 Renin-Angiotensin System
"Renin-Angiotensin System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
| Descriptor ID |
D012084
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| MeSH Number(s) |
G03.495.805 G09.330.190.400.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Renin-Angiotensin System".
Below are MeSH descriptors whose meaning is more specific than "Renin-Angiotensin System".
This graph shows the total number of publications written about "Renin-Angiotensin System" by people in this website by year, and whether "Renin-Angiotensin System" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Renin-Angiotensin System" by people in Profiles.
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Srivastava T, Hariharan S, Alon US, McCarthy ET, Sharma R, El-Meanawy A, Savin VJ, Sharma M. Hyperfiltration-mediated Injury in the Remaining Kidney of a Transplant Donor. Transplantation. 2018 10; 102(10):1624-1635.
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Meier R, Bi C, Gaedigk R, Heruth DP, Ye SQ, Leeder JS, Fridley BL. Ontogeny-related pharmacogene changes in the pediatric liver transcriptome. Pharmacogenet Genomics. 2018 03; 28(3):86-94.
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Abraham AG, Betoko A, Fadrowski JJ, Pierce C, Furth SL, Warady BA, Mu?oz A. Renin-angiotensin II-aldosterone system blockers and time to renal replacement therapy in children with CKD. Pediatr Nephrol. 2017 04; 32(4):643-649.
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Friedman K, Wallis T, Maloney KW, Hendrickson RJ, Mengshol S, Cadnapaphornchai MA. An unusual cause of pediatric hypertension. J Pediatr. 2007 Aug; 151(2):206-12.
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