The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.

Descriptor ID	D018773
MeSH Number(s)	G05.360.340.024.340.375.500.791.295.300
Concept/Terms	Genes, erbB-1 Genes, erbB-1 Genes, erbB1 Gene, erbB1 erbB1 Gene erbB1 Genes erbB-1 Genes erbB 1 Genes erbB-1 Gene v-erbB Genes v-erbB Genes v erbB Genes v-erbB Gene v-erbB Oncogenes v erbB Oncogenes v-erbB Oncogene c-erbB-1 Genes c-erbB-1 Genes c erbB 1 Genes c-erbB-1 Gene EGFR Genes Epidermal Growth Factor Receptor Genes c-erbB-1 Proto-Oncogenes c erbB 1 Proto Oncogenes c-erbB-1 Proto-Oncogene Genes, EGFR EGFR Gene

Below are MeSH descriptors whose meaning is more general than "Genes, erbB-1".

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Below are MeSH descriptors whose meaning is more specific than "Genes, erbB-1".