 eIF-2 Kinase
"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
| Descriptor ID |
D019892
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| MeSH Number(s) |
D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
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| Concept/Terms |
eIF-2 Kinase- eIF-2 Kinase
- Kinase, eIF-2
- eIF 2 Kinase
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- Inhibitor, dsRNA-Activated
- dsRNA Activated Inhibitor
- DSRNA-Dep Protein Kinase
- DSRNA Dep Protein Kinase
- Kinase, DSRNA-Dep Protein
- Protein Kinase, DSRNA-Dep
- eIF-2alpha Kinase
- Kinase, eIF-2alpha
- eIF 2alpha Kinase
- eRF, eIF-2 Recycling Factor
- eRF, eIF 2 Recycling Factor
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Controlled Repressor, Heme
- Repressor, Heme Controlled
- Heme-Controlled Inhibitor
- Heme Controlled Inhibitor
- Inhibitor, Heme-Controlled
- Heme-Controlled Translational Repressor
- Heme Controlled Translational Repressor
- Repressor, Heme-Controlled Translational
- Translational Repressor, Heme-Controlled
- Heme-Regulated eIF-2alpha Kinase
- Heme Regulated eIF 2alpha Kinase
- Kinase, Heme-Regulated eIF-2alpha
- eIF-2alpha Kinase, Heme-Regulated
- Hemin Controlled Repressor
- Controlled Repressor, Hemin
- Repressor, Hemin Controlled
- Hemin-Controlled Translational Repressor
- Hemin Controlled Translational Repressor
- Repressor, Hemin-Controlled Translational
- Translational Repressor, Hemin-Controlled
- p65 Kinase
- Kinase, p65
- p68 Kinase
- Kinase, p68
- P68 Protein Kinase
- Kinase, P68 Protein
- Protein Kinase, P68
- Protein Kinase PKR
- Kinase PKR, Protein
- PKR, Protein Kinase
- Protein Kinase, RNA Activated
- RNA-Dependent Protein Kinase
- Kinase, RNA-Dependent Protein
- Protein Kinase, RNA-Dependent
- RNA Dependent Protein Kinase
- Self-Phosphorylating Protein Kinase
- Kinase, Self-Phosphorylating Protein
- Protein Kinase, Self-Phosphorylating
- Self Phosphorylating Protein Kinase
- TIK Kinase
- Kinase, TIK
- DAI Protein Kinase
- Kinase, DAI Protein
- Protein Kinase, DAI
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Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".
This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.
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Mao D, Reuter CM, Ruzhnikov MRZ, Beck AE, Farrow EG, Emrick LT, Rosenfeld JA, Mackenzie KM, Robak L, Wheeler MT, Burrage LC, Jain M, Liu P, Calame D, K?ry S, Sillesen M, Schmitz-Abe K, Tonduti D, Spaccini L, Iascone M, Genetti CA, Koenig MK, Graf M, Tran A, Alejandro M, Lee BH, Thiffault I, Agrawal PB, Bernstein JA, Bellen HJ, Chao HT. De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation. Am J Hum Genet. 2020 04 02; 106(4):570-583.
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Yang WQ, Senger D, Muzik H, Shi ZQ, Johnson D, Brasher PM, Rewcastle NB, Hamilton M, Rutka J, Wolff J, Wetmore C, Curran T, Lee PW, Forsyth PA. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res. 2003 Jun 15; 63(12):3162-72.
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