase, gamma-Glutamyl-Cysteine
- gamma Glutamyl Cysteine Synthetase
- Glutamylcysteine Synthetase
- Synthetase, Glutamylcysteine
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Below are MeSH descriptors whose meaning is more general than "Glutamate-Cysteine Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Cysteine Ligase".
This graph shows the total number of publications written about "Glutamate-Cysteine Ligase" by people in this website by year, and whether "Glutamate-Cysteine Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate-Cysteine Ligase" by people in Profiles.
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Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 05 07; 29(5):1166-1181.e6.
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Orlowski M, Karkowsky A. Glutathione metabolism and some possible functions of glutathione in the nervous system. Int Rev Neurobiol. 1976; 19:75-121.
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