Alain C. Cuna, MD
Title | Physician, Neonatologist |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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ORCID
| 0000-0002-8174-4487 |
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vCard | Download vCard |
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Title | Associate Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Title | Clinical Assistant Professor of Pediatrics |
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Institution | University of Kansas Medical Center |
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Department | Pediatrics |
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Biography University of Alabama at Birmingham, Birmingham, AL | Fellowship | 2014 | Neonatal-Perinatal Medicine | Winthrop University Hospital, Mineola, NY | Residency | 2011 | Pediatrics | Philippine General Hospital, Manila, Philippines | Internship | 2006 | Doctor of Medicine | University of the Philippines, Manila, Philippines | MD | 2006 | Doctor of Medicine |
Overview Research Dr. Cuna's main research interest is on defining the pathogenesis of necrotizing enterocolitis (NEC) – a devastating inflammatory bowel disease of preterm infants - and translating this knowledge to improve outcomes of NEC. His current focus is on understanding how host genetics and intestinal bacterial communities interact with each other to modulate inflammation in the developing neonatal gut. New knowledge gained from this research is anticipated to help in the development of personalized, microbial-based therapies based on underlying genetic predisposition and/or gut microbiome signatures to help maintain gut homeostasis. Such novel, individualized therapies are expected to drastically reduce the incidence of NEC in a safe and effective manner by targeting infants at highest risk of the disease.
K08DK125735 (CUNA, ALAIN)Aug 1, 2020 - Jul 31, 2025 NIH Gene-environment interactions in necrotizing enterocolitis: impact of SIGIRR mutation and gut microbiota on intestinal TLR hyperactivity Role: Principal Investigator |
| (CUNA, ALAIN and CHAN, SHERWIN)Sep 19, 2022 - Sep 18, 2022 American College of Radiology Multicenter Comparative Effectiveness Trial of Bowel Ultrasound for Diagnosis of Necrotizing Enterocolitis (NEC) Role: Co-Principal Investigator |
Bibliography
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Cuna A, Premkumar MH, Sampath V. Artificial intelligence to classify acquired intestinal injury in preterm neonates-a new perspective. Pediatr Res. 2024 Jul; 96(1):30-32. PMID: 38499626.
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Cuna A, Rathore D, Bourret K, Opfer E, Chan S. Degree of Uncertainty in Reporting Imaging Findings for Necrotizing Enterocolitis: A Secondary Analysis from a Pilot Randomized Diagnostic Trial. Healthcare (Basel). 2024 Feb 21; 12(5). PMID: 38470621.
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Hanna M, Ahmad I, Yanowitz T, Kim J, Hunter C, DiGeronimo R, Ahmad KA, Sullivan K, Markel TA, Hair AB, Chaaban H, Pammi M, Huff KA, Jasani B, Fuchs L, Cuna A, Garg PM, Reber K, Premkumar MH. Current Patterns of Probiotic Use in U.S. Neonatal Intensive Care Units: A Multi-Institution Survey. Am J Perinatol. 2024 05; 41(S 01):e2658-e2665. PMID: 37494969.
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Cuna A, Nsumu M, Menden HL, Chavez-Bueno S, Sampath V. The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated with Lactobacillus rhamnosus GG. Microorganisms. 2023 Jun 01; 11(6). PMID: 37374984.
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Sampath V, Martinez M, Caplan M, Underwood MA, Cuna A. Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies. Mucosal Immunol. 2023 04; 16(2):208-220. PMID: 36804483.
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Cuna A, Morowitz MJ, Sampath V. Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review. Front Pediatr. 2023; 11:1112812. PMID: 36865691.
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Rao K, Cuna A, Chavez-Bueno S, Menden H, Yu W, Ahmed I, Srinivasan P, Umar S, Sampath V. Effect of Various Preterm Infant Milk Formulas on NEC-Like Gut Injury in Mice. Front Pediatr. 2022; 10:902798. PMID: 35874567.
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Cuna A, Chan S, Jones J, Sien M, Robinson A, Rao K, Opfer E. Feasibility and acceptability of a diagnostic randomized clinical trial of bowel ultrasound in infants with suspected necrotizing enterocolitis. Eur J Pediatr. 2022 Aug; 181(8):3211-3215. PMID: 35713688.
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Mikhael M, Cleary JP, Zaniletti I, Truog WE, Ibrahim J, DiGeronimo R, Cuna A, Kielt MJ, Coghill CH, Vyas-Read S, Yallapragada S, Engle WA, Savani RC, Murthy K, Lagatta JM. Chronic lung disease in full-term infants: Characteristics and neonatal intensive care outcomes in infants referred to children's hospitals. Pediatr Pulmonol. 2022 09; 57(9):2082-2091. PMID: 35578392.
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Feldman K, Nitkin CR, Cuna A, Oschman A, Truog WE, Norberg M, Nyp M, Taylor JB, Lewis T. Corticosteroid response predicts bronchopulmonary dysplasia status at 36 weeks in preterm infants treated with dexamethasone: A pilot study. Pediatr Pulmonol. 2022 07; 57(7):1760-1769. PMID: 35434928.
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Mishra V, Cuna A, Singh R, Schwartz DM, Chan S, Maheshwari A. Imaging for Diagnosis and Assessment of Necrotizing Enterocolitis. Newborn (Clarksville). 2022 Jan-Mar; 1(1):182-189. PMID: 36864828.
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Cuna A, Lagatta JM, Savani RC, Vyas-Read S, Engle WA, Rose RS, DiGeronimo R, Logan JW, Mikhael M, Natarajan G, Truog WE, Kielt M, Murthy K, Zaniletti I, Lewis TR. Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants. Pediatr Pulmonol. 2021 10; 56(10):3283-3292. PMID: 34379886.
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Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2022 01; 42(1):58-64. PMID: 34354227.
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Cuna A, Quiqley A, Varghese K, Ciccolari-Micaldi G, Oliveros C, Cheng AL, Norberg M, Truog WE. Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia. J Perinatol. 2021 08; 41(8):1956-1962. PMID: 34103670.
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Cuna A, Sampath V, Khashu M. Racial Disparities in Necrotizing Enterocolitis. Front Pediatr. 2021; 9:633088. PMID: 33681105.
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Cuna A, Morowitz MJ, Ahmed I, Umar S, Sampath V. Dynamics of the preterm gut microbiome in health and disease. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G411-G419. PMID: 33439103.
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Hansen TP, Oschman A, K Pallotto E, Palmer R, Younger D, Cuna A. Using quality improvement to implement consensus guidelines for postnatal steroid treatment of preterm infants with developing bronchopulmonary dysplasia. J Perinatol. 2021 04; 41(4):891-897. PMID: 33093625.
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Alexander KM, Chan SS, Opfer E, Cuna A, Fraser JD, Sharif S, Khashu M. Implementation of bowel ultrasound practice for the diagnosis and management of necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed. 2021 Jan; 106(1):96-103. PMID: 32398270.
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Cuna A, Yu W, Menden HL, Feng L, Srinivasan P, Chavez-Bueno S, Ahmed I, Umar S, Sampath V. NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice. Pediatr Res. 2020 10; 88(4):546-555. PMID: 32053825.
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Cammack B, Noel-MacDonnell J, Cuna A, Manimtim W. Impact of tracheostomy on language and cognitive development in infants with severe bronchopulmonary dysplasia. J Perinatol. 2020 02; 40(2):299-305. PMID: 31659237.
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Linafelter A, Cuna A, Liu C, Quigley A, Truog WE, Sampath V, Oschman A. Extended course of prednisolone in infants with severe bronchopulmonary dysplasia. Early Hum Dev. 2019 09; 136:1-6. PMID: 31265946.
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Cuna A, Lewis T, Dai H, Nyp M, Truog WE. Timing of postnatal corticosteroid treatment for bronchopulmonary dysplasia and its effect on outcomes. Pediatr Pulmonol. 2019 02; 54(2):165-170. PMID: 30537393.
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Cuna AC, Lee JC, Robinson AL, Allen NH, Foley JE, Chan SS. Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis. Ultrasound Q. 2018 Sep; 34(3):113-118. PMID: 29369246.
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Cuna A, George L, Sampath V. Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions. Semin Fetal Neonatal Med. 2018 12; 23(6):387-393. PMID: 30292709.
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Cuna A, Liu C, Govindarajan S, Queen M, Dai H, Truog WE. Usefulness of an Online Risk Estimator for Bronchopulmonary Dysplasia in Predicting Corticosteroid Treatment in Infants Born Preterm. J Pediatr. 2018 06; 197:23-28.e2. PMID: 29551313.
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Cuna AC, Reddy N, Robinson AL, Chan SS. Bowel ultrasound for predicting surgical management of necrotizing enterocolitis: a systematic review and meta-analysis. Pediatr Radiol. 2018 05; 48(5):658-666. PMID: 29260286.
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Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X, Sampath V. Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. Pediatr Res. 2018 01; 83(1-1):164-174. PMID: 28846670.
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Akangire G, Cuna A, Lachica C, Fischer R, Raman S, Sampath V. Neonatal Graves' Disease with Maternal Hypothyroidism. AJP Rep. 2017 Jul; 7(3):e181-e184. PMID: 28948062.
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Cuna A, Winter L. Quality Improvement Project to Reduce Delayed Vaccinations in Preterm Infants. Adv Neonatal Care. 2017 Aug; 17(4):245-249. PMID: 28375854.
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Cuna A, Lewis T, Oschman A, Dai HY, Brophy K, Norberg M, Nyp M, Truog W. Outcomes of Infants Who Failed to Extubate despite Systemic Corticosteroids. Am J Perinatol. 2017 12; 34(14):1458-1463. PMID: 28704843.
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Cuna A, Govindarajan S, Oschman A, Dai H, Brophy K, Norberg M, Truog W. A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants. J Perinatol. 2017 03; 37(3):301-305. PMID: 27906194.
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Cuna A, Sampath V. Genetic alterations in necrotizing enterocolitis. Semin Perinatol. 2017 02; 41(1):61-69. PMID: 27836427.
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Olave N, Lal CV, Halloran B, Pandit K, Cuna AC, Faye-Petersen OM, Kelly DR, Nicola T, Benos PV, Kaminski N, Ambalavanan N. Regulation of alveolar septation by microRNA-489. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 01; 310(5):L476-87. PMID: 26719145.
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Cuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman DK, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani TJ, Ambalavanan N. Alterations in gene expression and DNA methylation during murine and human lung alveolar septation. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):60-73. PMID: 25387348.
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Salas AA, Cuna A, Bhat R, McGwin G, Carlo WA, Ambalavanan N. A randomised trial of re-feeding gastric residuals in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2015 May; 100(3):F224-8. PMID: 25552280.
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Ambalavanan N, Cotten CM, Page GP, Carlo WA, Murray JC, Bhattacharya S, Mariani TJ, Cuna AC, Faye-Petersen OM, Kelly D, Higgins RD. Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr. 2015 Mar; 166(3):531-7.e13. PMID: 25449221.
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Cuna A, Hakima L, Tseng YA, Fornier B, Islam S, Quintos-Alagheband ML, Khullar P, Weinberger B, Hanna N. Clinical dilemma of positive histologic chorioamnionitis in term newborn. Front Pediatr. 2014; 2:27. PMID: 24772410.
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Cuna A, Kandasamy J, Sims B. B-type natriuretic peptide and mortality in extremely low birth weight infants with pulmonary hypertension: a retrospective cohort analysis. BMC Pediatr. 2014 Mar 11; 14:68. PMID: 24612708.
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Year | Publications |
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2014 | 4 | 2015 | 2 | 2016 | 2 | 2017 | 5 | 2018 | 4 | 2019 | 2 | 2020 | 3 | 2021 | 5 | 2022 | 5 | 2023 | 4 | 2024 | 2 |
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