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Last Name
Institution

Kaela M Varberg, PhD

TitleIndependent Investigator
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City Missouri 64108
ORCID ORCID Icon0000-0001-9672-4158 Additional info
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPathology


    Collapse Biography 
    Collapse education and training
    University of Kansas Medical Center, Kansas City, KSPostdoctoral Fellow2022Placental Biology
    Indiana University School of Medicine, Indianapolis, INPhD2017Cellular and Integrative Physiology
    Rockhurst University, Kansas City, MOB.S.2012 Biochemistry
    Collapse awards and honors
    2023Faber Young Alumni Award, Rockhurst University
    2023Paper of the Year, Basic Science, Perinatal Research Society
    2022Best New Investigator Presentation, Society for Reproductive Investigation
    2021Society Scientific Recognition Award, US DOHaD Society

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Kaela Varberg is an Independent Investigator in the Department of Pediatrics, Division of Neonatology in the Children’s Mercy Research Institute. The Varberg laboratory incorporates next-generation sequencing approaches to identify genetic and environmental (epigenetic) factors impacting placental development and function in the setting of pregnancy complications and disease. Dr. Varberg has collaborated with physician scientists around the country to expand the diversity of human trophoblast stem cell models from clinically available tissue sources, including from chorionic villus biopsies and products of conception from recurrent pregnancy loss. These models are used to study early events of placental development in the context of known pregnancy outcomes. Dr. Varberg also has a keen interest in the developmental origins of health and disease and how abnormal placentation-based pregnancy complications impact fetal development. Her training and experience in placental biology and primary human cell culture has uniquely positioned her to lead the Varberg lab research program that explores how placenta function and pathology contribute to pregnancy success and the developmental origins of disease.
    Collapse research activities and funding
         (VARBERG, KAELA MARGARET)Jun 1, 2018 - Dec 1, 2018
    Lalor Foundation
    Regulation of endovascular trophoblast cell development and uterine spiral artery remodeling
    Role: Principal Investigator

    F32HD096809     (VARBERG, KAELA MARGARET)Dec 1, 2018 - Nov 30, 2021
    NIH
    Regulation of endovascular trophoblast cell development and uterine spiral artery remodeling
    Role: Principal Investigator

    K99HD107262     (VARBERG, KAELA MARGARET)Aug 2, 2022 - Aug 31, 2023
    NIH
    Regulation of invasive trophoblast cell lineage development
    Role Description: The goal of this study is to investigate actions of ASCL2 on the epigenomic landscape of the EVT cell lineage and to evaluate ASCL2 regulation of trophoblast development and invasion in vivo.
    Role: Principal Investigator

    R00HD107262     (VARBERG, KAELA MARGARET)Sep 1, 2023 - Aug 31, 2026
    NIH
    Regulation of invasive trophoblast cell lineage development
    Role Description: The goal of this study is to investigate actions of ASCL2 on the epigenomic landscape of the EVT cell lineage and to evaluate ASCL2 regulation of trophoblast development and invasion in vivo.
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Varberg KM, Dominguez EM, Koseva B, Varberg JM, McNally RP, Moreno-Irusta A, Wesley ER, Iqbal K, Cheung WA, Schwendinger-Schreck C, Smail C, Okae H, Arima T, Lydic M, Holoch K, Marsh C, Soares MJ, Grundberg E. Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Nat Commun. 2023 08 10; 14(1):4826. PMID: 37563143.
      View in: PubMed
    2. Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ. CITED2 is a conserved regulator of the uterine-placental interface. Proc Natl Acad Sci U S A. 2023 01 17; 120(3):e2213622120. PMID: 36626551.
      View in: PubMed
    3. Muto M, Chakraborty D, Varberg KM, Moreno-Irusta A, Iqbal K, Scott RL, McNally RP, Choudhury RH, Aplin JD, Okae H, Arima T, Matsumoto S, Ema M, Mast AE, Grundberg E, Soares MJ. Intersection of regulatory pathways controlling hemostasis and hemochorial placentation. Proc Natl Acad Sci U S A. 2021 12 14; 118(50). PMID: 34876522.
      View in: PubMed
    4. Varberg KM, Soares MJ. Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling. Placenta. 2021 09 15; 113:48-56. PMID: 33985793.
      View in: PubMed
    5. Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ. ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649217.
      View in: PubMed
    6. Nteeba J, Varberg KM, Scott RL, Simon ME, Iqbal K, Soares MJ. Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity. BMJ Open Diabetes Res Care. 2020 06; 8(1). PMID: 32595139.
      View in: PubMed
    7. Soares MJ, Varberg KM, Iqbal K. Hemochorial placentation: development, function, and adaptations. Biol Reprod. 2018 07 01; 99(1):196-211. PMID: 29481584.
      View in: PubMed
    8. Varberg KM, Garretson RO, Blue EK, Chu C, Gohn CR, Tu W, Haneline LS. Transgelin induces dysfunction of fetal endothelial colony-forming cells from gestational diabetic pregnancies. Am J Physiol Cell Physiol. 2018 10 01; 315(4):C502-C515. PMID: 29949406.
      View in: PubMed
    9. Varberg KM, Winfree S, Dunn KW, Haneline LS. Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro. J Vis Exp. 2018 01 31; (131). PMID: 29443032.
      View in: PubMed
    10. Gohn CR, Blue EK, Sheehan BM, Varberg KM, Haneline LS. Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus. J Cell Physiol. 2017 Jul; 232(7):1885-1892. PMID: 27966787.
      View in: PubMed
    11. Varberg KM, Winfree S, Chu C, Tu W, Blue EK, Gohn CR, Dunn KW, Haneline LS. Kinetic analyses of vasculogenesis inform mechanistic studies. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C446-C458. PMID: 28100488.
      View in: PubMed
    12. Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, Gohn CR, Varberg KM, McClintick JN, Haneline LS. Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus. Diabetes. 2015 Jul; 64(7):2664-75. PMID: 25720387.
      View in: PubMed
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