Dosage Compensation, Genetic
"Dosage Compensation, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Descriptor ID |
D004303
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MeSH Number(s) |
G05.355.315.203.249
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Concept/Terms |
Dosage Compensation, Genetic- Dosage Compensation, Genetic
- Compensation, Genetic Dosage
- Genetic Dosage Compensation
- Genetic Dosage Compensations
- Gene Dosage Compensation
- Compensation, Gene Dosage
- Dosage Compensation, Gene
- Gene Dosage Compensations
- Dosage Compensation (Genetics)
- Compensation, Dosage (Genetics)
X-Chromosome Hypertranscription- X-Chromosome Hypertranscription
- X Chromosome Hypertranscription
- Hypertranscription, X-Chromosome
- Hypertranscription, X Chromosome
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Below are MeSH descriptors whose meaning is more general than "Dosage Compensation, Genetic".
Below are MeSH descriptors whose meaning is more specific than "Dosage Compensation, Genetic".
This graph shows the total number of publications written about "Dosage Compensation, Genetic" by people in this website by year, and whether "Dosage Compensation, Genetic" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dosage Compensation, Genetic" by people in Profiles.
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Bittel DC, Theodoro MF, Kibiryeva N, Fischer W, Talebizadeh Z, Butler MG. Comparison of X-chromosome inactivation patterns in multiple tissues from human females. J Med Genet. 2008 May; 45(5):309-13.
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Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Lepage P, Lavergne K, Villeneuve A, Gaudin T, Br?ndstr?m H, Beck A, Verner A, Kingsley J, Harmsen E, Labuda D, Morgan K, Vohl MC, Naumova AK, Sinnett D, Hudson TJ. A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics. 2004 Jan 15; 16(2):184-93.
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