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Laura Ramsey, PhD

TitleDoctoral Research Faculty
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City Missouri 64108
ORCID ORCID Icon0000-0001-6417-3961 Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    St Jude Children's Research Hospital, Memphis, TN Postdoctoral Fellowship2015Pharmacogenetics
    University of Minnesota , Minneapolis, MNPhD2009Molecular, Cellular, Developmental Biology & Genetics
    University of Northern Iowa, Cedar Falls, IAB.S2004Chemistry with Biochemistry emphasis, summa cum laude
    University of Northern Iowa, Cedar Falls, IAB.A2004Biotechnology
    Collapse awards and honors
    2019Darrell Abernethy Early Stage Investigator Award, American Society for Clinical Pharmacology & Therapeutics

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Ramsey joined Children’s Mercy in 2023 as the Section Chief of Individualized Therapeutics in the Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation. She is leading the implementation of a pharmacogenomics program that is fully integrated with the electronic health record, and she is developing model-informed decision support for several medications. Before joining Children’s Mercy, Dr. Ramsey was an Associate Professor at Cincinnati Children’s Hospital Medical Center, co-director of the Genetic Pharmacology Service, and co-director of the Clinical Pharmacology Fellowship program. She completed her postdoctoral fellowship in Pharmacogenetics at St. Jude Children’s Research Hospital and received her PhD in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota – Twin Cities.
    Dr. Ramsey is interested in all aspects of pharmacogenetics, from basic research to implementation in patient care. She has led projects to study pharmacogenetic variants that influence response, toxicity, and dosing of antidepressants, immunosuppressants, and chemotherapy in children. She has authored over 100 peer-reviewed manuscripts, hundreds of abstract presentations, and is extramurally funded, including a National Institutes of Health R01 award.
    Collapse research activities and funding
    T32HD069038     (GOLDMAN, JENNIFER LYNN;WAGNER, JONATHAN)May 1, 2011 - Apr 30, 2026
    NIH
    Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
    Role: Principal Investigator

    R01HD089928     (THOMPSON, SUSAN D)Sep 1, 2017 - May 31, 2022
    NIH
    Identifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIA
    Role: Co-Investigator

    R01HD099775     (RAMSEY, LAURA B ;STRAWN, JEFFREY ROBERT)Sep 21, 2020 - Jun 30, 2025
    NIH
    Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety Disorders Using Pharmacogenetically-guided Dosing
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Poweleit EA, Taylor ZL, Mizuno T, Vaughn SE, Desta Z, Strawn JR, Ramsey LB. Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients. Clin Pharmacokinet. 2023 11; 62(11):1621-1637. PMID: 37755681.
      View in: PubMed
    2. Taylor ZL, Miller TP, Poweleit EA, DeGroote NP, Pommert L, Awoniyi O, Board SG, Ugboh N, Joshi V, Ambrosino N, Chavana A, Bernhardt MB, Schafer ES, O'Brien MM, Castellino SM, Ramsey LB. Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org. Clin Transl Sci. 2023 Jul 28. PMID: 37503924.
      View in: PubMed
    3. Ramsey LB, Prows CA, Tang Girdwood S, Van Driest S. Current Practices in Pharmacogenomics. Pediatr Clin North Am. 2023 10; 70(5):995-1011. PMID: 37704356.
      View in: PubMed
    4. Le J, Ramsey LB. Enhancing pharmacokinetic and pharmacodynamic knowledge in pediatrics. Pharmacotherapy. 2023 07; 43(7):578. PMID: 37435987.
      View in: PubMed
    5. Alghamdi A, Seay S, Hooper DK, Varnell CD, Darland L, Mizuno T, Lazear D, Ramsey LB. Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients. Clin Transl Sci. 2023 10; 16(10):1768-1778. PMID: 37340713.
      View in: PubMed
    6. Ramsey LB, Prows CA, Chidambaran V, Sadhasivam S, Quinn CT, Teusink-Cross A, Tang Girdwood S, Dawson DB, Vinks AA, Glauser TA. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center. Am J Health Syst Pharm. 2023 Jun 22; 80(13):852-859. PMID: 36715063.
      View in: PubMed
    7. Bousman CA, Stevenson JM, Ramsey LB, Sangkuhl K, Hicks JK, Strawn JR, Singh AB, Rua?o G, Mueller DJ, Tsermpini EE, Brown JT, Bell GC, Leeder JS, Gaedigk A, Scott SA, Klein TE, Caudle KE, Bishop JR. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clin Pharmacol Ther. 2023 07; 114(1):51-68. PMID: 37032427.
      View in: PubMed
    8. Kehinde O, Ramsey LB, Gaedigk A, Oni-Orisan A. Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens. Clin Pharmacol Ther. 2023 07; 114(1):69-76. PMID: 36924260.
      View in: PubMed
    9. Strawn JR, Mills JA, Poweleit EA, Ramsey LB, Croarkin PE. Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents. Pharmacotherapy. 2023 07; 43(7):675-690. PMID: 36651686.
      View in: PubMed
    10. Haga SB, Chung WK, Cubano LA, Curry TB, Empey PE, Ginsburg GS, Mangold K, Miyake CY, Prakash SK, Ramsey LB, Rowley R, Rohrer Vitek CR, Skaar TC, Wynn J, Manolio TA. Development of Competency-based Online Genomic Medicine Training (COGENT). Per Med. 2023 01; 20(1):55-64. PMID: 36416152.
      View in: PubMed
    11. Ibarra M, Combs R, Taylor ZL, Ramsey LB, Mikkelsen T, Buddington RK, Heldrup J, Barreto JN, Guscott M, Lowe J, Hurmiz C, Marada S, Howard SC, Schaiquevich P. Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing. Br J Clin Pharmacol. 2023 02; 89(2):660-671. PMID: 35998099.
      View in: PubMed
    12. Sperber NR, Cragun D, Roberts MC, Bendz LM, Ince P, Gonzales S, Haga SB, Wu RR, Petry NJ, Ramsey L, Uber R. A Mixed-Methods Protocol to Identify Best Practices for Implementing Pharmacogenetic Testing in Clinical Settings. J Pers Med. 2022 Aug 13; 12(8). PMID: 36013262.
      View in: PubMed
    13. Ramsey LB, Gong L, Lee SB, Wagner JB, Zhou X, Sangkuhl K, Adams SM, Straka RJ, Empey PE, Boone EC, Klein TE, Niemi M, Gaedigk A. PharmVar GeneFocus: SLCO1B1. Clin Pharmacol Ther. 2023 04; 113(4):782-793. PMID: 35797228.
      View in: PubMed
    14. Bopp EA, Poweleit EA, Cox MO, Farrow JE, Strawn JR, Patino Duran LR, Prows CA, DelBello MP, Ramsey LB. A retrospective examination of adjunctive L-methylfolate in children and adolescents with unipolar depression. J Affect Disord. 2022 09 01; 312:315-321. PMID: 35753502.
      View in: PubMed
    15. Honeycutt DC, DelBello MP, Strawn JR, Ramsey LB, Patino LR, Hinman K, Welge J, Miklowitz DJ, Jo B, Blom TJ, Bruns KM, Hamill Skoch SK, Starace N, Tallman MJ, Singh MK. A Double-Blind Randomized Trial to Investigate Mechanisms of Antidepressant-Related Dysfunctional Arousal in Depressed or Anxious Youth at Familial Risk for Bipolar Disorder. J Pers Med. 2022 Jun 20; 12(6). PMID: 35743790.
      View in: PubMed
    16. Salloum RG, Bishop JR, Elchynski AL, Smith DM, Rowe E, Blake KV, Limdi NA, Aquilante CL, Bates J, Beitelshees AL, Cipriani A, Duong BQ, Empey PE, Formea CM, Hicks JK, Mroz P, Oslin D, Pasternak AL, Petry N, Ramsey LB, Schlichte A, Swain SM, Ward KM, Wiisanen K, Skaar TC, Van Driest SL, Cavallari LH, Tuteja S. Best-worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy. Implement Sci Commun. 2022 May 14; 3(1):52. PMID: 35568931.
      View in: PubMed
    17. Strawn JR, Vaughn S, Ramsey LB. Pediatric Psychopharmacology for Depressive and Anxiety Disorders. Focus (Am Psychiatr Publ). 2022 Apr; 20(2):184-190. PMID: 37153132.
      View in: PubMed
    18. Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. Clin Pharmacol Ther. 2022 05; 111(5):1007-1021. PMID: 35152405.
      View in: PubMed
    19. Poweleit EA, Cinibulk MA, Novotny SA, Wagner-Schuman M, Ramsey LB, Strawn JR. Selective Serotonin Reuptake Inhibitor Pharmacokinetics During Pregnancy: Clinical and Research Implications. Front Pharmacol. 2022; 13:833217. PMID: 35281909.
      View in: PubMed
    20. Strawn JR, Poweleit EA, Mills JA, Schroeder HK, Neptune ZA, Specht AM, Farrow JE, Zhang X, Martin LJ, Ramsey LB. Pharmacogenetically Guided Escitalopram Treatment for Pediatric Anxiety Disorders: Protocol for a Double-Blind Randomized Trial. J Pers Med. 2021 Nov 12; 11(11). PMID: 34834540.
      View in: PubMed
    21. Namerow LB, Ramsey LB, Malik S, Cortese S, Strawn JR. Editorial: Beyond Red Light, Green Light: Examining the Role of Pharmacogenomics in Evidence-Based Care in Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 2022 01; 61(1):29-31. PMID: 34767918.
      View in: PubMed
    22. Edwards A, Teusink-Cross A, Martin LJ, Prows CA, Mehta PA, Ramsey LB. Influence of CYP2D6 metabolizer status on ondansetron efficacy in pediatric patients undergoing hematopoietic stem cell transplantation: A case series. Clin Transl Sci. 2022 03; 15(3):610-618. PMID: 34670017.
      View in: PubMed
    23. Strawn JR, Poweleit EA, Uppugunduri CRS, Ramsey LB. Pediatric Therapeutic Drug Monitoring for Selective Serotonin Reuptake Inhibitors. Front Pharmacol. 2021; 12:749692. PMID: 34658889.
      View in: PubMed
    24. Tuteja S, Salloum RG, Elchynski AL, Smith DM, Rowe E, Blake KV, Limdi NA, Aquilante CL, Bates J, Beitelshees AL, Cipriani A, Duong BQ, Empey PE, Formea CM, Hicks JK, Mroz P, Oslin D, Pasternak AL, Petry N, Ramsey LB, Schlichte A, Swain SM, Ward KM, Wiisanen K, Skaar TC, Van Driest SL, Cavallari LH, Bishop JR. Multisite evaluation of institutional processes and implementation determinants for pharmacogenetic testing to guide antidepressant therapy. Clin Transl Sci. 2022 02; 15(2):371-383. PMID: 34562070.
      View in: PubMed
    25. Mehta RS, Taylor ZL, Martin LJ, Rosen MJ, Ramsey LB. SLCO1B1 *15 allele is associated with methotrexate-induced nausea in pediatric patients with inflammatory bowel disease. Clin Transl Sci. 2022 01; 15(1):63-69. PMID: 34423897.
      View in: PubMed
    26. Ramsey LB, Gaedigk A. CYP2D6*9 and *41: Does the Activity Value Assigned to these Alleles Need to be Reduced to more Accurately Predict Phenotype? Clin Pharmacol Ther. 2022 06; 111(6):1208-1211. PMID: 34352934.
      View in: PubMed
    27. Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network. Clin Pharmacol Ther. 2021 09; 110(3):559-562. PMID: 34318925.
      View in: PubMed
    28. Duarte JD, Dalton R, Elchynski AL, Smith DM, Cicali EJ, Lee JC, Duong BQ, Petry NJ, Aquilante CL, Beitelshees AL, Empey PE, Johnson JA, Obeng AO, Pasternak AL, Pratt VM, Ramsey LB, Tuteja S, Van Driest SL, Wiisanen K, Hicks JK, Cavallari LH. Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing. Genet Med. 2021 12; 23(12):2335-2341. PMID: 34282303.
      View in: PubMed
    29. Taylor ZL, Thompson LE, Bear H, Mizuno T, Vinks AA, Ramsey LB. Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clin Transl Sci. 2021 11; 14(6):2267-2277. PMID: 34121338.
      View in: PubMed
    30. Vaughn SE, Strawn JR, Poweleit EA, Sarangdhar M, Ramsey LB. The Impact of Marijuana on Antidepressant Treatment in Adolescents: Clinical and Pharmacologic Considerations. J Pers Med. 2021 Jun 29; 11(7). PMID: 34209709.
      View in: PubMed
    31. Hertz DL, Ramsey LB, Gopalakrishnan M, Leeder JS, Van Driest SL. Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics. Clin Pharmacol Ther. 2021 09; 110(3):589-594. PMID: 34043820.
      View in: PubMed
    32. Hertz DL, Arwood MJ, Stocco G, Singh S, Karnes JH, Ramsey LB. Planning and Conducting a Pharmacogenetics Association Study. Clin Pharmacol Ther. 2021 09; 110(3):688-701. PMID: 33880756.
      View in: PubMed
    33. Taylor ZL, Vang J, Lopez-Lopez E, Oosterom N, Mikkelsen T, Ramsey LB. Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies. Cancers (Basel). 2021 Jun 07; 13(11). PMID: 34200242.
      View in: PubMed
    34. Rossow KM, Vaughn SE, Strawn JR, Van Driest SL, Ramsey LB. The need for a refined understanding of CYP2D6 in second-generation antipsychotic outcomes in children and adolescents. Pharmacogenomics. 2021 06; 22(8):447-450. PMID: 34032507.
      View in: PubMed
    35. Tang Girdwood SC, Rossow KM, Van Driest SL, Ramsey LB. Perspectives from the Society for Pediatric Research: pharmacogenetics for pediatricians. Pediatr Res. 2022 02; 91(3):529-538. PMID: 33824446.
      View in: PubMed
    36. Hicks JK, El Rouby N, Ong HH, Schildcrout JS, Ramsey LB, Shi Y, Anne Tang L, Aquilante CL, Beitelshees AL, Blake KV, Cimino JJ, Davis BH, Empey PE, Kao DP, Lemkin DL, Limdi NA, P Lipori G, Rosenman MB, Skaar TC, Teal E, Tuteja S, Wiley LK, Williams H, Winterstein AG, Van Driest SL, Cavallari LH, Peterson JF. Opportunity for Genotype-Guided Prescribing Among Adult Patients in 11 US Health Systems. Clin Pharmacol Ther. 2021 07; 110(1):179-188. PMID: 33428770.
      View in: PubMed
    37. Hamill Skoch S, Mills JA, Ramsey L, Strawn JR. Letter to the Editor: Sleep Disturbances in Selective Serotonin Reuptake Inhibitor-Treated Youth with Anxiety Disorders and Obsessive Compulsive Disorder-A Bayesian Hierarchical Modeling Meta-Analysis. J Child Adolesc Psychopharmacol. 2021 06; 31(5):387-388. PMID: 33571033.
      View in: PubMed
    38. Lu L, Mills JA, Li H, Schroeder HK, Mossman SA, Varney ST, Cecil KM, Huang X, Gong Q, Ramsey LB, DelBello MP, Sweeney JA, Strawn JR. Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety: A Double-Blind, Placebo-Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2021 10; 60(10):1309-1318. PMID: 33548492.
      View in: PubMed
    39. Brown JT, Ramsey LB, Van Driest SL, Aka I, Colace SI. Characterizing Pharmacogenetic Testing Among Children's Hospitals. Clin Transl Sci. 2021 03; 14(2):692-701. PMID: 33325650.
      View in: PubMed
    40. Ramsey LB, Ong HH, Schildcrout JS, Shi Y, Tang LA, Hicks JK, El Rouby N, Cavallari LH, Tuteja S, Aquilante CL, Beitelshees AL, Lemkin DL, Blake KV, Williams H, Cimino JJ, Davis BH, Limdi NA, Empey PE, Horvat CM, Kao DP, Lipori GP, Rosenman MB, Skaar TC, Teal E, Winterstein AG, Owusu Obeng A, Salyakina D, Gupta A, Gruber J, McCafferty-Fernandez J, Bishop JR, Rivers Z, Benner A, Tamraz B, Long-Boyle J, Peterson JF, Van Driest SL. Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients. JAMA Netw Open. 2020 12 01; 3(12):e2029411. PMID: 33315113.
      View in: PubMed
    41. Ramsey LB, Namerow LB, Bishop JR, Hicks JK, Bousman C, Croarkin PE, Mathews CA, Van Driest SL, Strawn JR. Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology. J Am Acad Child Adolesc Psychiatry. 2021 06; 60(6):660-664. PMID: 32860906.
      View in: PubMed
    42. Strawn JR, Mills JA, Schroeder H, Mossman SA, Varney ST, Ramsey LB, Poweleit EA, Desta Z, Cecil K, DelBello MP. Escitalopram in Adolescents With Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study. J Clin Psychiatry. 2020 08 25; 81(5). PMID: 32857933.
      View in: PubMed
    43. Jallaq SA, Verba M, Strawn JR, Martin LJ, DelBello MP, Ramsey LB. CYP2D6 Phenotype Influences Aripiprazole Tolerability in Pediatric Patients with Mood Disorders. J Child Adolesc Psychopharmacol. 2021 02; 31(1):56-62. PMID: 32845723.
      View in: PubMed
    44. Taylor ZL, Mizuno T, Punt NC, Baskaran B, Navarro Sainz A, Shuman W, Felicelli N, Vinks AA, Heldrup J, Ramsey LB. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clin Pharmacol Ther. 2020 09; 108(3):635-643. PMID: 32558929.
      View in: PubMed
    45. Mizuno T, Dong M, Taylor ZL, Ramsey LB, Vinks AA. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. Br J Clin Pharmacol. 2022 02; 88(4):1418-1426. PMID: 32529759.
      View in: PubMed
    46. Sonmez AI, Almorsy A, Ramsey LB, Strawn JR, Croarkin PE. Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations. Depress Anxiety. 2020 08; 37(8):747-759. PMID: 32419335.
      View in: PubMed
    47. Troy TF, Poweleit EA, Strawn JR, Martin LJ, Ramsey LB. The Influence of Pharmacodynamic Genes on Fluoxetine Response in Pediatric Anxiety and Depressive Disorders. J Child Adolesc Psychopharmacol. 2020 05; 30(4):276-277. PMID: 32073889.
      View in: PubMed
    48. Huddart R, Hicks JK, Ramsey LB, Strawn JR, Smith DM, Bobonis Babilonia M, Altman RB, Klein TE. PharmGKB summary: sertraline pathway, pharmacokinetics. Pharmacogenet Genomics. 2020 02; 30(2):26-33. PMID: 31851125.
      View in: PubMed
    49. Poweleit EA, Colestock M, Kantemneni EC, Strawn JR, Patino LR, DelBello MP, Ramsey LB. Cariprazine in Youth with Bipolar and Psychotic Disorders: A Retrospective Chart Review. J Child Adolesc Psychopharmacol. 2020 05; 30(4):267-272. PMID: 31825249.
      View in: PubMed
    50. Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A. A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy. Clin Pharmacol Ther. 2020 01; 107(1):50-52. PMID: 31664715.
      View in: PubMed
    51. Finch ER, Smith CA, Yang W, Liu Y, Kornegay NM, Panetta JC, Crews KR, Molinelli AR, Cheng C, Pei D, Ramsey LB, Karol SE, Inaba H, Sandlund JT, Metzger M, Evans WE, Jeha S, Pui CH, Relling MV. Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2020 01; 67(1):e28040. PMID: 31612640.
      View in: PubMed
    52. Luft MJ, Aldrich SL, Poweleit E, Prows CA, Martin LJ, DelBello MP, Keeshin BR, Ramsey LB, Strawn JR. Thyroid Function Screening in Children and Adolescents With Mood and Anxiety Disorders. J Clin Psychiatry. 2019 08 06; 80(5). PMID: 31390496.
      View in: PubMed
    53. Ramsey LB, Bishop JR, Strawn JR. Pharmacogenetics of treating pediatric anxiety and depression. Pharmacogenomics. 2019 08; 20(12):867-870. PMID: 31453769.
      View in: PubMed
    54. Ramsey LB, Brown JT, Vear SI, Bishop JR, Van Driest SL. Gene-Based Dose Optimization in Children. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:311-331. PMID: 31283429.
      View in: PubMed
    55. Hachad H, Ramsey LB, Scott SA. Interpreting and Implementing Clinical Pharmacogenetic Tests: Perspectives From Service Providers. Clin Pharmacol Ther. 2019 08; 106(2):298-301. PMID: 31162629.
      View in: PubMed
    56. Poweleit EA, Aldrich SL, Martin LJ, Hahn D, Strawn JR, Ramsey LB. Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders. J Child Adolesc Psychopharmacol. 2019 06; 29(5):348-361. PMID: 31066578.
      View in: PubMed
    57. Karol SE, Janke LJ, Panetta JC, Ramsey LB, Cai X, Payton MA, Jenkins DA, Evans WE, Relling MV. Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models. PLoS One. 2019; 14(5):e0216328. PMID: 31059548.
      View in: PubMed
    58. Cavallari LH, Van Driest SL, Prows CA, Bishop JR, Limdi NA, Pratt VM, Ramsey LB, Smith DM, Tuteja S, Duong BQ, Hicks JK, Lee JC, Obeng AO, Beitelshees AL, Bell GC, Blake K, Crona DJ, Dressler L, Gregg RA, Hines LJ, Scott SA, Shelton RC, Weitzel KW, Johnson JA, Peterson JF, Empey PE, Skaar TC. Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing. Genet Med. 2019 10; 21(10):2255-2263. PMID: 30894703.
      View in: PubMed
    59. Ramsey LB, Moncrieffe H, Smith CN, Sudman M, Marion MC, Langefeld CD, Becker ML, Thompson SD. Association of SLCO1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients. ACR Open Rheumatol. 2019 Mar; 1(1):58-62. PMID: 31777781.
      View in: PubMed
    60. Strawn JR, Poweleit EA, Ramsey LB. CYP2C19-Guided Escitalopram and Sertraline Dosing in Pediatric Patients: A Pharmacokinetic Modeling Study. J Child Adolesc Psychopharmacol. 2019 06; 29(5):340-347. PMID: 30817183.
      View in: PubMed
    61. Aldrich SL, Poweleit EA, Prows CA, Martin LJ, Strawn JR, Ramsey LB. Influence of CYP2C19 Metabolizer Status on Escitalopram/Citalopram Tolerability and Response in Youth With Anxiety and Depressive Disorders. Front Pharmacol. 2019; 10:99. PMID: 30837874.
      View in: PubMed
    62. Ramsey LB, Mizuno T, Vinks AA, O'Brien MM. Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib. Pediatr Blood Cancer. 2019 05; 66(5):e27618. PMID: 30677213.
      View in: PubMed
    63. Ramsey LB, Aldrich SL, Poweleit E, Prows CA, Martin LJ, Strawn JR. Racial Differences in Escitalopram/Citalopram-Related Weight Gain in Children and Adolescents: A Natural Language Processing-Based Electronic Medical Record Study. J Child Adolesc Psychopharmacol. 2019 03; 29(2):162-163. PMID: 30427735.
      View in: PubMed
    64. Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA. Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma. Mol Cancer Res. 2019 02; 17(2):567-582. PMID: 30355676.
      View in: PubMed
    65. Ramsey LB, Prows CA, Zhang K, Salda?a SN, Sorter MT, Pestian JP, Wenstrup RJ, Vinks AA, Glauser TA. Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine. Clin Pharmacol Ther. 2019 01; 105(1):49-52. PMID: 30058217.
      View in: PubMed
    66. Wehry AM, Ramsey L, Dulemba SE, Mossman SA, Strawn JR. Pharmacogenomic Testing in Child and Adolescent Psychiatry: An Evidence-Based Review. Curr Probl Pediatr Adolesc Health Care. 2018 02; 48(2):40-49. PMID: 29325731.
      View in: PubMed
    67. Ramsey LB, Balis FM, O'Brien MM, Schmiegelow K, Pauley JL, Bleyer A, Widemann BC, Askenazi D, Bergeron S, Shirali A, Schwartz S, Vinks AA, Heldrup J. Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance. Oncologist. 2018 01; 23(1):52-61. PMID: 29079637.
      View in: PubMed
    68. Maxwell WD, Ramsey LB, Johnson SG, Moore KG, Shtutman M, Schoonover JH, Kawaguchi-Suzuki M. Impact of Pharmacogenetics on Efficacy and Safety of Statin Therapy for Dyslipidemia. Pharmacotherapy. 2017 Sep; 37(9):1172-1190. PMID: 28672099.
      View in: PubMed
    69. Ramsey LB, Pounds S, Cheng C, Cao X, Yang W, Smith C, Karol SE, Liu C, Panetta JC, Inaba H, Rubnitz JE, Metzger ML, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Evans WE, Relling MV. Genetics of pleiotropic effects of dexamethasone. Pharmacogenet Genomics. 2017 08; 27(8):294-302. PMID: 28628558.
      View in: PubMed
    70. Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV. Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy. Clin Pharmacol Ther. 2017 07; 102(1):131-140. PMID: 28090653.
      View in: PubMed
    71. Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, M?schen M, Kornblau SM, Farrar MA. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 06; 18(6):694-704. PMID: 28369050.
      View in: PubMed
    72. Ramsey LB, Mizuno T, Vinks AA, Margolis PA. Learning Health Systems as Facilitators of Precision Medicine. Clin Pharmacol Ther. 2017 03; 101(3):359-367. PMID: 27984650.
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    73. Karol SE, Larsen E, Cheng C, Cao X, Yang W, Ramsey LB, Fernandez CA, McCorkle JR, Paugh SW, Autry RJ, Lopez-Lopez E, Diouf B, Jeha S, Pui CH, Raetz EA, Winick NJ, Carroll WL, Hunger SP, Loh ML, Devidas M, Evans WE, Yang JJ, Relling MV. Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia. Leukemia. 2017 06; 31(6):1325-1332. PMID: 28096535.
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    74. Liu C, Janke LJ, Kawedia JD, Ramsey LB, Cai X, Mattano LA, Boyd KL, Funk AJ, Relling MV. Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model. PLoS One. 2016; 11(3):e0151433. PMID: 26967741.
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    75. Karol SE, Mattano LA, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV. Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood. 2016 Feb 04; 127(5):558-64. PMID: 26590194.
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    76. Ramsey LB, Janke LJ, Payton MA, Cai X, Paugh SW, Karol SE, Kamdem Kamdem L, Cheng C, Williams RT, Jeha S, Pui CH, Evans WE, Relling MV. Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia. PLoS One. 2015; 10(8):e0135134. PMID: 26252865.
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    77. Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood. 2015 Jul 02; 126(1):69-75. PMID: 25987655.
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    78. Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet. 2015 Jun; 47(6):607-14. PMID: 25938942.
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    79. Fernandez CA, Smith C, Karol SE, Ramsey LB, Liu C, Pui CH, Jeha S, Evans WE, Finkelman FD, Relling MV. Effect of premedications in a murine model of asparaginase hypersensitivity. J Pharmacol Exp Ther. 2015 Mar; 352(3):541-51. PMID: 25573198.
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    80. Dering C, K?nig IR, Ramsey LB, Relling MV, Yang W, Ziegler A. A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required. Front Genet. 2014; 5:323. PMID: 25309579.
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    81. Bhojwani D, Darbandi R, Pei D, Ramsey LB, Chemaitilly W, Sandlund JT, Cheng C, Pui CH, Relling MV, Jeha S, Metzger ML. Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia. Eur J Cancer. 2014 Oct; 50(15):2685-94. PMID: 25087182.
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    82. Fernandez CA, Smith C, Yang W, Dat? M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies. Blood. 2014 Aug 21; 124(8):1266-76. PMID: 24970932.
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    83. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin Pharmacol Ther. 2014 Oct; 96(4):423-8. PMID: 24918167.
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    84. Ramsey LB, Janke LJ, Edick MJ, Cheng C, Williams RT, Sherr CJ, Evans WE, Relling MV. Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model. Pharmacogenet Genomics. 2014 May; 24(5):263-71. PMID: 24710003.
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    85. Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors. Cell Rep. 2013 Nov 27; 5(4):1047-59. PMID: 24268771.
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    86. Relling MV, Ramsey LB. Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy. Hematology Am Soc Hematol Educ Program. 2013; 2013:126-30. PMID: 24319173.
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    87. Ramsey LB, Panetta JC, Smith C, Yang W, Fan Y, Winick NJ, Martin PL, Cheng C, Devidas M, Pui CH, Evans WE, Hunger SP, Loh M, Relling MV. Genome-wide study of methotrexate clearance replicates SLCO1B1. Blood. 2013 Feb 07; 121(6):898-904. PMID: 23233662.
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    88. Kawedia JD, Janke L, Funk AJ, Ramsey LB, Liu C, Jenkins D, Boyd KL, Relling MV. Substrain-specific differences in survival and osteonecrosis incidence in a mouse model. Comp Med. 2012 Dec; 62(6):466-71. PMID: 23561879.
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    89. Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, Kornegay N, Hicks JK, Stewart CF, Kawedia JD, Ramsey LB, Liu C, Evans WE, Relling MV, Broeckel U. Concordance of DMET plus genotyping results with those of orthogonal genotyping methods. Clin Pharmacol Ther. 2012 Sep; 92(3):360-5. PMID: 22871999.
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    90. Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE. PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Hum Mol Genet. 2012 Nov 01; 21(21):4793-804. PMID: 22846425.
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    91. Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin Pharmacol Ther. 2012 Jul; 92(1):112-7. PMID: 22617227.
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    92. Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA. IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle. J Immunol. 2012 Jun 15; 188(12):6084-92. PMID: 22581861.
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    93. Ramsey LB, Bruun GH, Yang W, Trevi?o LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan; 22(1):1-8. PMID: 22147369.
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    94. Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med. 2011 Jun 06; 208(6):1135-49. PMID: 21606506.
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    95. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr; 89(4):571-8. PMID: 21368754.
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    96. Ramsey LB, Vegoe AL, Miller AT, Cooke MP, Farrar MA. Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways. Immunol Lett. 2011 Mar 30; 135(1-2):74-7. PMID: 20933008.
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    97. Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA. RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009 Jun; 10(6):655-64. PMID: 19448632.
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    98. Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunol. 2008 Apr 01; 180(7):4728-41. PMID: 18354197.
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    99. Younossi ZM, Nader FH, Bai C, Sjogren R, Ong JP, Collantes R, Sjogren M, Farmer D, Ramsey L, Terra K, Gujral H, Gurung C, Srishord M, Fang Y. A phase II dose finding study of darbepoetin alpha and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. J Viral Hepat. 2008 May; 15(5):370-8. PMID: 18194172.
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    100. Fass R, Garewal HS, Hayden CW, Ramsey L, Sampliner RE. Preferential repair by squamous epithelium of thermal induced injury to the proximal stomach in patients undergoing ablation of Barrett's esophagus. Gastrointest Endosc. 2001 Jun; 53(7):711-6. PMID: 11375576.
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    101. Kreider RB, Klesges R, Harmon K, Grindstaff P, Ramsey L, Bullen D, Wood L, Li Y, Almada A. Effects of ingesting supplements designed to promote lean tissue accretion on body composition during resistance training. Int J Sport Nutr. 1996 Sep; 6(3):234-46. PMID: 8876343.
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    102. Ramsey L, Williams H, Tolchin S. Clinical procedures review: another casualty of a litigious society. Surg Neurol. 1992 Sep; 38(3):173-8. PMID: 1440201.
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