Cyclic Nucleotide Phosphodiesterases, Type 2

"Cyclic Nucleotide Phosphodiesterases, Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

Descriptor ID	D054678
MeSH Number(s)	D08.811.277.352.640.150.200 D08.811.277.352.640.155.200 D12.644.360.008.200 D12.644.360.009.200 D12.776.476.008.200 D12.776.476.009.200
Concept/Terms	Cyclic Nucleotide Phosphodiesterases, Type 2 Cyclic Nucleotide Phosphodiesterases, Type 2 PDE2 Phosphodiesterases PDE2 Phosphodiesterase Cyclic GMP-Stimulated Phosphodiesterase Cyclic GMP Stimulated Phosphodiesterase Phosphodiesterase, Cyclic GMP-Stimulated Cyclic Nucleotide Phosphodiesterase PDE2 Family Cyclic Nucleotide Phosphodiesterases, Type 2A Cyclic Nucleotide Phosphodiesterases, Type 2A Phosphodiesterase 2A cGMP-Dependent 3',5'-Cyclic Phosphodiesterase 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent cGMP Dependent 3',5' Cyclic Phosphodiesterase

Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Diester Hydrolases [D08.811.277.352.640]
3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.155.200]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.644.360.008.200]
3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.644.360.009.200]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.776.476.008.200]
3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
Cyclic Nucleotide Phosphodiesterases, Type 2 [D12.776.476.009.200]

Below are MeSH descriptors whose meaning is related to "Cyclic Nucleotide Phosphodiesterases, Type 2".

Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 2".

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